Patents Assigned to Le Centre National de la Recherche Scientifique
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Patent number: 7829724Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).Type: GrantFiled: August 11, 2006Date of Patent: November 9, 2010Assignees: Zentaris GmbH, Le Centre National de la Recherche Scientifique, University of Montpellier I, University of Montpellier IIInventors: Daniel Perrissoud, Jean Martinez, Aline Moulin, Jean-Alain Fehrentz, Damien Boeglin, Luc Demange
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Publication number: 20100222943Abstract: The flight control system comprises: at least one actuator (13) for a mobile surface of the said aircraft; a flight control module (12) in communication with the said actuator (13), the said module comprising at least a first and a second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), each computer being adapted for calculating a control command established according to at least one predetermined law for control of the said flight surface; the said actuator (13) comprising logical means (18, 19) adapted for comparing the commands of the said computers (14-1, 14-2, 14-3, 15-1, 15-2, 15-3) and for determining on the basis of these commands the action to be executed on the said mobile surface. The aircraft comprises such a system.Type: ApplicationFiled: January 15, 2010Publication date: September 2, 2010Applicants: Airbus Operations (S.A.S.), Le Centre National De La Recherche ScientifiqueInventors: Manel SGHAIRI, Patrice Brot, Jean-Jacques Aubert, Agnan De Bonneval, Yves Crouzet
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Publication number: 20100204853Abstract: The flight control system comprises: at least one actuator (13) for a mobile flight surface of the said aircraft; a flight control module (12) in communication with the said actuator (13), the said module comprising a first and a second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), each computer being adapted for calculating a control command established according to at least one predetermined law for control of the said flight surface; the said first computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), known as validating computer, comprising logic means adapted for comparing its control command with that of the said second computer (14-1, 14-2, 14-3, 15-1, 15-2, 15-3), known as master computer, and for transmitting the result of the said comparison to the said actuator (13), the said actuator (13) comprising logic means (18, 19) adapted for deciding, on the basis of this result, to execute or not to execute the command of the master computer. The aircraft comprises such a system.Type: ApplicationFiled: January 20, 2010Publication date: August 12, 2010Applicants: Airbus Operations (S.A.S), Le Centre National De La Recherche ScientifiqueInventors: Manel Sghairi, Patrice Brot, Jean-Jacques Aubert, Agnan De Bonneval, Yves Crouzet
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Patent number: 7618747Abstract: The invention provides a new route for the synthesis of carbon-coated powders having the olivine or NASICON structure, which form promising classes of active products for the manufacture of rechargeable lithium batteries. Carbon-coating of the powder particles is necessary to achieve good performances because of the rather poor electronic conductivity of said structures. For the preparation of coated LiFePO4, sources of Li, Fe and phosphate are dissolved in an aqueous solution together with a polycarboxylic acid and a polyhydric alcohol. Upon water evaporation, polyesterification occurs while a mixed precipitate is formed containing Li, Fe and phosphate. The resin-encapsulated mixture is then heat treated at 700° C. in a reducing atmosphere. This results in the production of a fine powder consisting of an olivine LiFePO4 phase, coated with conductive carbon.Type: GrantFiled: June 19, 2003Date of Patent: November 17, 2009Assignees: Umicore, Le Centre National de la Recherche ScientifiqueInventors: Albane Audemer, Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
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Publication number: 20090268901Abstract: A continuous variable quantum encryption key distribution system comprises a sender (Alice) able to randomly choose the phase and the amplitude of each coherent light pulse of a signal, to provide a coherent state defined by a first quadrature and a second quadrature that are random, and to transmit to a receiver (Bob) the signal pulses (S) and a local oscillator (LO), the receiver comprising a homodyne detector (36) for measuring a randomly chosen quadrature of a signal pulse. The sender comprises a device for time-division multiplexing the pulses of the signal (S) and of the local oscillator (LO) to handle the transmission over an optical fiber (10) of the signal and local oscillator pulses to the receiver. The receiver comprises a demultiplexer (31), able to send the received pulses over a first channel (32), or over a second channel (33). The channels are applied as inputs to the homodyne detector (36).Type: ApplicationFiled: December 15, 2005Publication date: October 29, 2009Applicants: Thales, Le Centre National De La Recherche ScientifiqueInventors: Jerome Lodewyck, Thierry Debuisschert, Rosa Tualle-Brouri, Philippe Grangier
