Patents Assigned to Leibniz - Institut fuer Analytische Wissenschaften ISAS - e. V.
  • Patent number: 11043368
    Abstract: A method for ionizing gaseous samples by dielectric barrier discharge and for subsequently analyzing the produced sample ions in an analysis appliance, in particular a mass spectrometer or an ion mobility spectrometer, produces the sample ions by a plasma caused by a dielectric barrier discharge, wherein the dielectric barrier discharge is produced by virtue of a plasma gas being supplied through a capillary made of a dielectric material, wherein a wire-shaped electrode is arranged within the capillary, the electrode being connected to an AC voltage source, wherein the gaseous sample is supplied to the exit region of the capillary, wherein the wire-shaped electrode is connected to the AC voltage source on the high-voltage side.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: June 22, 2021
    Assignee: Leibniz-Institut Für Analytische Wissenschaften-ISAS-e.V.
    Inventors: Joachim Franzke, Felix David Klute, Sebastian Brandt, Wolfgang Vautz
  • Patent number: 10782256
    Abstract: A method for detection and quantification of individual analytes in liquid analyte mixtures, by means of NMR spectrometry, in which method a sample of the analyte mixture has a high-frequency pulse applied to it in an NMR spectrometer, and the resulting NMR spectrum is evaluated, is to be developed further in such a manner that it allows a precise analysis of liquid analyte mixtures even when using low-field NMR spectrometers. For this purpose, the sample of the analyte mixture is placed into a low-field NMR spectrometer, and at least one high-frequency pulse that excites only one specific analyte is applied to it.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: September 22, 2020
    Assignee: Leibniz-Institut fuer Analytische Wissenschaften-ISAS-e.V.
    Inventors: Ahmad Telfah, Roland Hergenroeder, Joerg Lambert
  • Publication number: 20200227245
    Abstract: A method for ionizing gaseous samples by dielectric barrier discharge and for subsequently analyzing the produced sample ions in an analysis appliance, in particular a mass spectrometer or an ion mobility spectrometer, produces the sample ions by a plasma caused by a dielectric barrier discharge, wherein the dielectric barrier discharge is produced by virtue of a plasma gas being supplied through a capillary made of a dielectric material, wherein a wire-shaped electrode is arranged within the capillary, the electrode being connected to an AC voltage source, wherein the gaseous sample is supplied to the exit region of the capillary, wherein the wire-shaped electrode is connected to the AC voltage source on the high-voltage side.
    Type: Application
    Filed: May 23, 2018
    Publication date: July 16, 2020
    Applicant: Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.
    Inventors: Joachim FRANZKE, Felix David KLUTE, Sebastian BRANDT, Wolfgang VAUTZ
  • Publication number: 20200011816
    Abstract: A method for detection and quantification of individual analytes in liquid analyte mixtures, by means of NMR spectrometry, in which method a sample of the analyte mixture has a high-frequency pulse applied to it in an NMR spectrometer, and the resulting NMR spectrum is evaluated, is to be developed further in such a manner that it allows a precise analysis of liquid analyte mixtures even when using low-field NMR spectrometers. For this purpose, the sample of the analyte mixture is placed into a low-field NMR spectrometer, and at least one high-frequency pulse that excites only one specific analyte is applied to it.
    Type: Application
    Filed: December 4, 2017
    Publication date: January 9, 2020
    Applicant: Leibniz-Institut fuer Analytische Wissenschaften-ISAS-e.V.
    Inventors: Ahmad TELFAH, Roland HERGENROEDER, Joerg LAMBERT
  • Publication number: 20180136221
    Abstract: The invention relates to a method for identifying marker proteins for the purpose of diagnosis and risk stratification of blood coagulation disorders.
    Type: Application
    Filed: May 8, 2016
    Publication date: May 17, 2018
    Applicant: LEIBNIZ-INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN - ISAS - E.V.
