Abstract: The present invention relates to novel hydrocolloid adhesive masses consisting of an adhesive mixture based on a low molecular polyisobutylene and a poly(styrene/olefin/styrene) block polymer, and of a cellulose derivative, with which an acrylate polymer with a glass transition temperature below ?20° C. is associated for the purpose of increasing the resistance to deterioration of the absorption capacity of said hydrocolloid adhesive mass after radiosterilization. The invention further relates to the use of these novel hydrocolloid adhesive masses for medical, dermatological or cosmetic purposes and particularly for the production of dressings for the treatment of blisters, exudative wounds, burns and superficial, deep, chronic or acute dermo-epidermal lesions.

Abstract: The compress is of the type including a contact surface with the wound or burn which has an elastomeric matrix highly plasticized with a non-polar oil or grease, the elastomeric matrix containing a hydrocolloid in dispersion. The elastomeric matrix also contains, in dispersion, at least one antiseptic and at least one surfactant with a hydrophilic/lipophilic balance (HLB) greater than 10. The invention is applicable particularly to compresses and dressings.

Abstract: The invention concerns a device comprising a dressing provided with a layer (8) for absorbing the wound exudates and electric supply means (9) to circulate a current in said wound, through the dressing. The invention is characterized in that said layer (8) consists of a dry hydrophile substantially non-conductive layer at the time it is applied on the wound, the subsequent migration of the exudates into the thickness of said layer (8) controlling the activation of said electric supply means (9), concomitantly with the continuation of the process of exudate absorption by said layer (8).

Abstract: A miniature valve for filling the reservoir of an apparatus for the transdermal administration of a medicine including a) a substrate, b) a fuel charge arranged on the substrate opposite the passage to be opened through it, and c) an electric resistor placed in contact with the fuel charge so that the supply of this resistor with a predetermined electric energy ensures the combustion of the charge and the opening of the passage by local rupture of the substrate under the pressure of the fuel gases of the charge. The device is useful for filling a medicine reservoir for the transdermal administration medicine aided by inophoresis.

Abstract: The invention concerns a novel hydrophile adhesive mass to be used for medical purposes characterised in that said hydrophile adhesive mass comprises:(a) 10 to 35 parts by weight of sequenced poly(styrene/olefin/styrene) copolymer, in particular poly(styrene/isoprene/styrene),(b) 20 to 50 parts by weight of a tackifier resin,(c) 2 to 15 parts by weight of an acrylate polymer with a glass temperature less than -20.degree. C.,(d) 2 to 25 parts by weight of a plasticizer, in particular a plasticizing oil,(e) 20 to 50 parts by weight of a hydrocolloid,(f) 0.1 to 2 parts by weight of at least one antioxidant.The invention also concerns the use of this adhesive mass for making protective bandages, in particular for treating blisters, skin-deep dermo-epidermic lesions, exudative wounds and burns.

Abstract: A novel transdermal system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 20-50 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, (b) 30-60 parts by weight of a tackifyier resin, (c) 4-25 parts by weight of propylene glycol laurate, (d) 2-10 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-- C.sub.15 group, (e) 0.01-2 parts by weight of a stabilizing agent, (f) 0.1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components, and (g) 1-12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone copolymer. A method for preparing said system and the therapeutical use thereof are also disclosed.

Abstract: A novel system for percutaneously delivering at least two active principles, consisting of at least two juxtaposed devices. The system includes (i) a first device containing a mixture of all the active principles in which at least one first active principle (A) is present in an amount enabling the effective therapeutic dose to be delivered, and at least one second active principle (B) is present in an amount smaller than the amount needed to deliver the effective therapeutic dose; and (ii) one or more additional devices each containing a single active principle (B) selected from those in the first device and provided in an amount smaller than the amount needed to deliver the effective therapeutic dose, said additional device(s) being designed to top up the amount of each of the active principles (B) in the system until the effective therapeutic dose is achieved.

Abstract: A device for the percutaneous administration of a medicament for treating male impotence comprises two reservoirs (1,2) hydratable with a medicament solution and intended to be applied to the skin of the penis. The reservoirs are mounted on substantially cylindrical bracelet-shaped means (8) with an elastically expansible diameter to support and press the reservoirs (1,2) against said skin during the treatment. The device includes a sensor which is fixed on the bracelet and is sensitive to the expansion of the bracelet in order to deliver a signal to the user.

