Abstract: An optomechanical inertial reference mirror combines an optomechanical resonator with a reflector that serves as an inertial reference for an atom interferometer. The optomechanical resonator is optically monitored to obtain a first inertial measurement of the reflector that features high bandwidth and high dynamic range. The atom interferometer generates a second inertial measurement of the reflector that features high accuracy and stability. The second inertial measurement corrects for drift of the first inertial measurement, thereby resulting in a single inertial measurement of the reflector having high bandwidth, high dynamic range, excellent long-term stability, and high accuracy. The reflector may be bonded to the resonator, or formed directly onto a test mass of the resonator. With a volume of less than one cubic centimeter, the optomechanical inertial reference mirror is particularly advantageous for portable atomic-based sensors and systems.

Abstract: A method for determining an optimized nucleotide sequence encoding a predetermined amino acid sequence, wherein the nucleotide sequence is optimized for expression in a host cell, and wherein the method comprises the steps of: (a) generating a plurality of candidate nucleotide sequences encoding the predetermined amino acid sequence; (b) obtaining a sequence score based on a scoring function based on a plurality of sequence features that influence protein expression in the host cell using a statistical machine learning algorithm, wherein the plurality of sequence features comprises one or more sequence features selected from the group consisting of protein per time, average elongation rate and accuracy for each of the plurality of candidate nucleotide sequences of step (a); and (c) determining the candidate nucleotide sequence with optimized protein expression in the host cell as the optimized nucleotide sequence.

Abstract: The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1, preferably comprising or consisting of a nucleotide sequence SEQ ID NO: 4-6. The invention further relates to a composition comprising the aptamer, and the use of the aptamer as a medicament or a diagnostic reagent, particularly for use in the detection or diagnosing of a rejection of a renal allograft.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein:—the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein: —the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: Method for encoding of quality values of a data structure, whereby said data structure comprises a set of genomic reads, wherein the method comprises the following steps executable by a data processing system: ascertain the quality values of each read covering a certain index locus, —determine a codebook identifier identifying a specific codebook from a plurality of codebooks for said certain index locus based on the ascertained quality values of said certain index locus, whereby each code-book provides a mapping from a quality value of said quality value alphabet to a corresponding quantized quality value of a quantized quality value alphabet, —quantizing all ascertained quality values at said certain index locus using the specific codebook identified by the codebook identifier at said certain index locus in order to obtain for each quality value at said certain index locus a corresponding quantized quality value, and —encode all determined codebook identifiers using a first entropy encoder and encode all qu

Abstract: The invention relates to a method for operating an ion gate having a first, a second, and a third electrode which are arranged one after the other in an intended drifting direction of ions to be influenced by the ion gate, in such a way that the second electrode is arranged after the first electrode and the third electrode is arranged after the second electrode in the drift direction. The ion gate can be switched between a closed state, in which ions cannot drift through the ion gate in the intended drifting direction, and an open state, in which ions can drift through the ion gate in the intended drifting direction. This is accomplished by applying potentials that alternate over time to one or more of the electrodes. In a switching cycle of the ion gate, which comprises the open state and the closed state of the ion gate, two different closed states of the ion gate are produced. In a first closed state, the ion gate is closed by applying a first potential between the second and third electrodes.

Abstract: The invention relates to an optical sensor system, which is designed to interact with a mobile computer device, which has at least one light source and at least one camera, wherein the sensor system has at least one incoupling interface for coupling light from the light source of the computer device into the sensor system and at least one outcoupling interface for coupling light from the sensor system out to the camera of the computer device, wherein the sensor system has at least one optical light-guiding path, by means of which the outcoupling interface is optically connected to the incoupling interface, wherein at least one sensor designed to modify the light guided by the light-guiding path according to a physical quantity influencing the sensor system from outside is arranged in the light-guiding path, wherein at least one sensor designed to modify the light guided by the light-guiding path according to an influencing quantity influencing the sensor system from outside is arranged in the light-guiding pa

Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.

Abstract: The invention provides a cochlea stimulator for implantation comprising optical fibers of which are coupled to an irradiation source that is controlled by a modulator to generate irradiation specific for a pre-determined range of sound-frequencies. The cochlea stimulator effects a frequency-specific activation of the organ of Corti needed for speech perception especially in noisy environment and more complex sounds. For imparting excitation signals which are generated by modulated pulsed laser irradiation conducted within an optical fiber in order to elicit nervous signals in residual functional organ of Corti sections, the auditory prosthesis preferably contains optical fibers which are dimensioned to terminate in end sections within the cochlea at different sites or sections of the organ of Corti. e.g. having different lengths for locating their end sections at different internal parts of the cochlea.

