Abstract: Disclosed herein is a transgenic non-human animal carrying a transgene which expresses non-infectious HIV ribonucleic acid and complementary proteins thereof. Among the expressed proteins, which can be found in the milk, serum and several tissues, are the gag and envelope proteins. The transgenic animal is useful as a source for obtaining the complementary proteins, and as an animal model to study HIV host cell interactions and to evaluate anti-HIV drugs.
Type:
Grant
Filed:
August 20, 1991
Date of Patent:
July 31, 2001
Assignee:
L'Institut de Recherches Cliniques de Montreal
Abstract: Disclosed herein is a transgenic mouse carrying a transgene which expresses non-infectious HIV ribonucleic acid, and the complementary proteins thereof. The transgenic mouse is useful as a source for obtaining the complementary proteins, and as an animal model to study HIV host cell interactions and to evaluate anti-HIV drugs.
Type:
Grant
Filed:
August 24, 1994
Date of Patent:
November 12, 1996
Assignee:
L'Institut de Recherches Cliniques de Montreal
Abstract: Novel peptides in substantially pure form and selected from the group of peptides having the amino acid sequence:X-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Y-ZwhereinY is selected from the group consisting of -Asn, -Asn-Ser, -Asn-Ser-Phe, -Asn-Ser-Phe-Arg, and -Asn-Ser-Phe-Arg-Tyr;Z is OH or NH.sub.2 ; andX is selected from the group consisting of H, Ser-, Ser-Ser-, Arg-Ser-Ser-, Arg-Arg-Ser-Ser-, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser-, Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, and Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gl y-Arg-Gly-Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu-Arg-Ala-L eu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-,are disclosed as having diuretic, natriuretic, vasorelaxant, hypotensive or anti-hypertensive properties.
Type:
Grant
Filed:
August 27, 1984
Date of Patent:
August 19, 1986
Assignee:
L'Institut de Recherches Cliniques de Montreal
Inventors:
Gaetan Thibault, Raul Garcia, Marc Cantin, Nabil Seidah, Claude Lazure, Michel Chretien