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Publication number: 20090111024Abstract: Methods of manufacture and use of phosphates of transition metals are described as positive electrodes for secondary lithium batteries, including a process for the production of LiMPO4 with controlled size and morphology, M being FexCoyNizMnw, where 0?x?1, 0?y?1, 0?w?1, and x+y+z+w=1. According to an exemplary embodiment, a process is described for the manufacture of LiFePO4 including the steps of providing an equimolar aqueous solution of Li1+, Fe3+ and PO43?, evaporating water from the solution to produce a solid mixture, decomposing the solid mixture at a temperature of below 500° C. to form a pure homogeneous Li and Fe phosphate precursor, and annealing the precursor at a temperature of less than 800° C. in a reducing atmosphere to produce the LiFePO4 powder. The obtained powders can have a particle size of less than 1 ?m, and can provide superior electrochemical performance when mixed for an appropriate time with an electrically conductive powder.Type: ApplicationFiled: April 11, 2007Publication date: April 30, 2009Applicants: Le Centre National de la Recherche Scientifique, UmicoreInventors: Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
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Publication number: 20090072203Abstract: The invention provides a new route for the synthesis of carbon-coated powders having the olivine or NASICON structure, which form promising classes of active products for the manufacture of rechargeable lithium batteries. Carbon-coating of the powder particles is necessary to achieve good performances because of the rather poor electronic conductivity of said structures. For the preparation of coated LiFePO4, sources of Li, Fe and phosphate are dissolved in an aqueous solution together with a polycarboxylic acid and a polyhydric alcohol. Upon water evaporation, polyesterification occurs while a mixed precipitate is formed containing Li, Fe and phosphate. The resin-encapsulated mixture is then heat treated at 700° C. in a reducing atmosphere. This results in the production of a fine powder consisting of an olivine LiFePO4 phase, coated with conductive carbon.Type: ApplicationFiled: November 14, 2008Publication date: March 19, 2009Applicants: Umicore, Le Centre National de la Recherche ScientifiqueInventors: Albane AUDEMER, Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
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Patent number: 7430351Abstract: The invention relates to a non-linear optical filter capable of transmitting an electromagnetic pulse with a duration of less than about 1 picosecond, provided with means for generating an electromagnetic field E with a linear polarization from this pulse, and with a crystal C1 of cubic geometry capable of generating an electromagnetic field E?1 from E with a linear polarization orthogonal to that of E. It comprises means for generating at least one other electromagnetic field E?2 capable of producing constructive interferences with the electromagnetic field E?1.Type: GrantFiled: November 30, 2005Date of Patent: September 30, 2008Assignees: Thales, Le Centre National de la Recherche Scientifique, Ecole Polytechnique, Ecole Nationale Superieure des Techniques AvanceesInventors: Olivier Albert, Jean Etchepare, Aurélie Jullien, Gilles Cheriaux, Nikolay Minkovski, Solomon Saltiel
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Patent number: 7371482Abstract: Methods of manufacture and use of phosphates of transition metals are described as positive electrodes for secondary lithium batteries, including a process for the production of LiMPO4 with controlled size and morphology, M being FexCoyNizMnw, where 0?x?1,0?y?1, 0?w?1, and x+y+z+w=1. According to an exemplary embodiment, a process is described for the manufacture of LiFePO4 including the steps of providing an equimolar aqueous solution of Li1+, Fe3+ and PO43?, evaporating water from the solution to produce a solid mixture, decomposing the solid mixture at a temperature of below 500° C. to form a pure homogeneous Li and Fe phosphate precursor, and annealing the precursor at a temperature of less than 800° C. in a reducing atmosphere to produce the LiFePO4 powder. The obtained powders can have a particle size of less than 1 ?m, and can provide superior electrochemical performance when mixed for an appropriate time with an electrically conductive powder.Type: GrantFiled: November 21, 2003Date of Patent: May 13, 2008Assignees: Le Centre National de la Recherche Scientifique, UmicoreInventors: Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
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Publication number: 20070208061Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).Type: ApplicationFiled: August 11, 2006Publication date: September 6, 2007Applicants: ZENTARIS GmbH, Le Centre National De La Recherche ScientifiqueInventors: Daniel PERRISSOUD, Jean MARTINEZ, Aline MOULIN, Jean-Alain FEHRENTZ, Damien BOEGLIN, Luc DEMANGE
