Abstract: This invention relates to a stable injection paclitaxel formulation having polyoxyethylene sorbitol oleic polyester as a main solubilizer, and appears to have less toxicity and greater stability compared to polyethoxylated castor oil-containing formulation which is clinically used all over the world. The formulation includes paclitaxel 30 mg, povidone 80 mg, oxyethylene sorbitol oleate 0.5 to 2.0 ml, (oxyethylene glycol).sub.15-20 fatty acid monoester 0.5 to 2.0 ml, polyethylene glycol 1.0 ml, and anhydrous alcohol 2.0 ml. The oxyethylene sorbitol oleate is either (oxyethylene).sub.60 sorbitol tetraoleate or (oxyehtylene).sub.45 sorbitol trioleate.