Abstract: Methods of lowering the plasma LDL-C levels in a patient on a stable dose of statin where the patient has an LDL-C level above treatment goal. Methods of decreasing a patient's risk for developing coronary heart disease or having a recurrent cardiovascular event wherein the patient is on a stable dose of statin and the patient has an LDL-C level above treatment goal.

Abstract: Gemcabene, a carboxyalkylether, is effective in the treatment and prevention of pancreatitis in subjects. The compound can be administered in an effective dose as the free acid, a pharmaceutically acceptable salt, or an ester or pro-drug that is hydrolyzed or otherwise metabolized in situ to gemcabene as the free acid or salt thereof.

Abstract: A polymeric membrane suitable for use in electrophoresis formed from a pre-polymer having a plurality of crosslinkable moieties and the crosslinkable moieties being crosslinked with a polyfunctional crosslinking agent.

Abstract: The claims describe methods for isolating functionally active Factor VIII using a membrane-based separation system containing a separation membrane to create a first and second interstitial volume between at least two restriction membranes. One or more stabilizing agents are added to the sample and/or an interstitial volume. A solvent in the first interstitial volume maintains FVIII in a desired charge state. Applying a potential between the first and second interstitial volumes separates FVIII on one side of the separation membrane from unwanted molecules on the other side of the separation membrane. These methods may also be used as a substitute for one or more steps in a conventional purification scheme for the separation of native or recombinant FVIII.

Abstract: This invention is directed to a cassette for electrophoresis gels comprising: first and second planar wall members having inner and outer surfaces, top and bottom edges, and lateral edges wherein the wall members are oriented generally parallel to each other and such that the inner wall of each wall member is proximate to the inner wall of the other wall member; spacing means disposed between the inner walls of the wall members and adapted to provide a space for an electrophoresis gel between the inner walls of the wall members, wherein the cassette has an interior which is defined by the space between the wall members; and locking means adapted to prevent locking engagement of the members unless the inner surfaces of the wall members and are substantially parallel to each other and are separated by a predetermined distance, and when the wall members are in locked engagement, to substantially prevent any movement of the wall members away from such locked engagement.

Abstract: An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is provided. A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also provided. The system and method include use of a set of ion permeable barriers and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or plasma.

Abstract: The apparatus includes a container (20) having a base (22) and sides (32) adapted to receive a plurality of plastic gel cassettes. An inlet port (12) is positioned in the base of the container and in fluid communication with the chamber and a baffle (11) is positioned over the inlet port, such that, in use, when gel forming fluid passes through the inlet port into the chamber, the baffle substantially reduces fluid turbulence and vertical fluid movement in the vicinity of the inlet port during flow of the fluid into the chamber. Pretreatment of the plastic cassette to remove polymerisation inhibitors prior to filling the same with fluid is by exhaustive vacuum treatment, optionally with nitrogen gas purging. This can be achieved conveniently using a vacuum chamber in which one or more plastic cassettes are placed. Optionally the vacuum chamber may be the container in which the cassettes are filled with fluid. No barrier films or chemical scavengers are required.

Abstract: A method for separating components from plasma, the method comprising (I) separating the plasma into a first and second component, the first component comprising an albumin/?-1-antirypsin pool and the second component comprising plasma containing components having a molecular mass greater than albumin; (II) treating the second component to form an immunoglobulins concentrate containing immunoglobulins substantially free from components having a molecular mass less than immunoglobulins; (III) treating the immunoglobulins concentrate to remove components having a molecular mass greater than immunoglobulins; and (IV) separating albumin and ?-1-antitrypsin from the albumin/?-1-antitrypsin pool.