Abstract: The invention relates to novel derivatives of tetrahydro-2,3,6,7,1H,5H,11H-(1)benzopyrano(6,7,8ij)quinolizinone in accordance with the formula: ##STR1## in which R.sup.1 represents 1) --NH--(CH.sub.2).sub.n --R.sup.2 with n being an integer between 1 and 20 and R.sup.2 representing --N.dbd.C.dbd.S or NH--CO--CH.sub.2 X with X representing I, Br or Cl, or2) --NH--(CH.sub.2 --CH.sub.2 --O)m--CH.sub.2 --CH.sub.2 --R.sup.3 with m being an integer between 1 and 30 and R.sup.3 representing a group chosen from among groups of formula ##STR2## in which p is an integer from 1 to 10 and X represents Br, Cl or I. These derivatives can be use as markers for organic compounds, in particular biological substances, for the detection thereof by chemiluminescence or fluorescence.
Type:
Grant
Filed:
November 27, 1990
Date of Patent:
September 29, 1992
Assignee:
Laboratories Eurobio
Inventors:
Pierre Reveilleau, Georges Mahuzier, Joseph Chalom, Robert Farinotti, Michel Tod, Edith Barre
Abstract: The invention concerns new derivatives of tetrahydro-2,3,6,7,1H,5H,11H-(1)benzopyrano(6,7,8, ij)quinolizinone in accordance with formula: ##STR1## in which R.sup.1 represents a radical having formula: ##STR2## wherein m is equal to 0 or 1, and n is equal to 0 or is a whole number from 1 to 12, provided that n is equal to 0 when m is 0, or the radical having the formula:--NH--(CH.sub.2).sub.n --NH.sub.2,in which n has the above meaning.Said derivatives can be used as markers for organic compounds, in order to detect them by chemiluminescence or fluorescence.
Type:
Grant
Filed:
January 31, 1991
Date of Patent:
January 21, 1992
Assignee:
Laboratories Eurobio
Inventors:
Georges Mahuzier, Joseph Chalom, Robert Farinotti, Michel Tod