Patents Assigned to LTS Lohmann
-
Publication number: 20240151635Abstract: The invention relates to a method and device for testing the adhesion of an adhesive, planar body on a planar substrate, wherein the planar body is applied adhesively on the substrate, the substrate is moistened, and a mechanical force is exerted on the substrate by means of an element in the form of a dumbbell-shaped magnetic stirring rod acting on the side of the substrate facing away from the adhesively applied body, wherein the substrate is repeatedly reversibly deformed at least in parts of the adhesive region of the planar body by means of the exertion of force, and, after a period of time, exertion of the mechanical force is ended, and the remaining adhesion of the planar body is assessed in qualitative and/or quantitative terms.Type: ApplicationFiled: February 25, 2022Publication date: May 9, 2024Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventor: Dieter PAULUKAT
-
Publication number: 20240139098Abstract: The present invention relates to a microneedle system (MNS) for intradermal application in a controlled release of glucagon-like peptide analogues.Type: ApplicationFiled: November 3, 2023Publication date: May 2, 2024Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Andreas HENNING, Heiko SPILGIES
-
Patent number: 11964060Abstract: The invention relates to transparent therapeutic systems (TTS) which contain the active substance nicotine and which further contain at least one acid amide group as a lateral functional group. The TTS can be transparent and for discreet use. The invention also relates to methods for producing these TTS, said TTS being produced by methods using said polymers and being charged with active substance by way of a printing method.Type: GrantFiled: February 26, 2018Date of Patent: April 23, 2024Assignee: LTS Lohmann Therapie-Systeme AGInventors: Thomas Hille, Gabriel Wauer, Petra Botzem, Frank Seibertz
-
Publication number: 20240083078Abstract: provided is a method for manufacturing a mold element for the production of microarrays, including the following steps: (i) providing a planar base element having a first surface and a second surface opposite the first surface, (ii) providing a planar auxiliary element on the second surface, (iii) penetrating the base element from the first surface in order to form mold openings, and (iv) reversibly or non-reversibly entering the auxiliary element when penetrating the base element. Moreover, a mold element for the production of microarrays, including a planar base element having a first surface a second surface opposite the first surface, a planar auxiliary element arranged on the second surface, and several mold openings extending from the surface of the base element through the second surface of the base element.Type: ApplicationFiled: January 13, 2022Publication date: March 14, 2024Applicant: LTS Lohmann Therapie-Systeme AGInventors: Olga Grünwald, Michael Kulik
-
Patent number: 11925711Abstract: Disclosed is a method for marking film-type dosage forms, comprising at least the positioning of a film-type dosage form between two layers of a sealable packaging material, the sectional heat-sealing of the two layers of the sealable packaging material so as to obtain an edge-sealed bag containing the film-type dosage form, and the blind-embossing of the film-type dosage form contained in the edge-sealed bag through at least one of the two layers of packaging material of the edge-sealed bag.Type: GrantFiled: October 28, 2016Date of Patent: March 12, 2024Assignee: LTS Lohmann Therapie-Systems AGInventors: Petra Botzem, Torsten Grunenberg, Thomas Hille, Peter Steinborn
-
Publication number: 20240016757Abstract: The present invention relates to aransdermal therapeutic system for the transdermal administration of a systemically active agent having a self-adhesive layer structure. The transdermal therapeutic system includes (A) a backing layer, and (B) a dried biphasic layer. The dried biphasic layer has (a) an outer phase having a composition comprising 75% to 100% of a polymer or polymer mixture, and (b) an inner phase having a composition that includes at least one active agent. The inner phase forms dispersed deposits in the outer phase, with the dried biphasic layer including (c) from 0.1% to 3.5% of an interface mediator other than silicone oil, with the interface mediator having with a kinematic viscosity of from 10 cSt to 100 000 cSt at 25° C.Type: ApplicationFiled: August 4, 2023Publication date: January 18, 2024Applicant: LTS Lohmann Therapie-Systeme AGInventors: Marco EMGENBROICH, Johannes Josef LEONHARD, Kristina KASSNER, Aurélia LAPPERT
