Patents Assigned to Losan Pharma GmbH
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ACTIVE INGREDIENT CONTAINING STABILISED SOLID MEDICINAL FORMS AND METHODS FOR THE PRODUCTION THEREOF
Publication number: 20220000785Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: ApplicationFiled: September 17, 2021Publication date: January 6, 2022Applicant: Losan Pharma GmbHInventors: Peter GRUBER, Dirk Spickermann -
ACTIVE INGREDIENT CONTAINING STABILISED SOLID MEDICINAL FORMS AND METHODS FOR THE PRODUCTION THEREOF
Publication number: 20200188303Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: ApplicationFiled: February 20, 2020Publication date: June 18, 2020Applicant: Losan Pharma GmbHInventors: Peter GRUBER, Dirk Spickermann -
Active ingredient containing stabilised solid medicinal forms and methods for the production thereof
Patent number: 10603280Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: GrantFiled: December 7, 2018Date of Patent: March 31, 2020Assignee: Losan Pharma GmbHInventors: Peter Gruber, Dirk Spickermann -
ACTIVE INGREDIENT CONTAINING STABILISED SOLID MEDICINAL FORMS AND METHODS FOR THE PRODUCTION THEREOF
Publication number: 20190105273Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: ApplicationFiled: December 7, 2018Publication date: April 11, 2019Applicant: Losan Pharma GmbHInventors: Peter GRUBER, Dirk Spickermann -
Patent number: 10206879Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: GrantFiled: September 15, 2017Date of Patent: February 19, 2019Assignee: Losan Pharma GmbHInventors: Peter Gruber, Dirk Spickermann
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Publication number: 20180000739Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: ApplicationFiled: September 15, 2017Publication date: January 4, 2018Applicant: Losan Pharma GmbHInventors: Peter Gruber, Dirk Spickermann
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Patent number: 9775807Abstract: The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.Type: GrantFiled: September 14, 2007Date of Patent: October 3, 2017Assignee: Losan Pharma GmbHInventors: Peter Gruber, Dirk Spickermann
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Patent number: 9205054Abstract: A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and tribasic sodium and potassium phosphates and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.Type: GrantFiled: March 22, 2006Date of Patent: December 8, 2015Assignee: LOSAN PHARMA GMBHInventors: Peter Gruber, Wolfgang Mohr
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Patent number: 8889184Abstract: The present invention relates to a pharmaceutical composition for direct oral administration which is very easy to swallow especially for young children, comprising at least one pharmaceutically active compound. The pharmaceutical composition is present in the form of one or more particles. The particles comprise a core containing the active ingredient which has been provided with one or more coatings. The pharmaceutical composition is preferably administered in combination with a powder and/or granules which, when applied to the tongue, spontaneously generate additional saliva. With the extra saliva, the coated particles form a soft, smooth, but mechanically stable surface perceived as pleasant in the mouth within seconds so that they may be swallowed easily and practically in the right quantity with the extra saliva formed.Type: GrantFiled: September 7, 2006Date of Patent: November 18, 2014Assignee: Losan Pharma GmbHInventors: Peter Gruber, Peter Kraahs
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Patent number: 8481060Abstract: The present invention relates to a process for producing a solid, coated pharmaceutical composition by a melt coating process. The process is adapted to provide a solid, coated pharmaceutical composition by melt coating, which has a fast release.Type: GrantFiled: December 17, 2009Date of Patent: July 9, 2013Assignee: Losan Pharma GmbHInventors: Peter Kraahs, Stefanie Bold, Lars Fahsel
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Publication number: 20110250244Abstract: The present invention relates to a process for producing a solid, coated pharmaceutical composition by a melt coating process. The process is adapted to provide a solid, coated pharmaceutical composition by melt coating, which has a fast release.Type: ApplicationFiled: December 17, 2009Publication date: October 13, 2011Applicant: Losan Pharma GmbHInventors: Peter Kraahs, Stefanie Bold, Lars Fahsel
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Publication number: 20100172981Abstract: Effervescent ibuprofen formulations, which contain (a) an active ingredient-containing granule which contains a water-soluble ibuprofen salt and a basic excipient, and (b) an effervescent granule which contains an acid component and a carbon dioxide-forming component, and a process for their preparation.Type: ApplicationFiled: August 30, 2007Publication date: July 8, 2010Applicant: Losan Pharma GMBHInventors: Peter Gruber, Hubert Keck
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Publication number: 20100035937Abstract: A process for producing a solubilized non-steroidal anti-inflammatory drug (NSAID) the process comprising the steps of: providing a mixture comprising solid NSAID and a first base which is selected from the group of bases which have a pH of at least 11 as 0.1 molar aqueous solution or dispersion, and reacting the NSAID and the first base in essentially dry state, solubilized NSAID obtainable by this process and pharmaceutical compositions comprising the same.Type: ApplicationFiled: August 30, 2007Publication date: February 11, 2010Applicant: Losan Pharma GMBHInventors: Peter Gruber, Peter Kraahs
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Publication number: 20090175940Abstract: A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and tribasic sodium and potassium phosphates and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.Type: ApplicationFiled: March 22, 2006Publication date: July 9, 2009Applicant: Losan Pharma GMBHInventor: Peter Gruber
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Publication number: 20040247675Abstract: An easy to swallow pharmaceutical composition consists of one or several coated particles with a core which contains an active substance and a coat with one or several layers. The coating layer(s) contain at least one hydratable, pharmaceutically acceptable polymer which in contact with saliva or water forms a coherent, mouldable, viscous mass with a slippery surface which does not adhere to the mucous membranes of the mouth and which prevents the active substance-containing particles from leaving the mass and releasing the active substance in the mouth cavity. The coating layer or the outermost coating layer contains an effective amount of at least one salivation promoting agent. The formation of a mouldable, slippery mass and the taste-masking properties of the coating make the composition suitable in particular for administering highly dosed or bad tasting active substances, and can preferably be swallowed even without any liquid.Type: ApplicationFiled: November 12, 2003Publication date: December 9, 2004Applicant: Losan Pharma GmbHInventor: Peter Gruber
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Patent number: 6709678Abstract: An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance, the particles being combined with one or more gelling or swelling agents capable of forming a viscous medium around the particles in an aqueous carrier as well as being provided with a masking surface layer when dispersed in the aqueous carrier. This serves to mask uneven surfaces on the particles and prevent them from adhering to oral mucosa when the composition is ingested and thus makes it easier to administer large dosages of an active substance. The masking surface layer is preferably provided by an increased viscosity of the viscous medium in the immediate vicinity of the particles relative to the viscosity of the surrounding aqueous carrier. A ready-to-use composition is prepared by mixing the composition with an aqueous carrier substantially immediately prior to administration of the composition.Type: GrantFiled: February 10, 1999Date of Patent: March 23, 2004Assignee: Losan Pharma GmbHInventor: Peter Gruber
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Patent number: 6171617Abstract: In particular, the invention relates to a new, clearly dissolving ibuprofen effervescent formulation and a process for the preparation of this formulation. Ibuprofen or (±)2-(4-isobutylphenyl)-propionic acid has the following structural formula and has been for years a proven, non-steroidal antiphlogistic from the group of phenylpropionic acid derivatives, which shows effectiveness in veterinary experimental inflammation models by inhibiting prostaglandin synthesis.Type: GrantFiled: January 6, 1999Date of Patent: January 9, 2001Assignee: Losan Pharma GmbHInventor: Peter Gruber