Patents Assigned to Kupat Holim Health Insurance Institution of the General Federation of Labor
  • Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
    Patent number: 5710176
    Abstract: This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: January 20, 1998
    Assignees: Bar-Ilan University, Kupat Holim Health Insurance Institution of the General Federation of Labor
    Inventors: Ada Rephaeli, Abraham Nudelman
  • Biologically active carboxylic acid esters
    Patent number: 5200553
    Abstract: Biologically active carboxylic acid esters which promote antitumor or immune response are selected from the group consisting of compounds having formulas (I), (II) and (III):XCH.sub.2 --CHX--CHX--C(.dbd.O)--O--Z (I)CH.sub.3 --CO--CH.sub.2 --C(.dbd.O)--O--Z (II)CH.sub.3 --CH.sub.2 --CO--C(.dbd.O)--O--Z (III)wherein X is H, or one X only may be OH; Z is --CHR--O--(O.dbd.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: April 6, 1993
    Assignee: Kupat Holim Health Insurance Institution of the General Federation of Labor
    Inventors: Abraham Nudelman, Matitiahu Shaklai, Ada Rephaeli