Patents Assigned to Laboratoire Tetra Medical
  • Patent number: 9567406
    Abstract: A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralization, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 14, 2017
    Assignees: LABORATOIRE TETRA MEDICAL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Laurent David, Alexandra Montembault, Mylène Desorme
  • Patent number: 9238880
    Abstract: The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element.
    Type: Grant
    Filed: February 15, 2010
    Date of Patent: January 19, 2016
    Assignees: LABORATOIRE TETRA MEDICAL, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain Domard, Laurent David, Alexandra Montembault, Mylène Desorme
  • Publication number: 20150126957
    Abstract: The absorbent elongated pledget (1) includes two opposite width ends, the pledget being made from a flexible, hydrophilic material, and having a portion that can be detected from outside the body (3). The pledget is characterized in that at least one of the two width ends of same is folded on itself, the fold of the width end being held by a fastening element (2) in a fold forming a cylindrical shape of the pledget and allowing insertion into and removal from a trocar.
    Type: Application
    Filed: April 12, 2013
    Publication date: May 7, 2015
    Applicant: LABORATOIRE TETRA MEDICAL
    Inventors: François Marchal, Denis Artus, Thierry Bouet
  • Publication number: 20130252498
    Abstract: A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralisation, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 26, 2013
    Applicant: Laboratoire Tetra Medical
    Inventors: Laurent David, Alexandra Montembault, Mylène Desorme
  • Publication number: 20120022242
    Abstract: The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element.
    Type: Application
    Filed: February 15, 2010
    Publication date: January 26, 2012
    Applicants: Laboratoire Tetra Medical, Centre National De La Recherche Scientifique, Universite Claude Bernad Lyon I
    Inventors: Alain Domard, Laurent David, Alexandra Montembault, Mylène Desorme