    Inventors: Florian BECK, Albert SICKMANN, Rene ZAHEDI
  • Patent number: 9874578
    Abstract: An apparatus for taking a sample from at least one fluid system and for passing the sample to an analytical evaluation system connects the piston rod of the sample-taking piston with a controllable drive. A flushing gas feed opens into a feed line downstream from a three-way valve, via a shut-off valve. The three-way valve, the controllable drive, and the shut-off valve are coupled with one another so that for taking a sample, the three-way valve releases the path of the sampling line to the sample-taking cylinder, the shut-off valve is open, and the controllable drive withdraws the sample-taking piston from the sample-taking cylinder, and, for applying the sample to the evaluation system, the shut-off valve is closed, the three-way valve is switched to release the path from the sample-taking piston to the feed line, and the controllable drive pushes the sample-taking piston completely back into the sample-taking cylinder.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 23, 2018
    Assignee: Leibniz-Institut fuer Analytische Wissenschaften-ISAS-e.V.
    Inventors: Wolfgang Vautz, Peter Roeper, Luzia Seifert
  • Publication number: 20160061819
    Abstract: With a method for measurement of thrombocyte function, a solution is created, by which the sensitivity of individual thrombocytes can be measured with the least possible apparatus effort, with high throughput, by passing a liquid thrombocyte solution, in which the thrombocytes are present in isolated form, into a microfluidic chamber and brought into contact with at least one stimulant, wherein an electrical field directed transverse to the entry direction of the thrombocyte solution is applied to the chamber, and the movement path of the thrombocytes in the electrical field is observed and evaluated, in such a manner that thrombocytes having a movement path directed in the direction toward the minus pole of the electrical field are classified as non-activated thrombocytes, and thrombocytes having a movement path directed in the direction toward the plus pole of the electrical field are classified as activated thrombocytes.
    Type: Application
    Filed: August 26, 2015
    Publication date: March 3, 2016
    Applicant: Leibniz - Institut fuer Analytische Wissenschaften - ISAS - e.V.
    Inventors: Jonathan WEST, Dirk JANASEK, Albert SICKMANN
  • Publication number: 20160025762
    Abstract: An apparatus for taking a sample from at least one fluid system and for passing the sample to an analytical evaluation system connects the piston rod of the sample-taking piston with a controllable drive. A flushing gas feed opens into a feed line downstream from a three-way valve, via a shut-off valve. The three-way valve, the controllable drive, and the shut-off valve are coupled with one another so that for taking a sample, the three-way valve releases the path of the sampling line to the sample-taking cylinder, the shut-off valve is open, and the controllable drive withdraws the sample-taking piston from the sample-taking cylinder, and, for applying the sample to the evaluation system, the shut-off valve is closed, the three-way valve is switched to release the path from the sample-taking piston to the feed line, and the controllable drive pushes the sample-taking piston completely back into the sample-taking cylinder.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 28, 2016
    Applicant: Leibniz - Institut fuer Analytische Wissenschaften- ISAS - e.V.
    Inventors: Wolfgang VAUTZ, Peter ROEPER, Luzia SEIFERT
  • Publication number: 20120065102
    Abstract: A method for the analysis of neurite growth is described, in which a substrate having an array pattern is provided, which has first regions on which neurons and cells similar to neurons can adhere, whereby the first regions are surrounded by second regions, in each instance, on which neurons and cells similar to neurons cannot adhere, whereby neurons or cells similar to neurons adhere only on the first regions of the array, and subsequently, the neurons or cells similar to neurons are exposed to one or multiple or no treatment(s), and during this/these treatment(s) and/or afterwards, the neurite outgrowths from the neurons or cells similar to neurons are analyzed by recognizing and quantifying the connections that are formed between the first regions by means of the neurite outgrowths.
    Type: Application
    Filed: November 17, 2011
    Publication date: March 15, 2012
    Applicants: Forschungsgesellschaft fuer Arbeitsphysiologie und Arbeitsschutz e. V., Leibniz - Institut fuer Analytische Wissenschaften ISAS - e. V.
    Inventors: Jonathan WEST, Jean-Philippe FRIMAT, Julia SISNAISKE, Jan HENGSTLER, Christoph VAN THRIEL