Patents Assigned to Kyowa Hakko Kogyo Co., Ltd.
-
Publication number: 20090232917Abstract: There has been a demand in the marketplace for medicines, functional foods and so on which can relieve subjective symptoms of fatigue in persons having these subjective symptoms, and enabling the persons to have productive days. That is, an object of the present invention is to provide a composition for relieving subjective symptoms of fatigue. According to the present invention, a safe and effective composition for relieving subjective symptoms of fatigue which contains ornithine or a salt thereof as an active ingredient can be provided.Type: ApplicationFiled: October 4, 2006Publication date: September 17, 2009Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Miho Komatsu, Koji Morishita, Akemi Ogawa, Goro Hori, Miho Takada
-
Publication number: 20090227012Abstract: A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.Type: ApplicationFiled: February 27, 2009Publication date: September 10, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Kenya SHITARA, Kazuyasu Nakamura, Emi Hosaka, Akiko Tanaka, Masamichi Koike
-
Publication number: 20090197303Abstract: The present invention provides: a protein having dipeptide-synthesizing activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity using the transformant or the like; a process for producing a dipeptide using the protein having dipeptide-synthesizing activity; and a process for producing a dipeptide using, as an enzyme source, a culture of a transformant or a microorganism which produces the protein having dipeptide-synthesizing activity or the like.Type: ApplicationFiled: December 27, 2006Publication date: August 6, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Kuniki Kino, Atsushi Noguchi, Yuji Nakazawa, Makoto Yagasaki
-
Publication number: 20090191589Abstract: The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.Type: ApplicationFiled: March 18, 2009Publication date: July 30, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata, Aya Kubota, Hajime Ikeda
-
Publication number: 20090181948Abstract: The present invention provides a diamine derivative or the like represented by the general formula (I): {wherein Q represents an oxygen atom or the like, RG represents a hydrogen atom or the like, RI represents (wherein p and r may be the same or different, and each represents 0 or the like, RA represents a hydrogen atom or the like, and RB and RC may be the same or different, and each represents a hydrogen atom or the like), RH represents a hydrogen atom or the like, and RJ represents: (wherein q and s may be the same or different, and each represents 0 or the like, RD represents a hydrogen atom or the like, and RE and RF may be the same or different, and each represents a hydrogen atom or the like) or the like}, etc.Type: ApplicationFiled: January 31, 2006Publication date: July 16, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Setsuya Sasho, Takashi Seishi, Eri Atsumi, Mariko Osakada, Ryo Hirose, Shinichiro Toki, Katsuyoshi Tsukii, Shiro Shirakura
-
Patent number: 7560461Abstract: The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.Type: GrantFiled: August 22, 2005Date of Patent: July 14, 2009Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Anjali Pandey, Robert M. Scarborough, Kenji Matsuno, Michio Ichimura, Yuji Nomoto, Shinichi Ide, Eiji Tsukuda, Junko Sasaki, Shoji Oda
-
Publication number: 20090176760Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.Type: ApplicationFiled: February 7, 2008Publication date: July 9, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
-
Publication number: 20090148916Abstract: The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.Type: ApplicationFiled: November 17, 2008Publication date: June 11, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Hirofumi Endo, Yoshiyuki Yonetani, Hiroshi Mizoguchi, Shin-ichi Hashimoto, Akio Ozaki
-
Patent number: 7541365Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: GrantFiled: November 10, 2006Date of Patent: June 2, 2009Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
-
Publication number: 20090137583Abstract: The present invention provides 2-aminoquinazoline derivatives represented by formula (I): wherein R1 and R2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X represents a bond or CR7aR7b wherein R7a and R7b may be the same or different and each represents a hydrogen atom, and the like; when X is a bond, R3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; when X is CR7aR7b wherein R7a and R7b have the same meanings as defined above, respectively, R3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like; R4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and R5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 28, 2006Publication date: May 28, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Kuniyuki Kishikawa, Hidetomo Imase, Hajime Kashima, Kiyotoshi Mori, Toshihide Ikemura, Yoshisuke Nakasato, Misato Tomuro
-