-
Publication number: 20230381116Abstract: The invention relates to systems formed from closed liquid-tight packaging and a preferably dimensionally stable aqueous composition which is sealed therein and which, upon activation, releases a liquid phase essentially composed of water in a time-delayed manner. The invention further relates to methods for manufacturing such systems and the use thereof during the production of self-decomposing transdermal therapeutic systems (TTS).Type: ApplicationFiled: August 9, 2023Publication date: November 30, 2023Applicant: LTS Lohmann Therapie-Systeme AGInventors: Florian HAMMES, René EIFLER
-
Patent number: 11801986Abstract: Provided is a method for producing a sealed-edge pouch with a laminate composite stored therein. In some non-limiting embodiments or aspects the laminate composite is detached from a laminate composite web having a carrier film with substrates which are arranged thereon and are covered by means of a respective cover film. An intermediate body is supplied to the laminate composite web or to the laminate composite or is moulded into the carrier film such that the intermediate body or the intermediate bodies surrounds/surround all of the free surfaces of the substrate at least in regions. The laminate composite and all of the intermediate bodies are introduced between two packaging material webs. The packaging material webs are sealed to each other. Finally, the sealed-edge pouches are separated. A device for producing sealed-edge pouches and a sealed-edge pouch produced according to this method are also provided.Type: GrantFiled: July 21, 2018Date of Patent: October 31, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Klaus Schumann, Rolf Böhm, Torsten Grunenberg, Bernd Grünes, Markus Bee, Anna Schlüter
-
Patent number: 11752114Abstract: The present invention concerns a transdermal therapeutic system, comprising a backing layer, which is not permeable for the active ingredient, and a matrix layer on one side of the backing layer, wherein the matrix layer contains at least one pressure sensitive adhesive and ketamine or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one pressure sensitive adhesive has free hydroxyl groups, as well as its use as medicament, in particular for the treatment of depression and pain.Type: GrantFiled: April 17, 2019Date of Patent: September 12, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Florian Hammes, Tobias Kleudgen, Anja Tomeleri
-
Patent number: 11752110Abstract: Transdermal therapeutic system for the transdermal administration of a systemically active agent comprising a self-adhesive layer structure, comprising A) a backing layer, and B) a dried biphasic layer, the dried biphasic layer having a) an outer phase having a composition comprising 75% to 100% of a polymer or polymer mixture, and b) an inner phase having a composition comprising at least one active agent, wherein the inner phase forms dispersed deposits in the outer phase, and c) 0.1% to 3.5% of an interface mediator with a kinematic viscosity of from 10 cSt to 100 000 cSt at 25° C., and C) optionally an additional skin contact layer.Type: GrantFiled: May 20, 2015Date of Patent: September 12, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Marco Emgenbroich, Johannes Josef Leonhard, Kristina Kassner, Aurélia Lappert
-
Patent number: 11752109Abstract: The invention relates to systems formed from closed liquid-tight packaging and a preferably dimensionally stable aqueous composition which is sealed therein and which, upon activation, releases a liquid phase essentially composed of water in a time-delayed manner. The invention further relates to methods for manufacturing such systems and the use thereof during the production of self-decomposing transdermal therapeutic systems (TTS).Type: GrantFiled: July 17, 2017Date of Patent: September 12, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Florian Hammes, René Eifler
-
Patent number: 11744806Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound. The inventive compositions include a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, a dicarboxylic acid, and water or an aqueous solvent mixture, with the composition being free of monocarboxylic acids. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.Type: GrantFiled: December 13, 2018Date of Patent: September 5, 2023Assignee: LTS Lohmann Theraapie-Systeme AGInventors: Michael Linn, Christoph Schmitz, Hanshermann Franke
-