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Publication number: 20070037857Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).Type: ApplicationFiled: August 11, 2006Publication date: February 15, 2007Applicants: ZENTARIS GmbH, Le Centre National De La Recherche Scientifique, University of Montpellier I, University of Montpellier IIInventors: Daniel Perrissoud, Jean Martinez, Aline Moulin, Jean-Alain Fehrentz, Damien Boeglin, Luc Demange
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Publication number: 20060170858Abstract: The invention relates to a non-linear optical filter capable of transmitting an electromagnetic pulse with a duration of less than about 1 picosecond, provided with means for generating an electromagnetic field E with a linear polarization from this pulse, and with a crystal C1 of cubic geometry capable of generating an electromagnetic field E?1 from E with a linear polarization orthogonal to that of E. It comprises means for generating at least one other electromagnetic field E?2 capable of producing constructive interferences with the electromagnetic field E?1.Type: ApplicationFiled: November 30, 2005Publication date: August 3, 2006Applicants: THALES, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE POLYTECHNIQUE, ECOLE NATIONALE SUPERIEURE DES TECHNIQUES AVANCEESInventors: Olivier Albert, Jean Etchepare, Aurelie Jullien, Gilles Cheriaux, Nikolay Minkovski, Solomon Saltiel
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Patent number: 6852507Abstract: Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.Type: GrantFiled: November 21, 1997Date of Patent: February 8, 2005Assignees: Le Centre National de la Recherche ScientifiqueInventors: Martine Cerutti, Hassan Chaabihi, Gerard Devauchelle, Laurent Gauthier, Michel Kaczorek, Marie-Paule LeFranc, Marie-Alix Poul
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Patent number: 6803229Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: GrantFiled: March 25, 2003Date of Patent: October 12, 2004Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche ScientifiqueInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Patent number: 6562577Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: GrantFiled: January 16, 2002Date of Patent: May 13, 2003Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche ScientifiqueInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Patent number: 6355436Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: GrantFiled: September 12, 2000Date of Patent: March 12, 2002Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche ScientifiqueInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Patent number: 5972952Abstract: The invention relates to pharmaceutical compositions for neuroprotection containing the compound (1S,2R) 1-[1-(2-thienyl)-2-alkylcyclohexyl]piperidine or (1S,2R) 1-[1-(2-furanyl)-2-alkylcyclohexyl]piperdine, or their pharmaceutically acceptable salts. The synthesis and method separation of racemic mixtures to provide pure enantiomers is presented. The compositions have use in the treatment of stroke, CNS trauma and Alzheimer's disease.Type: GrantFiled: December 10, 1996Date of Patent: October 26, 1999Assignee: Le Centre National De La Recherche ScientifiqueInventors: Jean-Marc Kamenka, Martine Michaud, Marie-Jeanne Drian, Jacques Vignon, Alain Privat
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Patent number: 5338675Abstract: A novel toxin of the genus Hirsutella which is useful in controlling invertebrate pests.Type: GrantFiled: June 23, 1992Date of Patent: August 16, 1994Assignees: University of Florida, l'Institut National de la Recherche Agronomique (INRA), Le Centre National de la Recherche Scientifique (CNRS)Inventors: Clayton W. McCoy, Alain J. Vey, Isabelle M. Mazet
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Patent number: 4899163Abstract: The antenna constituted by a plurality of identical parallel and symmetrical linear sub-networks (a7, a6, . . . a1, a'1, a'2, . . . , a'7). The centres of symmetry (b7, b.notident.b, . . . , b1, b'1, b'2 . . . , b'7) of the sub-networks (a7 to a'7) are aligned on a line (c) perpendicular to their diameter and are fed in phase. Each sub-network is constituted by a plurality of radiating elements in even numbers disposed at regular intervals and which radiate from fields displaced from 180.degree. from one radiating element to the following. The pitch of the sub-network is approximately equal to a wave-length guided on the substrate of the printed circuit. Each radiating element is a conducting square surface the side of which is approximately equal to half the guided wavelength with one corner connected galvanically to the feed line. The direction of the surfaces change from one element to the following element.Type: GrantFiled: August 9, 1988Date of Patent: February 6, 1990Assignee: Le Centre Regional D'Innovation et de Transfert de Technologie de Bretagne Loi Le Centre National de la Recherche Scientifique, Etablissement Public National a Caractere Scientifique et TechnologiquInventors: Jean-Pierre L. M. Daniel, Phillipe Dupuis, Jean-Luc Alanic