Patent number: 7538241Abstract: (wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.Type: GrantFiled: December 24, 2004Date of Patent: May 26, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yushi Kitamura, Shinji Nara, Hiroshi Nakagawa, Rieko Nakatsu, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Yukimasa Shiotsu, Yutaka Kanda
-
Patent number: 7538224Abstract: The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.Type: GrantFiled: June 10, 2004Date of Patent: May 26, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shinji Nara, Hiroshi Nakagawa, Yutaka Kanda, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Jun-ichi Saito, Yukimasa Shiotsu, Shiro Akinaga
-
Publication number: 20090130708Abstract: The present invention provides: (1) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a constituent or a polypeptide consisting of three or more amino acids; and (2) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a constituent, a polypeptide consisting of three or more amino acids, or an amino acid amide; and a process for producing the dipeptide crystals.Type: ApplicationFiled: March 29, 2006Publication date: May 21, 2009Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata, Shizuo Tsuchiya, Tetsuo Nishimura
-
Publication number: 20090123980Abstract: The present invention provides a polypeptide which has: (i) an amino acid sequence wherein one or more amino acid residues are substituted in the region at positions 20 to 38 from the N terminus of the amino acid sequence shown in SEQ ID NO: 1; or (ii) an amino acid sequence wherein one or more amino acid residues are substituted in the region at positions 20 to 38 from the N terminus of the amino acid sequence shown in SEQ ID NO: 1 and one or more amino acid residues are deleted, substituted or added in the region at positions 1 to 19 or 39 to 294; and which has N-acetylglutamate kinase activity.Type: ApplicationFiled: September 28, 2005Publication date: May 14, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Masato Ikeda, Tetsuo Nakano, Satoshi Mitsuhashi, Mikiro Hayashi, Kenji Tanaka
-
Patent number: 7531333Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.Type: GrantFiled: August 13, 2007Date of Patent: May 12, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Koichiro Miyake, Shinichi Hashimoto, Hiroaki Motoyama, Akio Ozaki, Haruo Seto, Tomohisa Kuzuyama, Shunji Takahashi
-
Patent number: 7524852Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.Type: GrantFiled: June 6, 2003Date of Patent: April 28, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Tsutomu Matsumura, Hiroshi Ishida, Yosuke Yamaura, Seiji Aratake, Etsuo Ohshima, Koji Yanagawa, Motoki Miyama, Koji Suzuki, Ari Kawabe, Satoshi Nakanishi, Katsuya Kobayashi, Takashi Sato, Ichiro Miki, Kimihisa Ueno, Shinya Fujii, Miho Iwase
-
Publication number: 20090105277Abstract: For example, an agent for preventing and/or treating movement disorder comprising, as an active ingredient, a triazolopyrimidine derivative having an adenosine A2A receptor antagonistic action, which is represented by the following formula (I): (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, R2 represents a hydrogen atom, or the like, R3 represents —WR4, or the like, and Q1 represents a hydrogen atom or 3,4-dimethoxybenzyl), or a pharmaceutically acceptable salt thereof, and the like are provided.Type: ApplicationFiled: June 7, 2006Publication date: April 23, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Takako Kadowaki, Minoru Kobayashi, Shizuo Shiozaki, Naoki Seno
-
Patent number: 7521079Abstract: The present invention relates to a method for producing a liquid plant extract containing plant powder, which includes concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the active ingredient; a process for producing a plant extract containing plant powder, which is characterized by concentrating and drying a liquid extract containing an active ingredient in the presence of the plant powder.Type: GrantFiled: June 21, 2002Date of Patent: April 21, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yasushi Sakai, Yoshiharu Yokoo
-
Patent number: 7517673Abstract: The present invention can provide a process for producing a protein having ?1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having ?1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella and a process for producing a galactose-containing complex carbohydrate using a transformant capable of producing a protein having ?1.4-galactosyltransferase activity derived from a microorganism.Type: GrantFiled: April 13, 2007Date of Patent: April 14, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuo Endo, Satoshi Koizumi
-
Publication number: 20090094710Abstract: A mouse or progenies thereof in which genome is modified so as to have decreased or deleted activity of an enzyme relating to modification of a sugar chain in which the 1-position of fucose is bound to the 6-position of N-acetylglucosamine in the reducing end through ?-bond in a complex N-glycoside-linked complex sugar chain.Type: ApplicationFiled: October 30, 2008Publication date: April 9, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventor: Naoyuki Taniguchi