Patents Assigned to Lidds AB
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Patent number: 10611646Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.Type: GrantFiled: June 5, 2019Date of Patent: April 7, 2020Assignee: LIDDS ABInventors: Niklas Axén, Stefan Gruden
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Publication number: 20190345038Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.Type: ApplicationFiled: June 5, 2019Publication date: November 14, 2019Applicant: LIDDS ABInventors: Niklas Axén, Stefan Gruden
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Patent number: 10351437Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.Type: GrantFiled: October 16, 2017Date of Patent: July 16, 2019Assignee: LIDDS ABInventors: Niklas Axén, Stefan Gruden
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Publication number: 20190119122Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.Type: ApplicationFiled: October 16, 2017Publication date: April 25, 2019Applicant: LIDDS ABInventors: Niklas AXÉN, Stefan GRUDEN
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Patent number: 9198884Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.Type: GrantFiled: November 27, 2009Date of Patent: December 1, 2015Assignee: LIDDS ABInventors: Lars Åke Malmsten, Niklas Axén, Hans Lennernäs, Anders Carlsson
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Patent number: 9034359Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.Type: GrantFiled: February 27, 2012Date of Patent: May 19, 2015Assignee: Lidds ABInventors: Hans Lennernäs, Bo Lennernäs, Jonas Hugosson, Niklas Axén
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Patent number: 8999389Abstract: A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.Type: GrantFiled: March 14, 2007Date of Patent: April 7, 2015Assignee: Lidds ABInventors: Hans Lennernäs, Niklas Axén
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Patent number: 8936809Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.Type: GrantFiled: March 31, 2006Date of Patent: January 20, 2015Assignee: Lidds ABInventors: Hans Lennernäs, Bo Lennernäs, Jonas Hugosson, Niklas Axén
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Patent number: 8556495Abstract: An injector device is disclosed, the injector device comprising an elongated mixing container extending along a first axis, and a piston member slidably positioned in the mixing container. The injector device comprises a mixing device comprising a mixing member, an elongated member parallel to the first axis and a handle member. The piston member comprises a piston head and a first locking arm flexibly connected to the piston head, such that the first locking arm in a first position extends substantially parallel to the elongated member and engages with the mixing device in such a way that the piston member moves in a first direction along the first axis with the mixing device. In a second position, the first locking arm may allow the mixing device to move relative to the mixing container independently of the piston member.Type: GrantFiled: September 22, 2009Date of Patent: October 15, 2013Assignee: Lidds ABInventors: Niklas Axén, Hans Lennernäs, Johan Yngve, Lars Åke Malmsten, Gunilla Eketorp, Åke G. Pilbrant
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Patent number: 8124118Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.Type: GrantFiled: October 21, 2004Date of Patent: February 28, 2012Assignee: Lidds ABInventors: Hans Lennernäs, Bo Lennernäs, Jonas Hugosson, Niklas Axén
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Publication number: 20110223214Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.Type: ApplicationFiled: November 27, 2009Publication date: September 15, 2011Applicant: LIDDS ABInventors: Lars Åke Malmsten, Niklas Axén, Hans Lennernäs, Anders Carlsson
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Publication number: 20090118215Abstract: A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.Type: ApplicationFiled: March 14, 2007Publication date: May 7, 2009Applicant: Lidds ABInventors: Hans Lennernas, Niklas Axen
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Publication number: 20090036392Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.Type: ApplicationFiled: October 21, 2004Publication date: February 5, 2009Applicant: LIDDS ABInventors: Hans Lennernas, Bo Lennernas, Jonas Hugosson, Niklas Axen
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Publication number: 20080286205Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.Type: ApplicationFiled: March 31, 2006Publication date: November 20, 2008Applicant: Lidds AbInventors: Hans Lennernas, Bo Lennernas, Jonas Hugosson, Niklas Axen