Patents Assigned to Lavipharm Laboratories Inc.
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Publication number: 20070298090Abstract: Dosage forms of a nicotine delivery system are disclosed in which a mucoadhesive film, made up of one or more non-microbial hydrocolloid(s) and an effective dose of nicotine, dissolves when applied intraorally to release the nicotine which is absorbed through the oramucosac and directly reaches systemic circulation. Methods for preparing various versions of the dosage forms are disclosed. Methods to assist smoking cessation or provide substitutes for smoking by administrating the dosage form are also provided.Type: ApplicationFiled: September 7, 2007Publication date: December 27, 2007Applicant: LAVIPHARM LABORATORIES, INC.Inventors: Li-Lan CHEN, Alfred LIANG
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Patent number: 7247315Abstract: The invention relates to transdermal delivery patches comprising a drug-containing drug reservoir wherein the drug reservoir comprises a plasticizer composition selected to adjust the rate of drug flux out of the transdermal delivery patch device. The invention also specifically relates to methods of producing the transdermal delivery patches of the invention, the methods comprising the use of an alcohol drug dispersing agent. The invention further specifically relates to methods of treating acute and chronic pain and methods of inducing and maintaining analgesia with the transdermal delivery patches of the invention.Type: GrantFiled: August 15, 2002Date of Patent: July 24, 2007Assignee: Lavipharm Laboratories Inc.Inventors: Teletha A. Brown, James Osborne, Michael Rudella, Brian Hunt, Vinod Malik
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Publication number: 20070087981Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.Type: ApplicationFiled: October 19, 2006Publication date: April 19, 2007Applicant: Lavipharm Laboratories, Inc.Inventors: Li-Lan Chen, Li Tao, Alfred Liang
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Patent number: 7138135Abstract: Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.Type: GrantFiled: June 24, 2004Date of Patent: November 21, 2006Assignee: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang, Xu Zheng
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Patent number: 7125564Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.Type: GrantFiled: February 8, 2002Date of Patent: October 24, 2006Assignee: Lavipharm Laboratories, Inc.Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang
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Patent number: 7087240Abstract: Devices and methods for treatment of erectile dysfunction and methods of manufacture and of use are provided. The devices include filmogenic material, a therapeutic agent, a permeation enhancer, and other ingredients. An embodiment of the device includes a backing and a release liner.Type: GrantFiled: June 25, 1999Date of Patent: August 8, 2006Assignee: Lavipharm Laboratories Inc.Inventor: Spiros Fotinos
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Patent number: 6723671Abstract: Fragrance emitting articles are provided along with methods of making and using the same. The fragrance emitting articles provided contain microcapsules of a fragrance, which microcapsules are associated with the fragrance emitting article without the addition of a binder. The invention also relates to methods of making the subject fragrance emitting articles and methods of using those articles.Type: GrantFiled: April 13, 2001Date of Patent: April 20, 2004Assignee: Lavipharm Laboratories Inc.Inventors: Yelena Zolotarsky, David O'Halloran, Florence Bernard, Pradeep Thaker
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Publication number: 20040013731Abstract: Oral drug complex microparticles containing: a pharmaceutical active having a nitrogen moiety and an anionic methacrylic acid copolymer; wherein the oral drug complex micropaticles resist dissolution or dissociation upon exposure to saliva, but which rapidly dissociate in gastric acid and which rapidly dissolve in intestinal fluid. Oral drug delivery devices containing said oral drug complex microparticles are provided. Processes for producing said oral drug complex microparticles and methods for treating patients including administering said oral drug delivery devices thereto are also provided.Type: ApplicationFiled: April 8, 2003Publication date: January 22, 2004Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Alfred Liang, Xu Zheng
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Publication number: 20030219479Abstract: Drug delivery devices for administering an active agent or a combination of active agents to a subject are provided.Type: ApplicationFiled: April 8, 2003Publication date: November 27, 2003Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Alfred Liang
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Publication number: 20030118653Abstract: Quick dissolving oral mucosal drug delivery devices having a mucosal surface-coat-forming inner layer disposed between two moisture barrier coating layers for administering an active agent or combination of active agents to a subject are provided. Methods for making such quick dissolving oral mucosal drug delivery devices and to methods for using such quick dissolving oral mucosal drug delivery devices offering the measured and controlled release of an active agent or combination of active agents to a subject are also provided.Type: ApplicationFiled: June 10, 2002Publication date: June 26, 2003Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Alfred Liang, Xu Zheng, Hsueh-Ling Wu
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Publication number: 20030086954Abstract: Compositions for forming a peelable, cosmetic film on the skin of a subject are provided. The compositions provided contain 3 to 30 wt % pullulan and 3 to 30 wt % polyvinyl alcohol; wherein the combination of pullulan and polyvinyl alcohol constitute 6 to 33 wt % of the composition. The invention also relates to a method of forming a peelable, cosmetic film on the skin of a subject including applying a composition to the skin of the subject, wherein the composition contains 3 to 30 wt % pullulan and 3 to 30 wt % polyvinyl alcohol; wherein the combination of pullulan and polyvinyl alcohol constitute 6 to 33 wt % of the composition.Type: ApplicationFiled: September 26, 2002Publication date: May 8, 2003Applicant: Lavipharm Laboratories Inc.Inventors: David P. O'Halloran, Yelena Zolotarsky
