Patents Assigned to Los Alamos National Security, LLC
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Patent number: 9902748Abstract: Energetic materials that are photoactive or believed to be photoactive may include a conventional explosive (e.g. PETN, nitroglycerine) derivatized with an energetic UV-absorbing and/or VIS-absorbing chromophore such as 1,2,4,5-tetrazine or 1,3,5-triazine. Absorption of laser light having a suitably chosen wavelength may result in photodissociation, decomposition, and explosive release of energy. These materials may be used as ligands to form complexes. Coordination compounds include such complexes with counterions. Some having the formula M(L)n2+ were synthesized, wherein M is a transition metal and L is a ligand and n is 2 or 3. These may be photoactive upon exposure to a laser light beam having an appropriate wavelength of UV light, near-IR and/or visible light. Photoactive materials also include coordination compounds bearing non-energetic ligands; in this case, the counterion may be an oxidant such as perchlorate.Type: GrantFiled: May 15, 2015Date of Patent: February 27, 2018Assignee: Los Alamos National Security, LLCInventors: David E. Chavez, Susan Kloek Hanson, Robert Jason Scharff, Jacqueline Marie Veauthier, Thomas Winfield Myers
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Patent number: 9887976Abstract: Multi-factor authentication using quantum communication (“QC”) includes stages for enrollment and identification. For example, a user enrolls for multi-factor authentication that uses QC with a trusted authority. The trusted authority transmits device factor information associated with a user device (such as a hash function) and user factor information associated with the user (such as an encrypted version of a user password). The user device receives and stores the device factor information and user factor information. For multi-factor authentication that uses QC, the user device retrieves its stored device factor information and user factor information, then transmits the user factor information to the trusted authority, which also retrieves its stored device factor information.Type: GrantFiled: August 16, 2013Date of Patent: February 6, 2018Assignee: Los Alamos National Security, LLCInventors: Richard John Hughes, Charles Glen Peterson, James T. Thrasher, Jane E. Nordholt, Jon T. Yard, Raymond Thorson Newell, Rolando D. Somma
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Patent number: 9878805Abstract: A “black box” space vehicle solution may allow a payload developer to define the mission space and provide mission hardware within a predetermined volume and with predetermined connectivity. Components such as the power module, radios and boards, attitude determination and control system (ADCS), command and data handling (C&DH), etc. may all be provided as part of a “stock” (i.e., core) space vehicle. The payload provided by the payload developer may be plugged into the space vehicle payload section, tested, and launched without custom development of core space vehicle components by the payload developer. A docking station may facilitate convenient development and testing of the space vehicle while reducing handling thereof.Type: GrantFiled: June 22, 2015Date of Patent: January 30, 2018Assignee: Los Alamos National Security, LLCInventors: Stephen Judd, Nicholas Dallmann, Kevin McCabe, Daniel Seitz
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Patent number: 9869644Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for performing radiography. For example, certain embodiments concern X-ray radiography of spontaneous events. Particular embodiments of the disclosed technology provide continuous high-speed x-ray imaging of spontaneous dynamic events, such as explosions, reaction-front propagation, and even material failure. Further, in certain embodiments, x-ray activation and data collection activation are triggered by the object itself that is under observation (e.g., triggered by a change of state detected by one or more sensors monitoring the object itself).Type: GrantFiled: November 10, 2015Date of Patent: January 16, 2018Assignee: Los Alamos National Security, LLCInventors: Laura Smilowitz, Bryan Henson
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Patent number: 9870168Abstract: A key-value store is provided having one or more key-value storage interfaces. A key-value store on at least one compute node comprises a memory for storing a plurality of key-value pairs; and an abstract storage interface comprising a software interface module that communicates with at least one persistent storage device providing a key-value interface for persistent storage of one or more of the plurality of key-value pairs, wherein the software interface module provides the one or more key-value pairs to the at least one persistent storage device in a key-value format. The abstract storage interface optionally processes one or more batch operations on the plurality of key-value pairs. A distributed embodiment for a partitioned key-value store is also provided.Type: GrantFiled: December 22, 2014Date of Patent: January 16, 2018Assignees: EMC Corporation, Los Alamos National Security, LLCInventors: John M. Bent, Sorin Faibish, Dennis P. J. Ting, Percy Tzelnic, Uday Gupta, Gary Grider, David J. Bonnie
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Patent number: 9862964Abstract: The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine synthetase (GS) are provided. The GPT+GS double-transgenic plants of the invention consistently exhibit enhanced growth characteristics, with T0 generation lines showing an increase in biomass over wild type counterparts of between 50% and 300%. Generations that result from sexual crosses and/or selfing typically perform even better, with some of the double-transgenic plants achieving an astounding four-fold biomass increase over wild type plants.Type: GrantFiled: September 5, 2016Date of Patent: January 9, 2018Assignees: Los Alamos National Security, LLC, University of Maine System Board of TrusteesInventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
