Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.

Abstract: A device for harvesting electrical energy from movement of a prosthetic limb. The device including a generator and a controller. The generator adapted to attach to a prosthetic limb. The generator comprising a magnetic linear motor that is configured to generate electrical energy in response to movement of a portion of the prosthetic limb. The controller is electrically connected to the generator and configured to provide electrical energy to a power supply of the prosthetic limb.

Abstract: The present disclosure relates to an orthotic (or brace) and/or prosthetic ankle joint and associated methods adapted to enable adjustment of a talus section or ankle portion or brace with respect to a tibial section of the orthotic (or brace) and/or prosthetic ankle joint. The talus section or ankle portion of the orthotic (or brace) and/or prosthetic ankle joint is movably coupled to the tibial section with the alignment between the talus section and tibial section being adjustable between various positions by disengagement or engagement of a lock of an adjustment mechanism. As the lock is disengaged, the talus section is enabled to pivot with respect to the tibial section in at least one direction as the user moves along a slope.

Abstract: An evacuation dam apparatus including a frame having a top frame member, a bottom frame member, and two side frame members. A working area formed by the frame, a plurality of ports adjacent the working area, an outlet fluidly coupled with the plurality of ports. A fluid flow from at least a portion of the plurality of ports to the outlet forms a fluid flow path across the working area and at least a portion of the fluid flow path is formed within the frame.

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

Abstract: Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss.

Abstract: Described herein are devices and methods used for providing comfort to an infant, and in particular, to devices and methods for introducing a therapy protocol to an infant in, for example, a neonatal intensive care unit.

Abstract: An evacuation dam apparatus including a frame having a top frame member, a bottom frame member, and two side frame members. A working area formed by the frame, a plurality of ports adjacent the working area, an outlet fluidly coupled with the plurality of ports. A fluid flow from at least a portion of the plurality of ports to the outlet forms a fluid flow path across the working area and at least a portion of the fluid flow path is formed within the frame.

Abstract: Systems and methods for analysis of a whole blood sample from an individual to determine the platelet function and coagulation status of the individual in a substantially automated and efficient matter. Also provided here are systems, reagent kits, and methods for concurrent assessment of platelet function and coagulation as they interact during hemostasis.

Abstract: The disclosure includes embodiments of an apparatus, a device, and methods to transform an infant feeding bottle into an infant gavage feeding apparatus. According to an embodiment, an infant gavage feeding apparatus can include an infant feeding bottle, a gavage milk delivery component, a retaining ring, and a cord component. In another embodiment, an infant milk dual-delivery device to transform an infant feeding bottle to an alternate nipple feeding and gavage feeding apparatus includes a gavage milk delivery component, a retaining ring, and a nipple receiving component. The gavage milk delivery component and the nipple receiving component can be positioned in a branched or a stacked configuration. The device can include a flow closure component and a controller to transition the milk flow for a gavage feeding and nipple feeding. The device can include a funnel to allow milk in the nipple to flow back into the infant feeding bottle.

Abstract: The present disclosure relates to an anatomically aligned prosthetic ankle with a passive assist and associated methods. The prosthetic ankle includes a talus movably coupled to a tibia section by a connector about which the talus is pivotal such so during locomotion by a user of the prosthetic ankle. The passive to assist provides a selected dorsi-flexion force to aid in the push-off or pre-swing phases of gait for the user.

Abstract: Provided here are methods of treating Niemann-Pick disease type C (NPC) in a subject or delaying the onset of NPC in a subject by administering to the subject an immunomodulator, or a modulator of amyloid precursor protein (APP) function, or a combination thereof.

Abstract: An evacuation dam apparatus including a frame having a top frame member, a bottom frame member, and two side frame members. A working area formed by the frame, a plurality of ports adjacent the working area, an outlet fluidly coupled with the plurality of ports. A fluid flow from at least a portion of the plurality of ports to the outlet forms a fluid flow path across the working area and at least a portion of the fluid flow path is formed within the frame.

Abstract: In one aspect, methods of reversing or delaying the progression of Alzheimer's disease in a subject having Alzheimer's disease or delaying the onset of Alzheimer's disease in a subject having mild cognitive impairment are provided. In some embodiments, the method comprises administering to the subject an oxysterol inhibitor.

Abstract: Embodiments provide techniques, including systems and methods, for processing imaging data to identify an installed component. Embodiments include a component identification system that is configured to receive imaging data including an installed component, extract features of the installed component from the imaging data, and search a data store of components for matching reference components that match those features. A relevance score may be determined for each of the reference components based on a similarity between the image and a plurality of reference images in a component model of each of the plurality of reference components. At least one matching reference component may be identified by comparing each relevance score to a threshold relevance score and matching component information may be provided to an end-user for each matching reference component.

Abstract: The disclosure is related to a system and method for operating a traction device to detect blood flow patterns in a subject for managing neuropathy related conditions through intraneural facilitation (INF). According to an embodiment, the INF system and method rely on the traction device for positioning the subject in one or more positions, and a processing device for processing intervening signals obtained by a probe positioned on the subject. The signals received from the probe may be used to determine a two dimensional (2D) plane blood flow pattern. Detected changes in the measured blood flow may be used to determine if further traction device positions are required to ensure that the intervening signals demonstrate normal blood flow patterns with improvements to the neuropathy condition. The 2D flow pattern may calculate at least one of Volume Flow (VF) and Pulsatility Index (PI) for each set of signals received.

Abstract: A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.