Abstract: The invention provides processes using suspensions to produce fenofibrate compositions. The resulting fenofibrate compositions can be made in the form of a capsule.
Abstract: The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.
Type:
Grant
Filed:
March 24, 2006
Date of Patent:
April 3, 2012
Assignee:
Laboratories Fournier S.A.
Inventors:
Véronique Barberousse, Michel Bondoux, Didier Thomas, Vincent Peyrou
Abstract: The present invention relates to a compound derived from indole, especially a therapeutically useful compound, characterized in that it is selected from compounds of formula (I) in which R1 represents a halogen or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, R3 represents an isopropyl (1-methylethyl) group or a tert-butyl (1,1-dimethylethyl) group and n=3 or 4 and pharmaceutically acceptable salts of said compounds of formula (I). Application: Treatment of neurodegenerative diseases and more particularly of Parkinson's disease.
Type:
Application
Filed:
July 9, 2009
Publication date:
July 21, 2011
Applicant:
Laboratories Fournier S.A.
Inventors:
Benaissa Boubia, Johannes Bernard Van Vliet, Joseph Antonius Jacobus Den Hartog, Andrew McCreary, Mireille Tallander, Petronella Johanna Maria Van Dongen, Olivia Poupardin-Olivier
Abstract: Benzenesulfonamide derivative compounds corresponding to the general formula (I): and their pharmaceutically acceptable addition salts; a process for preparation of such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds as a pharmacologically active substance, in particular in the treatment of neurodegenerative diseases, cardiovascular diseases, inflammatory diseases; hypercholesterolemia, and diabetes.
Type:
Grant
Filed:
November 7, 2006
Date of Patent:
January 18, 2011
Assignee:
Laboratories Fournier S.A.
Inventors:
Luc Lebreton, Christine Massardier, Christine Dumas, Pierre Dodey, Philippe Masson
Abstract: Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.
Type:
Application
Filed:
June 7, 2010
Publication date:
November 11, 2010
Applicant:
Laboratories Fournier S.A.
Inventors:
Jean BINET, Benaïssa Boubia, Pierre Dodey, Christiane Legendre, Martine Barth, Olivia Poupardin-Olivier
Abstract: Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.
Type:
Grant
Filed:
February 28, 2008
Date of Patent:
September 14, 2010
Assignee:
Laboratories Fournier S.A.
Inventors:
Jean Binet, Benaiessa Boubia, Pierre Dodey, Christiane Legendre, Martine Barth, Olivia Poupardin-Olivier
Abstract: Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances, particularly for the treatment or inhibition of neurodegeneration, cardiovascular disease, inflammatory disease, hypercholesterolemia, dyslipidemia, obesity or diabetes.
Type:
Application
Filed:
November 30, 2007
Publication date:
May 22, 2008
Applicant:
Laboratories Fournier S.A.
Inventors:
Luc LEBRETON, Christine Dumas, Christine Massardier, Michel Bondoux
Abstract: The invention provides compositions comprising micronized fenofibrate, where the compositions have a dissolution of at least 10% in 5 minutes, 20% in 10 minutes, 50% in 20 minutes and 75% in 30 minutes, as measured using the rotating blade method at 75 rpm according to the European Pharmacopoeia, in a dissolution medium constituted by water with 2% by weight polysorbate 80 or 0.025 M sodium lauryl sulfate.