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Publication number: 20030082221Abstract: Compositions for forming a visible and distinctive cosmetic film on the skin of a subject are provided. The compositions provided contain 3 to 15 wt % pullulan. The invention also relates to a method of forming a visible and distinctive cosmetic film on the skin of a subject including applying a composition to the skin of the subject, wherein the composition contains 3 to 15 wt % pullulan.Type: ApplicationFiled: September 26, 2002Publication date: May 1, 2003Applicant: Lavipharm Laboratories Inc.Inventors: David P. O'Halloran, Yelena Zolotarsky
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Patent number: 6552024Abstract: Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.Type: GrantFiled: November 5, 1999Date of Patent: April 22, 2003Assignee: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, William R. Pfister, Donald W. Renn, Thitiwan Buranachokpaisan, James Osborne, Hock Seng Tan, Li Tao
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Publication number: 20030068378Abstract: Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of a sexual dysfunction active agent and a mucosal adhesion enhancer, wherein the mucosal adhesion enhancer is a starch graft copolymer.Type: ApplicationFiled: March 5, 2002Publication date: April 10, 2003Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, William R. Pfister, Donald W. Renn, Thitiwan Buranachokpaisan, James Osborne, Hock Seng Tan, Li Tao
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Publication number: 20030068376Abstract: Dosage forms of a nicotine delivery system are disclosed in which a mucoadhesive film, made up of one or more non-microbial hydrocolloid(s) and an effective dose of nicotine, dissolves when applied intraorally to release the nicotine which is absorbed through the oramucosae and directly reaches systemic circulation. Methods for preparing various versions of the dosage forms are disclosed. Methods to assist smoking cessation or provide substitutes for smoking by administrating the dosage form are also provided.Type: ApplicationFiled: April 18, 2002Publication date: April 10, 2003Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Alfred Liang
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Publication number: 20030060479Abstract: The invention relates to transdermal delivery patches comprising a drug-containing drug reservoir wherein the drug reservoir comprises a plasticizer composition selected to adjust the rate of drug flux out of the transdermal delivery patch device. The invention also specifically relates to methods of producing the transdermal delivery patches of the invention, the methods comprising the use of an alcohol drug dispersing agent. The invention further specifically relates to methods of treating acute and chronic pain and methods of inducing and maintaining analgesia with the transdermal delivery patches of the invention.Type: ApplicationFiled: August 15, 2002Publication date: March 27, 2003Applicant: Lavipharm Laboratories Inc.Inventors: Teletha A. Brown, James Osborne, Michael Rudella, Brian Hunt, Vinod Malik
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Publication number: 20030007944Abstract: Cosmetic and/or therapeutic film former compositions for a topical use and for optional delivery of active ingredients to the skin are provided. More particularly, film forming compositions are provided, containing 1 to 50 wt % polyurethane, preferably polyurethane-1; at least 0.01 wt %, but less than 2.0 wt %, cellulose and 0.05 to 5.0 wt % magnesium aluminum silicate; wherein the film forming composition forms a uniform mist when discharged from a spray bottle or pump sprayer. A method for applying a film forming composition to an individual's skin is also provided including spraying the film forming composition onto the skin, wherein the film forming composition contains 1 to 50 wt % polyurethane; at least 0.01 wt %, but less than 2.0 wt %, cellulose and 0.05 to 5.0 wt % magnesium aluminum silicate; and wherein the film forming composition forms a uniform mist when sprayed.Type: ApplicationFiled: April 3, 2002Publication date: January 9, 2003Applicant: Lavipharm Laboratories Inc.Inventors: David O'Halloran, Yelena Zolotarsky
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Publication number: 20020147201Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.Type: ApplicationFiled: February 8, 2002Publication date: October 10, 2002Applicant: Lavipharm Laboratories Inc.Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang
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Publication number: 20020127254Abstract: Solid gel film compositions for local and systemic delivery of active substances through the skin or mucosal epithelial layer of a subject are provided. More particularly, delivery discs are provided containing a uniform mixture, wherein the uniform mixture contains a filmogenic polymer and a therapeutically effective dose of an active substance, wherein the delivery disc is a single uniform layer device which is non-tacky and which dissolves onto a skin tissue skin tissue with few drops of water or lotion or mucosal epithelial tissue of a subject when applied thereto. Methods for administering an active substance to a subject using a delivery disc of the present invention are provided. Methods for preparing the delivery discs of the present invention are also provided.Type: ApplicationFiled: January 7, 2002Publication date: September 12, 2002Applicant: Lavipharm Laboratories Inc.Inventors: Spiros Fotinos, David O 'Halloran, Yelena Zolotarsky
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Patent number: 6346255Abstract: Devices for the improvement of skin appearance are provided, said devices including a pad with a backing layer, a release layer, and a vehicle located therebetween, the vehicle containing a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. The invention also relates to a method of improving skin appearance using the devices of the invention.Type: GrantFiled: January 15, 1999Date of Patent: February 12, 2002Assignee: Lavipharm Laboratories Inc.Inventor: Spiros Fotinos