Abstract: A liquid chromatography micro-autosampler is disclosed that permits the sampling of very small samples quantities at high accuracy, while minimizing extracolumn band broadening. The autosampler employ a sample intake tubing connected to the injection valve, that is further connected to an aspirating device. The intake tubing terminates within the hollow bore of a needle which is used to penetrate sample containers. Improved injection profiles are obtained by minimizing injection plug dispersion with back flushing of the injection plug and a low dispersion injection routine and extremely small sample quantities can be handled with a micro pick-up injection routine.
Type:
Grant
Filed:
October 11, 1996
Date of Patent:
September 29, 1998
Assignee:
L C Packings, Nederland B.V.
Inventors:
Johannes Petrus Cornelis Vissers, Jean-Pierre Chervet, Pierre Salzmann