Patents Assigned to Laboratoires Serono SA
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Publication number: 20100303760Abstract: The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.Type: ApplicationFiled: April 20, 2006Publication date: December 2, 2010Applicant: Laboratoires Serono SAInventors: Christine Power, Melanie Yorke-Smith
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Patent number: 7696231Abstract: The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.(I).Type: GrantFiled: October 24, 2002Date of Patent: April 13, 2010Assignee: Laboratoires Serono SAInventors: Agnes Bombrun, Patrick Gerber, Denis Church
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Publication number: 20100075402Abstract: A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-? and TPO, linked to a subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.Type: ApplicationFiled: September 26, 2007Publication date: March 25, 2010Applicant: LABORATOIRES SERONO SAInventors: Robert K. Campbell, Bradford A. Jameson, Scott C. Chappel
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Publication number: 20100004167Abstract: The present invention relates to CSF3R polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids encoding said polypeptides, vectors comprising such nucleic acids and recombinant cells containing the same. The invention further discloses methods of producing such polypeptides, as well as methods and tools for detecting or dosing these polypeptides in any sample.Type: ApplicationFiled: July 5, 2007Publication date: January 7, 2010Applicant: Laboratoires Serono SAInventors: Melanie Yorke-Smith, Andreas Pigni
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Patent number: 7638480Abstract: The invention relates to the use of osteoprotegerin for treatment and/or prevention of fibrotic diseases, in particular of scleroderma.Type: GrantFiled: March 26, 2003Date of Patent: December 29, 2009Assignee: Laboratoires Serono SAInventors: Christine Power, Christine Plater-Zyberk
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Patent number: 7635713Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: GrantFiled: November 21, 2007Date of Patent: December 22, 2009Assignee: Laboratoires Serono SAInventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
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Publication number: 20090291091Abstract: It is the object of the present invention to provide novel means for the treatment and/or prevention of thrombosis, tumor implantation, tumor seeding and metastasis. More specifically, the present invention relates to the use of a polypeptide comprising the globular head of Acrp30 for the manufacture of a medicament for treatment and/or prevention of thrombosis-related disorder, an hypertensive disorder of the pregnancy, tumor implantation, tumor seeding and metastasis.Type: ApplicationFiled: June 20, 2006Publication date: November 26, 2009Applicant: Laboratoires Serono SAInventors: Bernard Bihain, Michel Dreano, Jennifer Hantson, Virginie Ogier, Pierre-Alan Vitte, Frances Yen-Potin
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Publication number: 20090285838Abstract: The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.Type: ApplicationFiled: December 22, 2008Publication date: November 19, 2009Applicant: LABORATOIRES SERONO SAInventor: YOLANDE CHVATCHKO
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Patent number: 7592477Abstract: The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of substituted methylene amide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs. Also the present invention relates to a method of treating diabetes type II, obesity and to regulate the appetite of mammals. The present invention is furthermore related to novel substituted methylene amide derivatives and method of preparation thereof. Formula (I).Type: GrantFiled: January 27, 2003Date of Patent: September 22, 2009Assignee: Laboratoires Serono SAInventors: Dominique Swinnen, Agnes Bombrun, Jerome Gonzalez, Patrick Gerber, Pierre-Andre Pittet
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Publication number: 20090221575Abstract: The present invention is related to sulfonamide derivatives of Formula (Ia) where the groups are as defined in the description, and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.Type: ApplicationFiled: October 24, 2006Publication date: September 3, 2009Applicant: Laboratoires Serono SAInventors: Patrick Gerber, Dominique Swinnen, Agnes Bombrun
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Publication number: 20090176762Abstract: This invention relates to the use of a JNK inhibitor for treating and/or preventing skin diseases selected from psoriasis and dermatitis.Type: ApplicationFiled: June 1, 2007Publication date: July 9, 2009Applicant: LABORATOIRES SERONO SAInventors: Chiara Ferrandi, Jean-Pierre Gotteland, Christoph H. Ladel, Paola Zaratin
