Patents Assigned to Le Centre National de la Recherche Scientifique
  • Patent number: 7829724
    Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: November 9, 2010
    Assignees: Zentaris GmbH, Le Centre National de la Recherche Scientifique, University of Montpellier I, University of Montpellier II
    Inventors: Daniel Perrissoud, Jean Martinez, Aline Moulin, Jean-Alain Fehrentz, Damien Boeglin, Luc Demange
  • Publication number: 20100222943
    Abstract: The flight control system comprises: at least one actuator (13) for a mobile surface of the said aircraft; a flight control module (12) in communication with the said actuator (13), the said module comprising at least a first and a second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), each computer being adapted for calculating a control command established according to at least one predetermined law for control of the said flight surface; the said actuator (13) comprising logical means (18, 19) adapted for comparing the commands of the said computers (14-1, 14-2, 14-3, 15-1, 15-2, 15-3) and for determining on the basis of these commands the action to be executed on the said mobile surface. The aircraft comprises such a system.
    Type: Application
    Filed: January 15, 2010
    Publication date: September 2, 2010
    Applicants: Airbus Operations (S.A.S.), Le Centre National De La Recherche Scientifique
    Inventors: Manel SGHAIRI, Patrice Brot, Jean-Jacques Aubert, Agnan De Bonneval, Yves Crouzet
  • Publication number: 20100204853
    Abstract: The flight control system comprises: at least one actuator (13) for a mobile flight surface of the said aircraft; a flight control module (12) in communication with the said actuator (13), the said module comprising a first and a second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), each computer being adapted for calculating a control command established according to at least one predetermined law for control of the said flight surface; the said first computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), known as validating computer, comprising logic means adapted for comparing its control command with that of the said second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), known as master computer, and for transmitting the result of the said comparison to the said actuator (13), the said actuator (13) comprising logic means (18, 19) adapted for deciding, on the basis of this result, to execute or not to execute the command of the master computer. The aircraft comprises such a system.
    Type: Application
    Filed: January 20, 2010
    Publication date: August 12, 2010
    Applicants: Airbus Operations (S.A.S), Le Centre National De La Recherche Scientifique
    Inventors: Manel Sghairi, Patrice Brot, Jean-Jacques Aubert, Agnan De Bonneval, Yves Crouzet
  • Patent number: 7618747
    Abstract: The invention provides a new route for the synthesis of carbon-coated powders having the olivine or NASICON structure, which form promising classes of active products for the manufacture of rechargeable lithium batteries. Carbon-coating of the powder particles is necessary to achieve good performances because of the rather poor electronic conductivity of said structures. For the preparation of coated LiFePO4, sources of Li, Fe and phosphate are dissolved in an aqueous solution together with a polycarboxylic acid and a polyhydric alcohol. Upon water evaporation, polyesterification occurs while a mixed precipitate is formed containing Li, Fe and phosphate. The resin-encapsulated mixture is then heat treated at 700° C. in a reducing atmosphere. This results in the production of a fine powder consisting of an olivine LiFePO4 phase, coated with conductive carbon.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: November 17, 2009
    Assignees: Umicore, Le Centre National de la Recherche Scientifique
    Inventors: Albane Audemer, Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
  • Publication number: 20090268901
    Abstract: A continuous variable quantum encryption key distribution system comprises a sender (Alice) able to randomly choose the phase and the amplitude of each coherent light pulse of a signal, to provide a coherent state defined by a first quadrature and a second quadrature that are random, and to transmit to a receiver (Bob) the signal pulses (S) and a local oscillator (LO), the receiver comprising a homodyne detector (36) for measuring a randomly chosen quadrature of a signal pulse. The sender comprises a device for time-division multiplexing the pulses of the signal (S) and of the local oscillator (LO) to handle the transmission over an optical fiber (10) of the signal and local oscillator pulses to the receiver. The receiver comprises a demultiplexer (31), able to send the received pulses over a first channel (32), or over a second channel (33). The channels are applied as inputs to the homodyne detector (36).