Abstract: A solution of active principle, in ionized form, impregnates a layer (2) forming part of the reservoir (1). A measurement of the quantity of active principle contained in this layer is derived from a measurement of the conductivity of this layer. The measurement device comprises a) first (7) and second (10) electrodes placed on either side of and in electrical contact with at least a part of the layer (2) of the impregnated material of the reservoir, b) means (5) for passing the electric current of predetermined strength through the impregnated material and c) means (6) sensitive to the voltage (V) picked up between the electrodes (7, 10) in order to calculate the quantity of active principle contained in the reservoir.

Abstract: The present invention relates to a new self-adhesive transdermal matrix system for the administration of a hormone by percutaneous route, said system which comprises a support and self-adhesive matrix, having a matrix comprising:(a) 40 to 60 parts by weight of an ethylene/vinyl acetate copolymer,(b) 5 to 20 parts by weight of a cellulosic material,(c) 35 to 55 parts by weight of at least one compound selected from the group consisting of: crotamiton, N-substituted 2-pyrrolidones of the formula I, ##STR1## in which the R group represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group, and higher C.sub.12 -C.sub.20 aliphatic alcohols, and(d) 0,01 to 7 parts by weight of a hormone selected from the group consisting of estrogen components, progestogen components and mixtures thereof.It also relates to a method for preparing this transdermal matrix system.

Abstract: This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing:(a) 20 to 42 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer,(b) 35 to 55 parts by weight of a tackifying resin.(c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5-oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol,(d) 5 to 15 parts by weight of at least one compound selected from the group consisting of:crotamiton, andN-substituted 2-pyrrolidones of formula I, ##STR1## wherein R represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group,(e) 0,01 to 1 part by weight of a stabilizing agent and,(f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof.

Abstract: A dressing with thinned edges comprising a support and an adhesive system of reducing thickness in the direction of the periphery and a process of making the dressing. The process includes the formation of an adhesive system consisting of at least two adhesive layers which are:(i) superimposed to form a set of reducing surface areas from the base, joined to the support, to the top, and(ii) arranged in such a way that two adjacent adhesive layers are joined together and have different surface areas, the edges of one of the two adjacent adhesive layers being offset relative to the edges of the other adhesive layer, the adhesive layer forming the base of the adhesive system, which is joined to the support, having a surface area which is (a) identical to that of the support and (b) greater than the surface area of every other layer of the adhesive system.

Abstract: The present invention relates to a dressing comprising a mixture of block copolymer with a saturated central sequence and plasticizer. The saturated central sequence has three sequences wherein the structure at each block is a polystyrene terminal block and the central sequence is a saturated polyolefin block.

Abstract: A process is disclosed for preparing a thermoplastic composition having elastic memory and containing polyurethane interlocked in a network of polycaprolactone. The product of the aforementioned process is particularly useful as orthopedic cast or immobilizing device.

Abstract: The present invention relates to a novel self-adhesive matrix for the percutaneous administration of a pharmaceutical active ingredient. This matrix comprises a combination of the following:(a) 30 to 50 parts by weight of an ethylene/vinyl acetate copolymer material,(b) 20 to 45 parts by weight of a higher aliphatic monoalcohol compound,(c) 5 to 20 parts by weight of a cellulose derivative material,(d) 1 to 20 parts by weight of an ester compound of a polyhydric alcohol with a fatty aliphatic acid, and(e) 0.1 to 20 parts by weight of an active ingredient which can be administered percutaneously.

Abstract: The present invention relates to a packing case comprising a box, a heat-retractable plastic and at least one lid, for storing, handling and transporting a charge.In the said case, the heat-retractable plastic (2, 22) in sheet form is bonded at one or more of its edges (32, 322) to the outer surface of a wall (3) of the said box, in the vicinity of the side of the said wall, and extends, on the outside, from the said edge (32, 322) to the side of the said wall and then inside the box, opposite the inner surface of the said wall, moving away from the latter towards the charge which is to be packed.In the said case, the charge is held down against the bottom by means of the heat-retractable plastic along an overlapping zone.