Patents Assigned to Leidos, Inc.
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Patent number: 11970696Abstract: An array-based system of assembled DNA for computer data storage is described. An array surface contains immobilized seed DNA initially having with blunt (or blocked) ends with a photocleavable optical linker at a forward end thereof holding the last few base pairs. A light source is light is applied to break the linker, generating a sticky end which allows for hybridization. Data-bearing DNA cassettes are introduced to the array and attach via their sticky ends to the unblock sites on the array surface. The attachment is made permanent via ligase.Type: GrantFiled: August 27, 2020Date of Patent: April 30, 2024Assignee: Leidos, Inc.Inventors: Steven Gerald Haupt, Stephen Alan Chappell
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Patent number: 11967495Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.Type: GrantFiled: December 7, 2021Date of Patent: April 23, 2024Assignee: Leidos, Inc.Inventor: Noah Peter Christian
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Patent number: 11793856Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.Type: GrantFiled: September 9, 2020Date of Patent: October 24, 2023Assignee: Leidos, Inc.Inventors: Gabriel M. Gutierrez, Vinayaka Kotraiah, James Pannucci, Ramses Ayala
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Patent number: 11684921Abstract: The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow. The platform enables the concurrent running of multiple detection assay techniques such as lateral flow immunoassays (LFI), Isothermal molecular assays (i.e., Recombinase Polymerase Amplification, or RPA) and/or paper-based chemical assays (i.e., M8, pH paper) from a single wet or dry sample with minimal sample processing. The PDP reduces soldier overburden by decreasing size weight, and power (SWaP) as well as training time, electronic burden, while providing a flexible, customizable assay platform that can be rapidly produced, assembled, sustained, and when contaminated, easily to dispose of.Type: GrantFiled: August 7, 2020Date of Patent: June 27, 2023Assignees: Leidos, Inc., The United States of America as Represented by the Secretary of the ArmyInventors: Kelley D. Betts, Jennifer W. Sekowski
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Publication number: 20230198633Abstract: Entangled quantum photons augment a classically encrypted data message and the augmented message, classical decryption key and quantum photon augmentation key are transmitted on a single classical transmission line to a receiver. Eavesdroppers, i.e., attacks, are detected in accordance with changes to the quantum photons in the augmented message.Type: ApplicationFiled: December 20, 2022Publication date: June 22, 2023Applicant: Leidos, Inc.Inventors: Allyson O’Brien, Joseph Kovba
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Publication number: 20230183299Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.Type: ApplicationFiled: February 22, 2023Publication date: June 15, 2023Applicant: Leidos, Inc.Inventors: Stephen A. Chappell, Vincent P. Mauro, John Dresios
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Patent number: 11639514Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.Type: GrantFiled: April 10, 2020Date of Patent: May 2, 2023Assignee: Leidos, Inc.Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
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Publication number: 20230131772Abstract: A horizontal acoustic vector sensor system described herein includes a housing which has a gimbal assembly therein which is attached to a sensor assembly which has multiple pairs of seismometers that arranged orthogonally to one or more neighboring pairs of seismometers, along an approximately horizontal axis. The gimbal assembly with sensor assembly are enclosed within the housing by an endcap which includes an electronics assembly. The multiple pairs of seismometers are wired to the electronics assembly through a slip-ring which allows for movement of the gimbal assembly without entangling the wires. The horizontal acoustic vector sensor system further includes at least one omni-directional hydrophone integrated into the endcap.Type: ApplicationFiled: December 2, 2022Publication date: April 27, 2023Applicant: Leidos, Inc.Inventors: Norman Gholson, David C. Blain
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Publication number: 20230114388Abstract: An Activation Map Analysis (AMA) system attaches to an existing deep neural network (host network) as an observer that analyzes the internal activities of the host network to provide additional information, e.g., metrics for resilience, interpretability, and adversarial defense, to the end-user. The AMA system is developed using deep k-nearest neighbor (DkNN) coupled with principal component analysis (PCA) for data dimensionality reduction or Hyperdimensional Computing (HDC) to encode activation map data of the host for data reduction.Type: ApplicationFiled: May 26, 2022Publication date: April 13, 2023Applicant: Leidos, Inc.Inventors: Weicheng Shen, Roopa M. Vasan, Victor M. Miranda
