Patents Assigned to Li-Cor, Inc.
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Patent number: 10988687Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.Type: GrantFiled: November 29, 2017Date of Patent: April 27, 2021Assignee: LI-COR, INC.Inventors: Xinshe Xu, Rose Skopp, Mark Cradduck, Nisha Padhye
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Patent number: 10948415Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.Type: GrantFiled: August 1, 2019Date of Patent: March 16, 2021Assignee: LI-COR, INC.Inventor: Han-Wei Wang
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Patent number: 10775309Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.Type: GrantFiled: June 28, 2019Date of Patent: September 15, 2020Assignee: LI-COR, INC.Inventors: Han-Wei Wang, Lyle R. Middendorf
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Publication number: 20200276583Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.Type: ApplicationFiled: May 18, 2020Publication date: September 3, 2020Applicant: LI-COR, Inc.Inventors: Michael D. Furtaw, Donald T. Lamb, Lyle R. Middendorf
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Patent number: 10758631Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided. A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.Type: GrantFiled: April 12, 2018Date of Patent: September 1, 2020Assignee: LI-COR, INC.Inventors: Vassil Elitzin, William M. Volcheck, Katie Schaepe, Rahul Patil
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Publication number: 20200264132Abstract: Devices, systems, and methods of using them are disclosed that position an end of a capillary electrophoresis tube within an internal tapered nozzle region of an inkjet print head or other microfluidic pump. The capillary electrophoresis tube can extend through an inlet of the microfluidic pump and leave space for a sheath liquid to enter the pump and mix with separated analytes eluted from the capillary electrophoresis tube. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes.Type: ApplicationFiled: April 28, 2020Publication date: August 20, 2020Applicant: LI-COR, Inc.Inventors: Michael D. Furtaw, Donald T. Lamb
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Patent number: 10737268Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.Type: GrantFiled: August 7, 2017Date of Patent: August 11, 2020Assignee: LI-COR, INC.Inventors: Michael D. Furtaw, Donald T. Lamb, Lyle R. Middendorf
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Publication number: 20200179514Abstract: The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kDa) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as IRDye® 700DX.Type: ApplicationFiled: January 24, 2020Publication date: June 11, 2020Applicant: LI-COR, INC.Inventor: JOY L. KOVAR
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Patent number: 10670560Abstract: Devices, systems, and methods of using them are disclosed that position an end of a capillary electrophoresis tube within an internal tapered nozzle region of an inkjet print head or other microfluidic pump. The capillary electrophoresis tube can extend through an inlet of the microfluidic pump and leave space for a sheath liquid to enter the pump and mix with separated analytes eluted from the capillary electrophoresis tube. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes.Type: GrantFiled: January 31, 2017Date of Patent: June 2, 2020Assignee: LI-COR, INC.Inventors: Michael D. Furtaw, Donald T. Lamb
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Publication number: 20200085976Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: ApplicationFiled: November 18, 2019Publication date: March 19, 2020Applicant: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
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Patent number: 10588972Abstract: The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kDa) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as IRDye® 700DX.Type: GrantFiled: June 2, 2015Date of Patent: March 17, 2020Assignee: LI-COR, INC.Inventor: Joy L. Kovar
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Publication number: 20200078474Abstract: A composition comprising: a polymorphic form of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-ulfonatobutyl)-3H-indol- 1- ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and an acceptable excipient.Type: ApplicationFiled: November 18, 2019Publication date: March 12, 2020Applicant: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin
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Patent number: 10548991Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: GrantFiled: November 23, 2015Date of Patent: February 4, 2020Assignee: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin