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Patent number: 9866379Abstract: Quantum communication transmitters include beacon lasers that transmit a beacon optical signal in a predetermined state of polarization such as one of the states of polarization of a quantum communication basis. Changes in the beacon polarization are detected at a receiver, and a retarder is adjusted so that the states of polarization in a received quantum communication optical signal are matched to basis polarizations. The beacon and QC signals can be at different wavelengths so that the beacon does not interfere with detection and decoding of the QC optical signal.Type: GrantFiled: August 31, 2012Date of Patent: January 9, 2018Assignee: Los Alamos National Security, LLCInventors: Jane Elizabeth Nordholt, Raymond Thorson Newell, Charles Glen Peterson, Richard John Hughes
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Patent number: 9855329Abstract: Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.Type: GrantFiled: September 30, 2014Date of Patent: January 2, 2018Assignees: Los Alamos National Security, LLC, Dana-Farber Cancer Institute, Duke UniversityInventors: Bette T. M. Korber, S. Gnanakaran, Simon Perkins, Joseph Sodroski, Barton Haynes
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Patent number: 9858502Abstract: An approach for land cover classification, seasonal and yearly change detection and monitoring, and identification of changes in man-made features may use a clustering of sparse approximations (CoSA) on sparse representations in learned dictionaries. The learned dictionaries may be derived using efficient convolutional sparse coding to build multispectral or hyperspectral, multiresolution dictionaries that are adapted to regional satellite image data. Sparse image representations of images over the learned dictionaries may be used to perform unsupervised k-means clustering into land cover categories. The clustering process behaves as a classifier in detecting real variability. This approach may combine spectral and spatial textural characteristics to detect geologic, vegetative, hydrologic, and man-made features, as well as changes in these features over time.Type: GrantFiled: April 21, 2016Date of Patent: January 2, 2018Assignee: Los Alamos National Security, LLCInventors: Daniela Moody, Brendt Wohlberg
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Patent number: 9853353Abstract: A space vehicle electromechanical system may employ an architecture that enables convenient and practical testing, reset, and retesting of solar panel and antenna deployment on the ground. A helical antenna winding fixture may facilitate winding and binding of the helical antenna.Type: GrantFiled: June 22, 2015Date of Patent: December 26, 2017Assignee: Los Alamos National Security, LLCInventors: Stephen Judd, Nicholas Dallmann, David Guenther, Donald Enemark, Daniel Seitz, John Martinez, Steven Storms
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Patent number: 9852146Abstract: A cluster file system is provided having a plurality of distributed metadata servers with shared access to one or more shared low latency persistent key-value metadata stores. A metadata server comprises an abstract storage interface comprising a software interface module that communicates with at least one shared persistent key-value metadata store providing a key-value interface for persistent storage of key-value metadata. The software interface module provides the key-value metadata to the at least one shared persistent key-value metadata store in a key-value format. The shared persistent key-value metadata store is accessed by a plurality of metadata servers. A metadata request can be processed by a given metadata server independently of other metadata servers in the cluster file system. A distributed metadata storage environment is also disclosed that comprises a plurality of metadata servers having an abstract storage interface to at least one shared persistent key-value metadata store.Type: GrantFiled: March 20, 2015Date of Patent: December 26, 2017Assignees: EMC IP Holding Company LLC, Los Alamos National Security, LLCInventors: John M. Bent, Sorin Faibish, James M. Pedone, Jr., Percy Tzelnic, Dennis P. J. Ting, Latchesar A. Ionkov, Gary Grider
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Publication number: 20170363616Abstract: Disclosed herein are devices including a substrate, one or more regions of electrically active material, and optionally at least one electrode. Also disclosed herein are devices or systems including a substrate, one or more regions of electrically active material including muscle cells and neuronal cells, and optionally at least one electrode. In some embodiments, the muscle cells and neuronal cells form one or more neuromuscular junctions at defined locations on the electrically active material. Also disclosed are methods of using the devices and systems for analyzing the effect of compounds on neuronal cell, muscle cell and/or neuromuscular junction activity.Type: ApplicationFiled: November 24, 2015Publication date: December 21, 2017Applicant: Los Alamos National Security, LLCInventors: Rashi Iyer, Piyush Bajaj
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Patent number: 9844589Abstract: The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.Type: GrantFiled: August 23, 2011Date of Patent: December 19, 2017Assignees: DUKE UNIVERSITY, THE UNIVERSITY OF ALABAMA BIRMINGHAM RESEARCH FOUNDATION, LOS ALAMOS NATIONAL SECURITY, LLCInventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Patent number: 9844590Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.Type: GrantFiled: May 29, 2015Date of Patent: December 19, 2017Assignees: Duke University, Los Alamos National Security, LLC, Beth Israel Deconess Medical Center, The UAB Research FoundationInventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