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Patent number: 11608363Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.Type: GrantFiled: July 1, 2019Date of Patent: March 21, 2023Assignee: Leidos, IncInventors: Stephen A. Chappell, Vincent P. Mauro, John Dresios
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Patent number: 11585954Abstract: An acoustic vector sensor (“AVS”) includes one or more sensitive elements arranged in an orthogonal configuration to provide high-sensitivity directional performance. The one more sensitive elements may be seismometers arranged in a pendulum-type configuration. The AVS further includes a hydrophone.Type: GrantFiled: April 13, 2020Date of Patent: February 21, 2023Assignee: Leidos, Inc.Inventors: Brian Hamburg, Norman Gholson
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Patent number: 11578102Abstract: This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and ?-synuclein. These peptides, with their demonstrated activity and short half-life, can be used to activate cellular immunity while significantly reducing the potential for adverse events that is often associated with the antibody-based checkpoint inhibitors. The peptides can be used as stand-alone therapeutics or can be used as immune modulators in combination with other therapies.Type: GrantFiled: July 28, 2021Date of Patent: February 14, 2023Assignee: Leidos, Inc.Inventors: Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecilie D. Browne
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Publication number: 20230010033Abstract: Object detection architectures for detecting and classifying objects in an image are modified to incorporate an extending Rapid Class Augmentation (XRCA) progressive learning algorithm with its defining aspect of memory built into its optimizer which allows joint optimization over both the old and the classes using just the new class data and eliminates the issues associated with catastrophic forgetting.Type: ApplicationFiled: June 14, 2022Publication date: January 12, 2023Applicant: Leidos, Inc.Inventor: Hanna Witzgall
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Publication number: 20220308202Abstract: A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance.Type: ApplicationFiled: January 11, 2022Publication date: September 29, 2022Applicant: Leidos, Inc.Inventor: John R. Kendra
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Patent number: 11407829Abstract: This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and ?-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.Type: GrantFiled: May 21, 2020Date of Patent: August 9, 2022Assignee: Leidos, Inc.Inventors: Gabriel M. Gutierrez, Vinayaka Kotraiah, Timothy W. Phares, James Pannucci, Marc Mansour
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Patent number: 11338040Abstract: This disclosure provides peptide conjugates that are useful for inhibiting the progression of a hyperproliferative disorder, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, enhancing a response to a vaccine, or inhibiting the progression of a synucleinopathy.Type: GrantFiled: June 3, 2021Date of Patent: May 24, 2022Assignee: Leidos, Inc.Inventors: Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecille D. Browne
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Publication number: 20220093376Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.Type: ApplicationFiled: December 7, 2021Publication date: March 24, 2022Applicant: Leidos, Inc.Inventor: Noah Peter Christian
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Patent number: 11249183Abstract: A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance.Type: GrantFiled: September 30, 2020Date of Patent: February 15, 2022Assignee: Leidos, Inc.Inventor: John R. Kendra
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Patent number: 11233565Abstract: Apparatus for detecting pulse optical position modulated signals with high background noise by detection of quantum arrival rate at the detector are described. Pulse signals at the detection limit are characterized by the arrival of clusters of individual photons at an optical receiver. The receiver has embedded shot noise that interferes with the detection of the signal of interest. The apparatus distinguishes the signal of interest by a measurement of the rate of arrival of the photons of the signal of interest from the ambient shot noise rate of the receiver. The apparatus determines the optimal signal detection criteria and calculates the expected bit error rate of the decoded data.Type: GrantFiled: October 6, 2020Date of Patent: January 25, 2022Assignee: Leidos, Inc.Inventors: James Charles Lundberg, Christopher Hochuli Fisher, Mark Edwin Krepel
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Patent number: 11227754Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.Type: GrantFiled: April 30, 2019Date of Patent: January 18, 2022Assignee: Leidos, Inc.Inventor: Noah Peter Christian