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Patent number: 10527492Abstract: Systems and methods for controlling optical feedback in an optical system having a radiation source optically coupled via mode matching optics with a resonant optical cavity. The cavity includes at least two cavity mirrors, one of which is a cavity coupling mirror, and has a plurality of optical resonance cavity modes, wherein the radiation source emits a beam of continuous wave radiation and is capable of being scanned whereby a mean optical frequency of the continuous wave radiation beam is adjustable over a range of frequencies, wherein the radiation source is responsive to optical feedback radiation emerging from the cavity, and wherein the mode matching optics couples the beam of continuous wave radiation to the cavity via the cavity coupling mirror. The radiation source and the mode matching optics are aligned so that a mode fill ratio is reduced relative to a maximum mode fill ratio, wherein for the maximum mode-fill ratio the laser beam is coupled with a fundamental cavity mode.Type: GrantFiled: May 16, 2017Date of Patent: January 7, 2020Assignee: LI-COR, Inc.Inventor: Ahmed Bouzid
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Patent number: 10521657Abstract: Systems and methods for detecting, decoupling and quantifying unresolved signals in trace signal data in the presence of noise with no prior knowledge of the signal characteristics (e.g., signal peak location, intensity and width) of the unresolved signals. The systems and methods are useful for analyzing any trace data signals having one or multiple constituent signals, including overlapping constituent signals, and particularly useful for analyzing data signals which often contain an unknown number of constituent signals with varying signal characteristics, such as peak location, peak intensity and peak width, and varying resolutions and varying amounts of asymmetry. A general signal model function is assumed for each unknown, constituent signal in the trace signal data.Type: GrantFiled: November 2, 2018Date of Patent: December 31, 2019Assignee: LI-COR, Inc.Inventor: Patrick G. Humphrey
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Multiple laser optical feedback assisted cavity enhanced absorption spectroscopy systems and methods
Patent number: 10514299Abstract: Systems and methods for detecting trace gases utilize a resonance optical cavity and one, two or more coherent light sources coupled to the cavity through one or more cavity coupling mirrors, whereby two or more optical cavities may share the same gas volume.Type: GrantFiled: August 22, 2018Date of Patent: December 24, 2019Assignee: LI-COR, Inc.Inventor: Serguei Koulikov -
Patent number: 10489964Abstract: Methods and devices are disclosed for the imaging of a biological sample from all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample is positioned on an imaging stage that is capable of full 360-degree rotation in at least one of two orthogonal axes. Positioned about the stage are imaging modules enabling the recording of a series of images in multiple modalities, including reflected visible light, fluorescence, X-ray, ultrasound, and optical coherence tomography. A computer can use the images to construct three-dimensional models of the sample and to render images of the sample conveying information from one or more imaging channels. The rendered images can be displayed for an operator who can manipulate the images to present additional information or viewing angles of the sample. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.Type: GrantFiled: April 21, 2017Date of Patent: November 26, 2019Assignee: LI-COR, INC.Inventor: Han-Wei Wang
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Patent number: 10488382Abstract: Systems and methods for measuring gas flux are disclosed. One method for calculating gas flux includes: receiving a master clock signal from a global positioning system (GPS) module; transmitting a clock synchronization signal that is based on the master clock signal to a measurement subsystem configured to measure environmental data, wherein the measurement subsystem comprises at least two clocks; receiving the environmental data from the measurement subsystem, wherein the environmental data is associated with the at least two clocks; and calculating gas flux based on the environmental data received from the measurement subsystem.Type: GrantFiled: August 15, 2017Date of Patent: November 26, 2019Assignee: LI-COR, Inc.Inventors: Kevin Ediger, Bradley Alan Riensche
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Publication number: 20190353595Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.Type: ApplicationFiled: August 1, 2019Publication date: November 21, 2019Applicant: LI-COR, Inc.Inventor: Han-Wei Wang
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Publication number: 20190338131Abstract: The present disclosure embodies compounds, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.Type: ApplicationFiled: May 7, 2019Publication date: November 7, 2019Applicant: LI-COR, Inc.Inventors: Silvano Sanchini, Rose Skopp, Vassil Elitzin, Nisha Padhye, Teresa Urlacher