Patents Assigned to Life Technologies, Inc.
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Patent number: 8021610Abstract: A process reduces the microbial content in land mass by providing molecular iodine in the land mass in a concentration in aqueous material in the land mass of at least 5 or 10 parts per million. The molecular iodine may be added in gaseous or liquid or solid state, and may be formed in situ using available water, added water and/or alcohol in the reaction.Type: GrantFiled: October 11, 2007Date of Patent: September 20, 2011Assignee: BioLargo Life Technologies, Inc.Inventor: Kenneth R. Code
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Patent number: 7943158Abstract: An article and process provides a stable technology that reduces the microbial content by providing molecular iodine to the stabilized reagents when at least two reactants are activated by aqueous and/or alcohol materials.Type: GrantFiled: December 7, 2007Date of Patent: May 17, 2011Assignee: Biolargo Life Technologies, IncInventors: Anthony R. Nelson, Susan T. Oeltjen, Christopher J. Rueb, William A. Hendrickson, Kenneth R. Code
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Publication number: 20110104303Abstract: An article or material is applied to the environment of the body of an animal (including humans) to provide both absorbency and antimicrobial activity. The article or material may comprise a water absorbent material; and a composition that reacts with water to produce molecular iodine. The composition provides a local concentration (in the water) of at least 10 parts per million iodine in water carried by the material (that is actual water supported by the water absorbent material) when the material has 5% by weight of water present in the water absorbent. The material may be a flowable material, or the article may be diaper, sanitary pad, bandage, adhesive pad or wrap for an animal.Type: ApplicationFiled: January 10, 2011Publication date: May 5, 2011Applicant: BIOLARGO LIFE TECHNOLOGIES, INC.Inventor: Kenneth R. Code
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Patent number: 7867510Abstract: An article is applied to the body of an animal (including humans) to provide both absorbency and antimicrobial activity. The article may comprise a water absorbent material; and a composition that reacts with water to produce molecular iodine. The composition provides a local concentration (in the water) of at least 10 parts per million iodine in water carried by the material (that is actual water supported by the water absorbent material) when the material has 5% by weight of water present in the water absorbent. The article may be a diaper, sanitary pad, bandage, bandaid or wrap for an animal.Type: GrantFiled: September 7, 2006Date of Patent: January 11, 2011Assignee: BioLargo Life Technologies, IncInventor: Kenneth R. Code
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Publication number: 20100324573Abstract: Surgical instruments, guides, and methods for closure of fascia and other tissue sites are disclosed. A suture passer guide comprises an elongate body with first and second passages for guiding a suture passer. The long axes of the elongate body, the first passage, and the second passage, preferably lie in three separate parallel planes. A suture passer comprises a housing having a needle tip portion and a first suture grasping surface. An elongate body is located at least partially within the housing and is configured to slide within the housing. The elongate body has a second suture grasping surface at the distal end. The first and second suture grasping surfaces preferably are spaced from the needle tip portion.Type: ApplicationFiled: July 1, 2010Publication date: December 23, 2010Applicant: SYNOVIS LIFE TECHNOLOGIES, INC.Inventors: SOUHAIL TOUBIA, LASZLO GARAMSZEGI, JUAN MANUEL VELEZ
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Publication number: 20100234861Abstract: A staple line buttress material having an adhesive surface, packaged and provided in sterile, ready-to-use form. The material can be used to retrofit surgical staplers to provide an improved staple line, and with improved ease of use.Type: ApplicationFiled: March 22, 2010Publication date: September 16, 2010Applicant: SYNOVIS LIFE TECHNOLOGIES, INC.Inventors: B. Nicholas Oray, Daniel L. Mooradian
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Patent number: 7776060Abstract: A combination medical device comprising a circular stapler instrument (4) and one or more portions of preformed buttress material (16) adapted to be stably positioned upon the staple cartridge (12) and/or anvil (14) components of the stapler (4) prior or at the time of use. Positioned buttress material(s) (16) are delivered to a tissue site where the circular stapler (4) is actuated to connect previously severed tissue portions. An embodiment of the invention allows tissue portions to be joined without the use of sutures. The buttress material (16) is made up of two regions, one of which serves primarily to secure the buttress material (16) to the stapler (4) prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler (4) to form anastomoses, while the remaining material secures and seals the newly connected tissue. Methods of use and preparation of the buttress material (16) are also described.Type: GrantFiled: March 21, 2003Date of Patent: August 17, 2010Assignee: Synovis Life Technologies, Inc.Inventors: Daniel L. Mooradian, B. Nicholas Oray, William F. Kuester
