Abstract: The present invention relates to microorganisms that express, or have attached to their surface, a TNF? binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNF? and therefore reducing the content of free TNF? and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.
Type:
Grant
Filed:
January 5, 2011
Date of Patent:
June 17, 2014
Assignees:
University of Ljubljana, Institute Jozef Stefan, Labena d.o.o.
Inventors:
Mojca Lunder, Matjaz Ravnikar, Borut Strukelj, Ales Berlec, Boris Ceh
Abstract: The present invention relates to microorganisms that express, or have attached to their surface, a TNF? binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNF? and therefore reducing the content of free TNF? and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.
Type:
Application
Filed:
January 5, 2011
Publication date:
November 8, 2012
Applicants:
UNIVERSITY OF LJUBLJANA, LABENA D.O.O., INSTITUTE JOZEF STEFAN
Inventors:
Mojca Lunder, Matjaz Ravnikar, Borut Strukelj, Ales Berlec, Boris Ceh