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Patent number: 9842664Abstract: A processes for recycling uranium that has been used for the production of molybdenum-99 involves irradiating a solution of uranium suitable for forming fission products including molybdenum-99, conditioning the irradiated solution to one suitable for inducing the formation of crystals of uranyl nitrate hydrates, then forming the crystals and a supernatant and then separating the crystals from the supernatant, thus using the crystals as a source of uranium for recycle. Molybdenum-99 is recovered from the supernatant using an adsorbent such as alumina. Another process involves irradiation of a solid target comprising uranium, forming an acidic solution from the irradiated target suitable for inducing the formation of crystals of uranyl nitrate hydrates, then forming the crystals and a supernatant and then separating the crystals from the supernatant, thus using the crystals as a source of uranium for recycle. Molybdenum-99 is recovered from the supernatant using an adsorbent such as alumina.Type: GrantFiled: September 26, 2013Date of Patent: December 12, 2017Assignee: Los Alamos National Security, LLCInventors: Sean Douglas Reilly, Iain May, Roy Copping, Gregory Edward Dale
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Patent number: 9837564Abstract: Photodiodes and nuclear batteries may utilize actinide oxides, such a uranium oxide. An actinide oxide photodiode may include a first actinide oxide layer and a second actinide oxide layer deposited on the first actinide oxide layer. The first actinide oxide layer may be n-doped or p-doped. The second actinide oxide layer may be p-doped when the first actinide oxide layer is n-doped, and the second actinide oxide layer may be n-doped when the first actinide oxide layer is p-doped. The first actinide oxide layer and the second actinide oxide layer may form a p/n junction therebetween. Photodiodes including actinide oxides are better light absorbers, can be used in thinner films, and are more thermally stable than silicon, germanium, and gallium arsenide.Type: GrantFiled: September 23, 2016Date of Patent: December 5, 2017Assignee: Los Alamos National Security, LLCInventors: Milan Sykora, Igor Usov
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Patent number: 9835428Abstract: The detonation of one or more explosive charges and propellant charges by a detonator in response to a fire control signal from a command and control system comprised of a command center and instrumentation center with a communications link therebetween. The fire control signal is selectively provided to the detonator from the instrumentation center if plural detonation control switches at the command center are in a fire authorization status, and instruments, and one or more interlocks, if included, are in a ready for firing status. The instrumentation and command centers are desirably mobile, such as being respective vehicles.Type: GrantFiled: May 27, 2016Date of Patent: December 5, 2017Assignee: Los Alamos National Security, LLCInventors: Jonathan Lee Mace, Gerald J. Seitz, John A. Echave, Pierre-Yves Le Bas
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Patent number: 9835618Abstract: Provided herein are systems for and methods of capturing, detecting, quantifying, and characterizing target moieties that are characterized by having a lipophilic portion of sufficient size and chemical composition whereby the target moiety inserts (or partitions) into a lipid assembly. Examples of such assays employ synthetic lipid constructs such as supported bilayers which are used to capture target moieties; other example assays exploit the natural absorption of compounds into natural lipid constructs such as HDL or LDL particles or cell membranes to capture target moieties. In specific embodiments, the target moieties are bacterial pathogen associated molecular pattern (PAMP) molecules or compounds not yet identified as PAMP molecules.Type: GrantFiled: June 21, 2012Date of Patent: December 5, 2017Assignee: Los Alamos National Security, LLCInventors: Basil I. Swanson, Harshini Mukundan, Rama Murthy Sakamuri
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Publication number: 20170337997Abstract: Apparatus for radioisotope production includes housing, a plurality of target disks inside the housing and a curved windows positioned convex inward toward the disks. During operation, coolant flows though the housing across the disks and windows while electron beams passes through the window and the disks. The window temperature increases, rising the fastest in the middle of the window where the electron beam hits the window. A flat window would buckle because the center would deform during thermal expansion against the relatively unaffected periphery, but the curved window shape allows the window to endure high thermal and mechanical stress created by a combination of heating from the electron beam(s) and elevated pressure from coolant on the inside of the window. Such a window may be used for applications in which a pressurized coolant acts on only one side of the window.Type: ApplicationFiled: November 17, 2015Publication date: November 23, 2017Applicant: Los Alamos National Security, LLCInventors: Keith A. Woloshun, Eric R. Olivas, Gregory E. Dale
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Patent number: 9825979Abstract: A system, apparatus, computer-readable medium, and computer-implemented method are provided for detecting anomalous behavior in a network. Historical parameters of the network are determined in order to determine normal activity levels. A plurality of paths in the network are enumerated as part of a graph representing the network, where each computing system in the network may be a node in the graph and the sequence of connections between two computing systems may be a directed edge in the graph. A statistical model is applied to the plurality of paths in the graph on a sliding window basis to detect anomalous behavior. Data collected by a Unified Host Collection Agent (“UHCA”) may also be used to detect anomalous behavior.Type: GrantFiled: January 30, 2017Date of Patent: November 21, 2017Assignee: Los Alamos National Security, LLCInventors: Joshua Charles Neil, Michael Edward Fisk, Alexander William Brugh, Curtis Lee Hash, Curtis Byron Storlie, Benjamin Uphoff, Alexander Kent