    Type: Application
    Filed: December 15, 2005
    Publication date: October 29, 2009
    Applicants: Thales, Le Centre National De La Recherche Scientifique
    Inventors: Jerome Lodewyck, Thierry Debuisschert, Rosa Tualle-Brouri, Philippe Grangier
  • Publication number: 20090111024
    Abstract: Methods of manufacture and use of phosphates of transition metals are described as positive electrodes for secondary lithium batteries, including a process for the production of LiMPO4 with controlled size and morphology, M being FexCoyNizMnw, where 0?x?1, 0?y?1, 0?w?1, and x+y+z+w=1. According to an exemplary embodiment, a process is described for the manufacture of LiFePO4 including the steps of providing an equimolar aqueous solution of Li1+, Fe3+ and PO43?, evaporating water from the solution to produce a solid mixture, decomposing the solid mixture at a temperature of below 500° C. to form a pure homogeneous Li and Fe phosphate precursor, and annealing the precursor at a temperature of less than 800° C. in a reducing atmosphere to produce the LiFePO4 powder. The obtained powders can have a particle size of less than 1 ?m, and can provide superior electrochemical performance when mixed for an appropriate time with an electrically conductive powder.
    Type: Application
    Filed: April 11, 2007
    Publication date: April 30, 2009
    Applicants: Le Centre National de la Recherche Scientifique, Umicore
    Inventors: Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
  • Publication number: 20090072203
    Abstract: The invention provides a new route for the synthesis of carbon-coated powders having the olivine or NASICON structure, which form promising classes of active products for the manufacture of rechargeable lithium batteries. Carbon-coating of the powder particles is necessary to achieve good performances because of the rather poor electronic conductivity of said structures. For the preparation of coated LiFePO4, sources of Li, Fe and phosphate are dissolved in an aqueous solution together with a polycarboxylic acid and a polyhydric alcohol. Upon water evaporation, polyesterification occurs while a mixed precipitate is formed containing Li, Fe and phosphate. The resin-encapsulated mixture is then heat treated at 700° C. in a reducing atmosphere. This results in the production of a fine powder consisting of an olivine LiFePO4 phase, coated with conductive carbon.
    Type: Application
    Filed: November 14, 2008
    Publication date: March 19, 2009
    Applicants: Umicore, Le Centre National de la Recherche Scientifique
    Inventors: Albane AUDEMER, Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
  • Patent number: 7430351
    Abstract: The invention relates to a non-linear optical filter capable of transmitting an electromagnetic pulse with a duration of less than about 1 picosecond, provided with means for generating an electromagnetic field E with a linear polarization from this pulse, and with a crystal C1 of cubic geometry capable of generating an electromagnetic field E?1 from E with a linear polarization orthogonal to that of E. It comprises means for generating at least one other electromagnetic field E?2 capable of producing constructive interferences with the electromagnetic field E?1.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: September 30, 2008
    Assignees: Thales, Le Centre National de la Recherche Scientifique, Ecole Polytechnique, Ecole Nationale Superieure des Techniques Avancees
    Inventors: Olivier Albert, Jean Etchepare, Aurélie Jullien, Gilles Cheriaux, Nikolay Minkovski, Solomon Saltiel
  • Patent number: 7371482
    Abstract: Methods of manufacture and use of phosphates of transition metals are described as positive electrodes for secondary lithium batteries, including a process for the production of LiMPO4 with controlled size and morphology, M being FexCoyNizMnw, where 0?x?1,0?y?1, 0?w?1, and x+y+z+w=1. According to an exemplary embodiment, a process is described for the manufacture of LiFePO4 including the steps of providing an equimolar aqueous solution of Li1+, Fe3+ and PO43?, evaporating water from the solution to produce a solid mixture, decomposing the solid mixture at a temperature of below 500° C. to form a pure homogeneous Li and Fe phosphate precursor, and annealing the precursor at a temperature of less than 800° C. in a reducing atmosphere to produce the LiFePO4 powder. The obtained powders can have a particle size of less than 1 ?m, and can provide superior electrochemical performance when mixed for an appropriate time with an electrically conductive powder.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: May 13, 2008
    Assignees: Le Centre National de la Recherche Scientifique, Umicore
    Inventors: Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
  • Publication number: 20070208061
    Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).
    Type: Application
    Filed: August 11, 2006
    Publication date: September 6, 2007
    Applicants: ZENTARIS GmbH, Le Centre National De La Recherche Scientifique
    Inventors: Daniel PERRISSOUD, Jean MARTINEZ, Aline MOULIN, Jean-Alain FEHRENTZ, Damien BOEGLIN, Luc DEMANGE
  • Publication number: 20070037857
    Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).