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Patent number: 7192400Abstract: A vascular coupler adapted to be fixed into position upon a blood vessel and there retain and position a matable sensing device. In a preferred embodiment, the vascular coupler is an anastomotic coupler and the sensing device comprises an ultrasonic Doppler probe.Type: GrantFiled: October 24, 2002Date of Patent: March 20, 2007Assignee: Synovis Life Technologies, Inc.Inventors: Michael K. Campbell, William F. Kuester, III, Daniel L. Mooradian
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Patent number: 7144402Abstract: A vascular clamp and a method for temporarily occluding a vessel. The vascular clamp comprises two jaws, two handles, and a pivoting point. A biasing mechanism is positioned between the handles for biasing the handles apart so that a closing force is imparted along the length of the jaws. The pivoting points pivotally connect the jaws together and are also configured to allow one jaw to be lifted relative to the other jaw. The method of temporarily occluding a blood vessel comprises the steps of providing a vascular clamp as described above and positioning the clamp about a blood vessel.Type: GrantFiled: June 16, 2003Date of Patent: December 5, 2006Assignee: Synovis Life Technologies, Inc.Inventor: William Frank Kuester, III
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Patent number: 7144588Abstract: The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.Type: GrantFiled: January 17, 2003Date of Patent: December 5, 2006Assignee: Synovis Life Technologies, Inc.Inventors: B. Nicholas Oray, Daniel Mooradian
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Patent number: 7128748Abstract: A combination medical device comprising a circular stapler instrument and one or more portions of preformed buttress material adapted to be stably positioned upon the staple cartridge and/or anvil components of the stapler prior or at the time of use. Positioned buttress material(s) are delivered to a tissue site where the circular stapler is actuated to connect previously severed tissue portions. The buttress material is retained and provides an improved seal between the joined tissue sections. The buttress material is made up of two regions, one of which serves primarily to secure the buttress material to the stapler prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler to form an anastomoses. Methods of use and preparation of the buttress material are also described.Type: GrantFiled: March 26, 2002Date of Patent: October 31, 2006Assignee: Synovis Life Technologies, Inc.Inventors: Daniel L. Mooradian, B. Nicholas Oray
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Publication number: 20040267162Abstract: An adjustable stylet includes a core wire having a portion surrounded by a compression member preferably comprised of a flat wire spring. Depending upon the configuration, compression or relaxation of the compression member in response to forces at the tip or handle of the stylet results in adjustments to the characteristics of the stylet. In a first embodiment, the stiffness of the stylet is adjustable. In a second embodiment, the length of the stylet is adjustable. In a third embodiment, both the stiffness and the length of the stylet are adjustable.Type: ApplicationFiled: May 10, 2004Publication date: December 30, 2004Applicant: Synovis Life Technologies, Inc.Inventor: Thomas Soukup
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Publication number: 20040254596Abstract: A vascular clamp and a method for temporarily occluding a vessel. The vascular clamp comprises two jaws, two handles, and a pivoting point. A biasing mechanism is positioned between the handles for biasing the handles apart so that a closing force is imparted along the length of the jaws. The pivoting points pivotally connect the jaws together and are also configured to allow one jaw to be lifted relative to the other jaw. The method of temporarily occluding a blood vessel comprises the steps of providing a vascular clamp as described above and positioning the clamp about a blood vessel.Type: ApplicationFiled: June 16, 2003Publication date: December 16, 2004Applicant: Synovis Life Technologies, Inc.Inventor: William Frank Kuester
