Abstract: This system comprises a compacted bag, in particular under vacuum, having an appendage into which a spacer device is inserted (2) which forms a pocket (140) separating two facing flexible partition sections from each other (120,121) of which one (121) is adapted to be applied when placed under vacuum against a set of heatable blades with closed outline linked to each other (51, 61) the interior blade (61) being carried by a mobile part (6) of which the end is able to penetrate into the cut pocket (140) with a view to the inflation of the bag with air brought by a channel (600′) through a sterilizing filter (8).

Abstract: The present invention provides a device for the dropwise delivery of a fluid (6) contained in a flexible vial (4; 4'), the device comprising a tubular case (1) capable of surrounding the vial (4; 4'), which casing is provided with a bottom portion (2; 7) whose inner surface lies opposite the outer surface of the bottom wall (42; 42') of the vial (4; 4'), the bottom portion (2; 7) of the casing (1) being equipped with a resiliently displaceable tab (3; 8) which can be moved so as to press against the bottom wall (42; 42') of the vial (4; 4') in order to squeeze the vial (4; 4') and drive out a drop (60) of fluid.

Abstract: The present invention concerns a fluid pharmaceutical composition intended to be brought into contact with a physiological fluid, characterized in that it contains, as active principle, at least one 4-quinolone derivative complexed with a divalent metal ion selected from Cu.sup.++, Zn.sup.++ and Mg.sup.++, the said complex being in the form of particles of a size compatible with parenteral or ophthalmic administration, in suspension in a fluid dispersant and not being subject to a crystalline growth phenomenon during storage of the said composition; the invention also provides a process for preparing a pharmaceutical composition of this type.

Abstract: A sterile packaging assembly (100) for dispensing a liquid in drops comprises a main body (101) of plastic material, having a top portion (103) with an outside thread for receiving a screw cap (104), the top portion ending in an elongate neck, constituting a dispensing portion which is surmounted by a closure head (110) that can be torn off in order to define a dispensing orifice (111) on first utilization of the packaging assembly. The invention is particularly applicable to sterile packaging of pharmaceutical substances such as eye drops.

Abstract: A sterile packaging assembly (100) for dispensing a liquid in drops comprises a main body (101) of plastic material, having a top portion (103) with an outside thread for receiving a screw cap (104), and containing a flow rate restriction system (105) for controlling drop formation. The flow rate restriction system is positioned substantially on the axis of the main body and is held in position by a constricted portion (106) of the top portion (103) of the main body. The invention is particularly applicable to sterile packaging of pharmaceutical substances such as eye drops.

Abstract: The present invention concerns a pharmaceutical and/or cosmetic composition designed to be applied on the skin or the mucosae, characterized in that it contains Rhamsan gum.

Abstract: A packaging and dispensing system provides for separate packaging of two ingredients of which at least one is a liquid and for extemporaneous mixing of the two ingredients at the time of first use. The system comprises a first bottle (2) containing the liquid or solid first ingredient and the neck of which is stoppered by a plug (5, 8). It further comprises a second bottle (9) containing the liquid second ingredient and assembled to the first bottle (2) at its neck. There is also an internal coupling member (11) carried by the second bottle (9) and the end of which is coupled to the plug (8). This coupling is obtained automatically when the two bottles are assembled together. A cap (13)screwed onto the second bottle (9) is coupled to the coupling member (11) so that at the time of first use unscrewing the cap (13) initially displaces the plug (8) and establishes automatically the communication between the two bottles without compromising any sterile conditions that may apply.

Abstract: The invention relates to a device for preparing and dispensing a solution. A bottle containing a substance to be disolved is closed by a disc-shaped base having a rigid rod thereon and a deformable head. A tube of solvent is closed by an apertured slidable piston. Mixing is effected by placing the piston against the rigid rod and applying axial pressure which dispenses the solvent from the tube, through a capillary channel in the rod and into the bottle. Slots in the rod are revealed during this operation to allow the air to escape from the bottle. The deformable head also serves to pressurize the bottle to permit dispensing therefrom.

Abstract: The present invention relates to a container which is notably intended to hold pills, and it comprises on the one hand an external, rigid envelope 10 and on the other hand an internal envelope 11 enclosing the pills, this internal envelope being elastically deformable and capable of an increase in volume which is sufficient for absorbing the surplus pressure resulting from the packing of the pills when the lid is applied, without crushing the pills.In a first embodiment, the internal envelope 11 is cylindrical and it has a convex, deformable base 12.In a second embodiment, the internal envelope is a sleeve provided with at least one slit allowing its radial expansion.