Publication number: 20230248661Abstract: The present invention relates to transdermal therapeutic systems for the transdermal administration of rotigotine containing a therapeutically effective amount of rotigotine base in a self-adhesive layer structure that includes a backing layer and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase formed from a polymer or a polymer mixture along with an inner phase that includes rotigotine base and a polymer mixture including polyvinylpyrrolidone having a K-Value of at least 80 and at least one further hydrophilic polymer selected from the polymer groups: copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The inner phase forms dispersed deposits in the outer phase. The inventive transdermal therapeutic systems optionally include a skin contact layer.Type: ApplicationFiled: March 24, 2023Publication date: August 10, 2023Applicant: LTS Lohmann Therapie-Systeme AGInventors: Marco EMGENBROICH, Elke KLEIN, Heike KLUTH
-
Publication number: 20230241004Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone polymer.Type: ApplicationFiled: January 11, 2023Publication date: August 3, 2023Applicants: LTS LOHMANN Therapie-Systeme AG, DDP Specialty Electronic Materials US 9, LLCInventors: Marco EMGENBROICH, Eva-Marie PRINZ, Elke KLEIN, Heike KLUTH, Xavier THOMAS, Linda Sue NARTKER
-
Publication number: 20230211941Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.Type: ApplicationFiled: March 10, 2023Publication date: July 6, 2023Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: MARC BLOMENKEMPER, MICHAEL LINN, RONALD HACKBARTH, MARKUS BEE
-
Patent number: 11690799Abstract: The present invention relates to a microneedle system (MNS) for the intradermal delivery of interferon, wherein polyvinylpyrrolidone is the major constituent of a completely soluble formulation.Type: GrantFiled: April 23, 2019Date of Patent: July 4, 2023Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Stefan Henke, Andreas Henning, Rolf Pracht, Danny Brodkorb, Sebastian Scherr
-
Patent number: 11648213Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.Type: GrantFiled: June 19, 2019Date of Patent: May 16, 2023Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Patrick Mohr, René Rietscher, René Eifler, Olga Bourquain
-
Patent number: 11633367Abstract: A transdermal therapeutic system containing rotigotine base in a self-adhesive layer structure. The system includes a backing layer, and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase having a composition including 75% to 100% of a polymer or a polymer mixture, and an inner phase that forms dispersed deposits in the outer phase. The inner phase includes rotigotine base and a polymer mixture of at least two hydrophilic polymers. The hydrophilic polymers are selected from the group of polyvinylpyrrolidones having a K-Value of at least 80, polyvinylpyrrolidones having a K-Value of less than 80, copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The polymer mixture in the inner phase is present in an amount sufficient so that it forms a solid solution with the rotigotine base.Type: GrantFiled: May 20, 2015Date of Patent: April 25, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Marco Emgenbroich, Elke Klein, Heike Kluth
-
Patent number: 11634268Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.Type: GrantFiled: January 11, 2021Date of Patent: April 25, 2023Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Marc Blomenkemper, Michael Linn, Ronald Hackbarth, Markus Bee
-
Patent number: 11628141Abstract: The invention relates to a method for producing an active substance laminate, especially an oral active substance laminate (100), having at least one active-substance-containing layer (31), which is arranged on a substrate (20), wherein the method comprises the following steps: a) providing a substrate (20) having an upper side (21) and an underside (22); b) applying an active-substance-containing mass (24) in a gap (25) formed by a first rotating roller (26) and a second rotating roller (27); c) transporting the substrate (20) to the second roller (27) by means of a third rotating roller (28) in such a way that the active-substance-containing mass (24) is applied to the upper side (21) of the substrate (20) by the second roller (27) in the form of an active-substance-containing layer (31); d) transporting an intermediate laminate (30), formed by the substrate (20) and the active-substance-containing layer (31), to a drying device (40); and e) drying the intermediate laminate (30), especially the active-suType: GrantFiled: April 5, 2018Date of Patent: April 18, 2023Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Michael Hoffmann, Elvira Kirstgen, Ralf-lngo Stein, Sandra Wiedersberg, Thomas Stumper