Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.

Abstract: The present invention is related to a kit for cancer diagnosis or prognosis analysis. MEST in the present invention is a biomarker for cancer having significantly improved accuracy and reliability, especially, breast cancer and liver cancer as well as metastatic cancer. In addition, the present invention could be used for cancer diagnosis and prognosis in a biological sample (for example, blood or serum) by using MEST only specifically expressed from cells and tissues of cancer patients.

Abstract: The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-?B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.

Abstract: Apparatus and method of transmitting a preamble having additional information in differential modulation packet data communication. The apparatus includes a phase rotator that outputs a phase rotation quantity corresponding to additional information to be applied to a transmission target packet, a transmission-multiplier that multiplies the phase rotation quantity output from the phase rotator by a preamble to be transmitted, a symbol mapper that converts header and payload data to be applied to the transmission target packet into symbols and outputs the same, a multiplexer that processes an output signal of the transmission-multiplier and an output signal of the symbol mapper to be selectively output through an output end to form a symbol stream in units of packets, and a differential symbol converter that converts the symbol stream output from the multiplexer according to a predetermined differential modulation method and outputs the converted symbol stream.

Abstract: The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived from Leucosporidium sp., which is the polar yeast, for synthesizing a recombinant polynucleotide by optimizing and altering a gene, which codes the antifreeze protein derived from the polar yeast, for a yeast expression system, and for expressing same using the yeast expression system.

Abstract: A slide-type core retainer for a sample collector including a sampler tube driven into a sea floor. The slide-type core retainer includes a catcher holder detachably coupled to a tip end of the sampler tube; a catcher installed on an inner peripheral surface of a tip end of the catcher holder and configured to allow sediment introduction into the sampler tube and preventing sediment from being lost using resiliency. A control member slidably installed inside the catcher holder controls opening and closing of the catcher. The control member is coupled to the catcher before sample collection so that the catcher remains opened. The control member slides into an inner side of the catcher holder while being separated from the catcher by the resistance of the solid sediment such that the catcher is closed, when resistance is generated by solid sediment after the sampler tube is driven into the sediment.

Abstract: Disclosed herein is an oscillating vane type pump actuator. The pump actuator of the present invention provides a method of preventing fretting corrosion from being caused on joined surfaces of elements. A cylinder (3c) has a comparatively low radial strength, and each of side covers (1c) and (2c) has a high radial strength. A cylindrical portion (1c-c), (2c-c) is provided on each side cover. Thus, when high pressure of work oil distorts the cylinder into a shape in which the cross-section of the cylinder becomes an ellipse-like shape, the cylindrical portions of the side covers act such that they are distorted in the same shape as that of the cylinder. Further, a passage that always communicates with a low-pressure side working chamber is formed in the contact surfaces between a fixed vane that is fixed to the cylinder and the side covers.

Abstract: The present invention relates to marine medaka genes responding to the exposure of endocrine-disrupting chemicals, and a method for diagnosing an aquatic eco-system contamination using the marine medaka genes. Specifically, the method for diagnosing an aquatic eco-system contamination, according to the present invention, makes use of marine medaka genes of which the expression amount changes according to 17?-estradiol, or marine medaka genes of which the expression amount changes according to bisphenol A. Since it was verified that genes of marine medaka exposed to 17?-estradiol are changed or genes of marine medaka exposed to bisphenol A are changed, the present invention can be used in a useful manner for a microarray chip in which marine medaka genes responding to 17?-estradiol or marine medaka genes responding to bisphenol A are integrated, for a diagnosis using same, and for a method for diagnosing health or detecting stress of a marine eco-system by applying a kit having the microarray chip.

Abstract: The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.

Abstract: The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-?B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Abstract: The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, RAMALIN™, having excellent antioxidant activity, isolated from the Antarctic lichen Ramalina terebrata, a method for preparing the RAMALIN™, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN™ as an active ingredient. The RAMALIN™ according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

Abstract: Disclosed is an assembled helical turbine system, which can prevent its assembly/disassembly from being hindered by a rotational force generated during the assembly/disassembly process. The assembled helical turbine system includes a helical turbine formed with a plurality of blades in such a manner as to continuously generate a rotational force under unidirectional or multidirectional fluid flow; a housing assembly for rotatably supporting the helical turbine while surrounding the helical turbine; stoppers formed on a peripheral surface of the housing assembly in such a manner as to protrude to a predetermined height from the peripheral surface; and a housing supporter for supporting the housing assembly in such a manner that the housing assembly can be inserted into and withdrawn from the housing supporter, the housing supporter having catch grooves that are recessed in a shape corresponding to the stoppers so as to fix the stoppers.

Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.

Abstract: Disclosed is an assembled helical turbine system, which can strengthen weakenings of a housing assembly, and simultaneously can be easily assembled/disassembled. The assembled helical turbine system comprises the housing assembly including a plurality of bearing spiders for rotatably supporting a rotating shaft of a helical turbine, and a plurality of side posts for connecting and fixing the respective bearing spiders to each other, the side posts being fixed in such a manner as to radially protrude by a predetermined length from peripheral surfaces of the bearing spiders; filling members for filling and reinforcing spaces between the peripheral surfaces of the bearing spiders and outlines of protruding portions of the side posts; and a housing supporter for supporting the housing assembly in such a manner that the housing assembly can be inserted into and withdrawn from the housing supporter, the housing supporter having catch grooves that are recessed in a shape corresponding to stoppers.

Abstract: Disclosed is a complex sampling apparatus. The complex sampling apparatus includes a main sampling unit having a predetermined weight to be sunk to sea floor and inserted into the sea floor in order to collect a sample including a sediment; one or a plurality of sub-sampling unit disposed at a side of the main sampling unit to detect that the sub-sampling unit arrives on the sea floor and to scrape a predetermined amount of the sample from a surface of the sea floor; and an image acquiring unit installed to the main sampling unit to acquire an image of the sea floor.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.