Abstract: We present a method for predictive compression of time-consistent 3D mesh sequences supporting and exploiting scalability. The applied method decomposes each frame of a mesh sequence in layers, which provides a time-consistent multi-resolution representation. Following the predictive coding paradigm, local temporal and spatial dependencies between layers and frames are exploited for layer-wise compression. Prediction is performed vertex-wise from coarse to fine layers exploiting the motion of already encoded neighboring vertices for prediction of the current vertex location. Consequently, successive layer-wise decoding allows to reconstruct frames with increasing levels of detail.

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.

Abstract: We present a method for predictive compression of time-consistent 3D mesh sequences supporting and exploiting scalability. The applied method decomposes each frame of a mesh sequence in layers, which provides a time-consistent multi-resolution representation. Following the predictive coding paradigm, local temporal and spatial dependencies between layers and frames are exploited for layer-wise compression. Prediction is performed vertex-wise from coarse to fine layers exploiting the motion of already encoded neighboring vertices for prediction of the current vertex location. Consequently, successive layer-wise decoding allows to reconstruct frames with increasing levels of detail.

Abstract: The present invention provides an apparatus for insertion of a flexible implant into a body section of an implant recipient, the apparatus comprising an elongate guiding section having a longitudinal axis and an inner volume for removably receiving the implant, an elongate first receiving member connected at its first end to a first actuator arranged for moving the first receiving member within the guiding section in parallel to the axis of the guiding section, a first control device for controlling the actuation of the first actuator, wherein first receiving member at its second end opposite its first end carries a gripping unit for releasably gripping a proximal end of the implant, a second actuator for controlling the configuration of the implant, and a second control device for controlling the actuation of the second actuator.

Abstract: A method of concealing a packet loss during video decoding is provided. An input stream having a plurality of network abstraction layer units NAL is received. A loss of a network abstraction layer unit in a group of pictures in the input stream is detected. A valid network abstraction layer unit order from the available network abstraction layer units is outputted. The network abstraction layer unit order is received by a video coding layer (VCL) and data is outputted.

Abstract: The present invention provides an apparatus for insertion of a flexible implant into a body section of an implant recipient, the apparatus comprising an elongate guiding section having a longitudinal axis and an inner volume for removably receiving the implant, an elongate first receiving member connected at its first end to a first actuator arranged for moving the first receiving member within the guiding section in parallel to the axis of the guiding section, a first control device for controlling the actuation of the first actuator, wherein first receiving member at its second end opposite its first end carries a gripping unit for releasably gripping a proximal end of the implant, a second actuator for controlling the configuration of the implant, and a second control device for controlling the actuation of the second actuator.

Abstract: Provided are among other things ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives and their use for the treatment of cancer.

Abstract: The present invention provides a laser device wherein one diffraction grating and at least two reflectors are arranged such that two coupled resonators are formed for the light path. This laser device is an arrangement forming a first optical resonator comprising a first and a second reflector including in its light path the diffraction by the grating. The second reflector is arranged perpendicularly to an order of diffraction of the grating. Coupled with the first resonator (A), there is provided a second mirror-reflective resonator between a mirror-reflective surface of the grating and the second reflector. In the case of the grating having an even number of ports, the second resonator needs completion by a third reflector arranged to reflect light from specular reflection by the grating back to the grating. For gratings having an odd number of ports, the second reflector is arranged in parallel to the grating. The laser medium is preferably arranged between the first reflector and the grating.

Abstract: The present invention relates to composite ceramic membranes for use in chemical processes such as the separation of molecules, sometimes referred to as molecular sieving, preferably in combination with chemical conversion of molecules selected from a composition of different molecules, e.g. the selective partial or full oxidation. The composite membrane of the invention offers a combination of molecular sieving and oxygen transport that makes the composite membrane suitable for the selective oxidation of hydrocarbons from a feed comprising a mixture hydrocarbons. The composite membrane of the invention comprises a first layer containing an oxygen transporting material (OTM), e.g. perovskite, and, in association with the first layer, a second layer, containing a molecular sieve layer, e.g. a zeolite.