    Type: Application
    Filed: August 11, 2006
    Publication date: February 15, 2007
    Applicants: ZENTARIS GmbH, Le Centre National De La Recherche Scientifique, University of Montpellier I, University of Montpellier II
    Inventors: Daniel Perrissoud, Jean Martinez, Aline Moulin, Jean-Alain Fehrentz, Damien Boeglin, Luc Demange
  • Publication number: 20060170858
    Abstract: The invention relates to a non-linear optical filter capable of transmitting an electromagnetic pulse with a duration of less than about 1 picosecond, provided with means for generating an electromagnetic field E with a linear polarization from this pulse, and with a crystal C1 of cubic geometry capable of generating an electromagnetic field E?1 from E with a linear polarization orthogonal to that of E. It comprises means for generating at least one other electromagnetic field E?2 capable of producing constructive interferences with the electromagnetic field E?1.
    Type: Application
    Filed: November 30, 2005
    Publication date: August 3, 2006
    Applicants: THALES, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE POLYTECHNIQUE, ECOLE NATIONALE SUPERIEURE DES TECHNIQUES AVANCEES
    Inventors: Olivier Albert, Jean Etchepare, Aurelie Jullien, Gilles Cheriaux, Nikolay Minkovski, Solomon Saltiel
  • Patent number: 6852507
    Abstract: Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: February 8, 2005
    Assignees: Le Centre National de la Recherche Scientifique
    Inventors: Martine Cerutti, Hassan Chaabihi, Gerard Devauchelle, Laurent Gauthier, Michel Kaczorek, Marie-Paule LeFranc, Marie-Alix Poul
  • Patent number: 6803229
    Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: October 12, 2004
    Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche Scientifique
    Inventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
  • Patent number: 6562577
    Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: May 13, 2003
    Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche Scientifique
    Inventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
  • Patent number: 6355436
    Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: March 12, 2002
    Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche Scientifique
    Inventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
  • Patent number: 5972952
    Abstract: The invention relates to pharmaceutical compositions for neuroprotection containing the compound (1S,2R) 1-[1-(2-thienyl)-2-alkylcyclohexyl]piperidine or (1S,2R) 1-[1-(2-furanyl)-2-alkylcyclohexyl]piperdine, or their pharmaceutically acceptable salts. The synthesis and method separation of racemic mixtures to provide pure enantiomers is presented. The compositions have use in the treatment of stroke, CNS trauma and Alzheimer's disease.
    Type: Grant
    Filed: December 10, 1996
    Date of Patent: October 26, 1999
    Assignee: Le Centre National De La Recherche Scientifique
    Inventors: Jean-Marc Kamenka, Martine Michaud, Marie-Jeanne Drian, Jacques Vignon, Alain Privat
  • Patent number: 5338675
    Abstract: A novel toxin of the genus Hirsutella which is useful in controlling invertebrate pests.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: August 16, 1994
    Assignees: University of Florida, l'Institut National de la Recherche Agronomique (INRA), Le Centre National de la Recherche Scientifique (CNRS)
    Inventors: Clayton W. McCoy, Alain J. Vey, Isabelle M. Mazet
  • Patent number: 4899163
    Abstract: The antenna constituted by a plurality of identical parallel and symmetrical linear sub-networks (a7, a6, . . . a1, a'1, a'2, . . . , a'7). The centres of symmetry (b7, b.notident.b, . . . , b1, b'1, b'2 . . . , b'7) of the sub-networks (a7 to a'7) are aligned on a line (c) perpendicular to their diameter and are fed in phase. Each sub-network is constituted by a plurality of radiating elements in even numbers disposed at regular intervals and which radiate from fields displaced from 180.degree. from one radiating element to the following. The pitch of the sub-network is approximately equal to a wave-length guided on the substrate of the printed circuit. Each radiating element is a conducting square surface the side of which is approximately equal to half the guided wavelength with one corner connected galvanically to the feed line. The direction of the surfaces change from one element to the following element.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: February 6, 1990
    Assignee: Le Centre Regional D'Innovation et de Transfert de Technologie de Bretagne Loi Le Centre National de la Recherche Scientifique, Etablissement Public National a Caractere Scientifique et Technologiqu
    Inventors: Jean-Pierre L. M. Daniel, Phillipe Dupuis, Jean-Luc Alanic