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Patent number: 7557136Abstract: The present invention relates to novel pyrrolidine derivatives of Formula (I), its geometrical isomers, its optically active forms as enantiomers, diastercomers, mixtures of these and its racemate forms, as well as salts thereof, wherein: R1is selected from the group comprising or consisting of H and C1-C6-alkyl; R2 is selected from the group comprising or consisting of hydrogen, C1-C6-alkyl, C1-C6 alkyl aryl, heteroaryl, C1-C6 alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6 alkenyl heteroaryl, C2-C6-alkynyl, C2-C6-alkynyl aryl, C2C6-alkynyl heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, CI-C6-alkyl cycloallcyl, CI-C6-alkyl heterocycloalkyl, CIC6 alkyl carboxy, acyl, C1-C6-alkyl acyl, C1-C6-alkyl acyloxy, C1-C6-alkyl alkoxy, alkoxycarbonyl, C1-C6-alkyl alkoxycarbonyl, aminocarbonyl, C1-C6-alkyl aminocarbonyl, C1-C6-alkyl acylarnino, C1-C6-alkyl ureido, amino, C1-C6-alkyl amino, sulfonyloxy, C1-C6 alkyl sulfonyloxy, sulfonyl, C1-C6-alkyl sulfonyl, sulfinyl, C1-C6-alkyl sulfinyl, C1-C6alkyl sulfanylType: GrantFiled: February 16, 2004Date of Patent: July 7, 2009Assignee: Laboratoires Serono SAInventors: Matthias Schwarz, Catherine Jorand-Lebrun, Delphine Valognes
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Patent number: 7550563Abstract: The present invention relates to a method for the purification of non-immunoglobulin proteins comprising one or more immunoglobulin-like (Ig-like) domain.Type: GrantFiled: August 5, 2004Date of Patent: June 23, 2009Assignee: Laboratoires Serono SAInventors: Boris Schwartsburd, Ilana Belzer
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Patent number: 7544700Abstract: The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble. Said compounds are notably for use as pharmaceutically active compounds. The present invention also related to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation.Type: GrantFiled: September 27, 2001Date of Patent: June 9, 2009Assignee: Laboratoires Serono SAInventors: Serge Halazy, Dennis Church, Stephen J. Arkinstall, Marco Biamonte, Montserrat Camps, Jean-Pierre Gotteland, Thomas Rueckle
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Patent number: 7541375Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.Type: GrantFiled: July 24, 2007Date of Patent: June 2, 2009Assignee: Laboratoires Serono SAInventors: Stephen J. Arkinstall, Antonio Arulanandam, Xuliang Jiang, Sharad Magar, Roustem Nabioullin, John Yingsheng Zhang, Peter Blume-Jensen
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Patent number: 7507707Abstract: The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.Type: GrantFiled: December 14, 2001Date of Patent: March 24, 2009Assignee: Laboratoires Serono SAInventors: Stephen Palmer, Mark Tepper, Sean McKenna, Michael C. MacNamee, Aliza Eshkol
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Publication number: 20090035274Abstract: The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.Type: ApplicationFiled: April 20, 2006Publication date: February 5, 2009Applicant: Laboratoires Serono SAInventors: Christine Power, Melanie Yorke-Smith
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Publication number: 20090029997Abstract: The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.Type: ApplicationFiled: January 22, 2007Publication date: January 29, 2009Applicant: LABORATOIRES SERONO SAInventors: Anna Quattropani, Vincent Pomel, Thomas Rueckle, Tania Grippi-Vallotton
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Patent number: 7479575Abstract: The present invention is related to a new synthesis for preparing para-phenyl alkynyl benzaldehyde of general formula (I). The compounds of formula (I) are useful building blocks, in particular in the synthesis of electrically conducting polymers. R is selected from the group consisting of C1-C12-alkyl, C1-C12-alkyl aryl, C1-C12-alkyl heteroaryl, C2-C12-alkenyl, C2C12-alkenyl aryl, C2-C12-alkenyl heteroaryl, C2-C12-alkynyl, C2-C12-alkynyl aryl, C2-C12-alkynyl heteroaryl, C3-C8-cycloalkylC1-C12-alkyl-C3-C8-cycloalkyl, C1-C12-alkoxy, aryl, heteroaryl, halides.Type: GrantFiled: October 12, 2004Date of Patent: January 20, 2009Assignee: Laboratoires Serono SAInventors: Dominique Swinnen, Danig Pohin
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Patent number: 7479486Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.Type: GrantFiled: May 6, 2005Date of Patent: January 20, 2009Assignee: Laboratoires Serono SAInventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro