Abstract: The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.
Type:
Grant
Filed:
March 6, 1985
Date of Patent:
June 17, 1986
Assignee:
Lee BioMolecular Research Laboratories, Inc.
Abstract: The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.
Type:
Grant
Filed:
June 9, 1981
Date of Patent:
February 4, 1986
Assignee:
Lee BioMolecular Research Laboratories, Inc.