Patents Assigned to Leica Biosystems Nussloch GmbH
  • Patent number: 11774331
    Abstract: A system having a first automatic machine (1) for processing or investigating biological samples and a second automatic machine (16) for processing or investigating biological samples. The first machine (1) and the second machine (16) are electrically connected to an electrical power grid in order to be supplied with electrical energy as an electrical load. The first machine (1) has a first control apparatus (13) and the second machine (16) has a second control apparatus (19), which detect disruptions in the supply of electrical energy from the power grid and, in the event of a disruption, switch over to a withdrawal of electrical energy from a first energy reservoir (12) or a second energy reservoir (18). The first machine (1) and the second machine (16) are also electrically connected to each other, such that the electrical energy is transferrable from an energy store of one of the automatic machines to the other automatic machine.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: October 3, 2023
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Benjamin Siehl, Markus Sharpe, Markus Wittmann
  • Patent number: 11755860
    Abstract: A printer for printing on histology-laboratory consumable articles (16) includes an optical reading device (13), which reads an image pattern of a histology-laboratory consumable article (16) to be printed on by means of the printing device (4), generates analog or digital image-pattern image signals with regard to the read image pattern and transfers the image-pattern image signals to a control device (8) of the printer, and/or which reads an overprint (18) printed onto a histology-laboratory consumable article (16) by the printing device (4), generates analog or digital overprint image signals with regard to the read overprint (18) and transfers the overprint image signals to a control device (8) of the printer, which control device determines at least one quality parameter with regard to the overprint (18).
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: September 12, 2023
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Karl-Heinz Westerhoff
  • Patent number: 11644392
    Abstract: The invention relates to an arrangement having a specimen plate (1) for freezing on a sample for processing in a microtome, which has an upper side (4) for freezing on the sample and a lower side (5), and having a transparent marking frame (6), having opaque regions forming a marking, which is arranged on the specimen plate (1); and to a method for assigning a sample after freezing onto that specimen plate; and to a method for identifying a sample that is frozen onto that specimen plate (1), the marking frame being arranged on the lower side (5) of the specimen plate (1) or so as to fit around the specimen plate (1).
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: May 9, 2023
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Krishna Kishore Nedunuri
  • Patent number: 11519863
    Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 6, 2022
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
  • Patent number: 11493408
    Abstract: A microtome has a sectioning apparatus that comprises a microtome blade, for sectioning histological samples into thin prepared sections. The microtome is characterized in that an optical reading apparatus is present which reads an optically readable image pattern on the microtome blade, generates analog or digital image signals corresponding to the read image pattern and conveys the image signals to a control apparatus of the microtome.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: November 8, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Dirk Tautenhahn, Karl-Heinrich Westerhoff, Markus Woll
  • Patent number: 11468253
    Abstract: The present invention discloses an information processing apparatus (401) for a tissue processor (402). The tissue processor includes one or more sample baskets (403), a plurality of cassettes are located in each sample basket. The information processing apparatus (401) includes: a scanner, configured to scan a barcode containing information to be inputted to acquire a scan result; a camera, configured to capture at least one image for the plurality of cassettes in each sample basket; and a processor, configured to parse the scan result to acquire the information to be inputted and to process the at least one image to acquire an identification of each cassette. Further, the present invention provides an information processing system and an information processing method for a tissue processor.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: October 11, 2022
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Lingjun Xie, Bao Zhang
  • Patent number: 11467068
    Abstract: A microtome, having a sectioning knife and having a specimen head (5) movable relative to the sectioning knife; having an electric drive system (16) for motorized movement of the specimen head (5); having a sensor (21) for detecting the presence of the specimen head (5) at a reference position (z1); and having a control device (18) for controlling the electric drive system (16) and for processing signals of the sensor (21), the control device (18) being configured to control the electric drive system (16) to move the specimen head (5) and to halt the specimen head (5) in reaction to detection of the presence of the specimen head (5) at the reference position (z1).
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 11, 2022
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventor: Mark-Oliver Heinrich
  • Patent number: 11351555
    Abstract: A holder (40) for holding a stack (10) of coverslips (11) or specimen slides (11) has a bottom (20) having at least one side wall (21a, 21b, 22a, 22b) connected thereto, wherein an inner side of the bottom (20) is embodied for placement of the stack (10) of coverslips (11) or specimen slides (11) and carrying that stack (10), and an outer side of the bottom (20) and/or an outer side of the at least one side wall is configured to receive an identification label, such as an RFID (30), and the holder includes such the identification label, such as an RFID (30).
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: June 7, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: 11333582
    Abstract: The disclosure relates to a microtome having a cutting knife, an object holder mounted on a slide, the slide being movable relative to the cutting knife in a cutting direction and in a thickness defining direction, movement of the slide in the thickness defining direction being performed by a first electric motor controlled by a control unit, movement of the slide in the cutting direction being performed by a second electric motor controlled by the control unit, wherein the control unit is configured to control the movement of the slide in the thickness defining direction and in the cutting direction.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 17, 2022
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Zheguang Fan, Xiaoqi Jiang, Yunchao Yang, Song Jin, Xiang Liang, Jinyu Xu
  • Patent number: 11280709
    Abstract: A coverslipping machine (1) is embodied to be connected to an electrical power grid in order to be supplied with electrical energy as an electrical load; and removes specimen slides (4), having samples present thereon, from a specimen slide magazine (5) and respectively carries out a coverslipping process in which a mounting medium (7) and then a coverslip (8) are applied onto each specimen slide (4); and deposits the coverslipped specimen slides (4) in the specimen slide magazine (5) or in a further specimen slide magazine (55). The coverslipping machine (1) has an electrical energy reservoir (12) and an electronic control apparatus (13).
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 22, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Benjamin Siehl, Markus Sharpe, Markus Wittmann
  • Patent number: 11241220
    Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: February 8, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Jo Fleming, Charles E. Clemens, David Berardelli
  • Patent number: 10481054
    Abstract: The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: November 19, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Florian Böhl, Ralf Eckert, Karin Flieger, Markus Berberich, Hermann Ulbrich, Stella Knorr, Andrew Guy
  • Patent number: D932047
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: September 28, 2021
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventor: Werner Hölbl
  • Patent number: D945010
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: March 1, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: D970038
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 15, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: D970040
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: November 15, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: D987107
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: May 23, 2023
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GmbH
    Inventor: Tobias Trump
  • Patent number: D987108
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: May 23, 2023
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GmbH
    Inventor: Tobias Trump
  • Patent number: D987110
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: May 23, 2023
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GmbH
    Inventor: Tobias Trump
  • Patent number: D987111
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: May 23, 2023
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GmbH
    Inventor: Tobias Trump