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Patent number: 6776765Abstract: A steerable stylet for use within a lumen of an intravascular device includes a stylet assembly and a handle. The stylet assembly has a distal end portion and a proximal end portion and includes a stylet wire having a lumen and a core wire positioned within the lumen with the distal end portion secured to the stylet wire proximate the distal end portion of the stylet wire. The handle includes a hand-held housing structure connected to one of the proximal end portion of the stylet wire or the core wire. In one embodiment, an adjustable tensioner is connected to the other of the proximal end portion of the stylet wire or the core wire to adjust a relative tension force applied between the stylet wire and the core wire. A tension limiter is arranged to limit the tension force to a limit force that is less than a breaking stress force of the stylet wire when the stylet wire is positioned within the lumen of the intravascular device.Type: GrantFiled: August 21, 2001Date of Patent: August 17, 2004Assignee: Synovis Life Technologies, Inc.Inventors: Thomas M. Soukup, John D. Wright, William Kuester, Patrick Haley
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Publication number: 20040141956Abstract: The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.Type: ApplicationFiled: January 17, 2003Publication date: July 22, 2004Applicant: Synovis Life Technologies, Inc.Inventors: B. Nicholas Oray, Daniel Mooradian
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Patent number: 6755794Abstract: An adjustable stylet includes a core wire having a portion surrounded by a compression member preferably comprised of a flat wire spring. Depending upon the configuration, compression or relaxation of the compression member in response to forces at the tip or handle of the stylet results in adjustments to the characteristics of the stylet. In a first embodiment, the stiffness of the stylet is adjustable. In a second embodiment, the length of the stylet is adjustable. In a third embodiment, both the stiffness and the length of the stylet are adjustable.Type: GrantFiled: April 25, 2001Date of Patent: June 29, 2004Assignee: Synovis Life Technologies, Inc.Inventor: Thomas Soukup
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Publication number: 20040028664Abstract: The invention relates to a solid medium or matrix for storage of nucleic acid molecules (e.g. RNA and/or DNA), particularly vectors and especially plasmids, comprising a solid matrix preferably having a compound or composition which protects against degradation of nucleic acids incorporated into or absorbed on the matrix. The invention also relates to methods for storage or isolation/purification of nucleic acids using this solid medium, and in situ use of the stored or isolated/purified nucleic acids.Type: ApplicationFiled: June 19, 2003Publication date: February 12, 2004Applicants: Life Technologies, Inc., Whatman, Inc.Inventors: Robert W. Blakesley, Mindy D. Goldsborough
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Patent number: 6652594Abstract: A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material, as well as a method of using such a material for surgical repair.Type: GrantFiled: March 14, 2002Date of Patent: November 25, 2003Assignee: Synovis Life Technologies, Inc.Inventors: Ralph T. Francis, Qing Hong Zhao, Amy DeSmith, B. Nicholas Oray
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Publication number: 20030087762Abstract: The present invention provides compounds and compositions capable of stimulating plant growth, regeneration of plant cells and tissues, and transformation of plant cells and tissues, comprising mono- and multi-substituted auxinic analogues of indole-3-acetic acid (IAA) comprising substituent groups such as halo-, alkyl-, alkoxy-, acyl-, acylamido- and acyloxy-groups. The invention relates to a method of using such mono- and multi-substituted auxinic analogues of IAA to affect growth, regeneration or transformation in monocotyledonous and dicotyledonous plants, as well as in transgenic plant tissues. The invention also contemplates the use of these auxinic IAA analogues in the presence of other plant growth regulators, such as cytokinin, etc., to enhance plant growth.Type: ApplicationFiled: February 6, 2001Publication date: May 8, 2003Applicant: Life Technologies, Inc.Inventors: Jhy-Jhu Lin, Jianqing Lan, Nacyra Assad-Garcia
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Publication number: 20030069173Abstract: The present invention provides compositions useful for transfecting eukaryotic cells comprising nucleic acid complexes with peptides, wherein the peptide is optionally covalently coupled to a nucleic acid-binding group, and cationic lipids or dendrimers as transfection agents. The invention also provides transfection compositions in which a peptide is covalently linked to the transfection agent (lipid, cationic lipid or dendrimer). Inclusion of peptides or modified-peptides in transfection compositions or covalent attachment of peptides to transfection agents results in enhanced transfection efficiency. Methods for the preparation of transfection compositions and methods of using these transfection compositions as intracellular delivery agents and extracellular targeting agents are also disclosed.Type: ApplicationFiled: July 23, 2001Publication date: April 10, 2003Applicant: Life Technologies, Inc.Inventors: Pamela Hawley-Nelson, Jianqing Lan, PoJen Shih, Joel A. Jessee, Kevin P. Schifferli, Gulilat Gebeyehu, Valentina C. Ciccarone, Krista L. Evans