Abstract: A tamper-evident seal comprising: a first seal member having an adhesive surface region; a second seal member having a sealing surface region located for adhesion to the adhesive surface region; at least one of the adhesive surface region and the sealing surface region being at least partially coated with a heat-sensitive layer so that when the adhesive surface region is adhered to the sealing surface region the heat-sensitive layer is sealed between the first seal member and the second seal member for providing evidence of thermal tampering.