Abstract: The present invention relates to an antimicrobial pigment, its production process, and a cosmetic composition containing the pigment. More particularly, it relates to an antimicrobial cosmetic pigment produced by forming an amorphous glassy inorganic coating layer of metal oxides over the surface of inorganic cosmetic pigment and intercalating antimicrobial metals inside the lattice structure of the coating layer, it's production process, and a cosmetic composition containing it. Silica, either alone or as the principal ingredient in combination with one or more oxides selected from the group consisting of zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, lithium oxide, sodium oxide, potassium oxide, and ferric oxide is utilized as the metal oxide and the composition utilizes silver, copper and zinc as the antimicrobial metals.

Abstract: The present invention relates to a process for continuously preparing unsaturated carboxylic acid esters by esterifying an (aliphatic) alcohol having 1 to 8 carbon atoms with an unsaturated carboxylic acid in the presence of a cation exchange resin catalyst, characterized in that the process is conducted by continuously circulating said reactants in contact with said catalyst from the top to the bottom through a reactor which is composed in the form of a fixed bed divided into 1 to 10 steps wherein each step comprises a catalyst bed, a filter and a air inlet, and has a thermal insulating outer wall, supplying a vaporizing heat for extraction of water, which is produced during the reaction, through a heat exchanger outside the reactor, circulating the reactants between the reactor and the heat exchanger by means of a circulating pump, contacting an azeotropic mixture of water vaporized by the heat exchanger and an alcohol with an alcohol circulating in a column tower or a raw alcohol supplied from an alcohol i

Abstract: The present invention relates to a cephalosporin compound represented by the following general formula (I), its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, which is useful as an antibiotic agent: ##STR1## in which R.sup.1 represents hydrogen or an amino-protecting group,R.sup.2 and R.sup.3 can be identical or different and each represent hydrogen or a hydroxy-protecting group, orR.sup.2 and R.sup.3 together can form a diol-protecting cyclic group,R.sup.4 represents hydrogen or a carboxyl-protecting group,R.sup.5 represents hydrogen, C.sub.1-4 alkyl, alkoxycarbonyl, carboxyl or sulfomethyl,R.sup.6 represents hydrogen, amino or substituted amino, andR.sup.7 represents C.sub.1-4 alkyl, amino or substituted amino, orR.sup.5 and R.sup.6 together with the carbon atoms to which they are attached can form a 3 to 7-membered cyclic group, orR.sup.6 and R.sup.

Abstract: The present invention provides a process for preparing cephem derivatives having the following general formula (I): ##STR1## in which R.sup.1 represents a carboxy group or a protected carboxy group which can form the salt of --COO.sup.- M.sup.+ with an alkali metal ion (M.sup.+) such as sodium, or may represent --COO.sup.- when R.sup.2 has a substituent having positive electric charge such as pyridinium, pyrimidinium or thiazolium,R.sup.2 represents hydrogen, acyloxymethyl, heterocyclic methyl or heterocyclic thiomethyl, each of which can be substituted with appropriate substituents,R.sup.3 represents hydrogen or an amino-protecting group,R.sup.4 represents C.sub.1 -C.sub.4 alkyl or phenyl, or together with the oxygen or phosphorus atom to which it is attached may form a 5- or 6-membered heterocyclic ring, andQ represents N or CH, characterized in that a reactive thiophosphate derivative of thia(dia)zole acetic acid having the following general formula (II): ##STR2## wherein R.sup.3, R.sup.

Abstract: The present invention relates to a cephalosporin compound represented by the following general formula (I): ##STR1## its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, in whichR.sup.1 represents hydrogen or an amino-protecting group,R.sup.2 and R.sup.3 can be identical or different and independently of one another represent hydrogen or a hydroxy-protecting group, orR.sup.2 and R.sup.3 together can form a cyclic diol-protecting group,R.sup.4 represents hydrogen or a carboxyl-protecting group,R.sup.5, R.sup.6 and R.sup.7 independently of one another represent hydrogen, amino or substituted amino, hydroxy, alkoxy, C.sub.1-4 alkyl, carboxyl or alkoxycarbonyl, orR.sup.5 and R.sup.6 together with the carbon atoms to which they are attached can form a C.sub.3-7 cycle, andQ represents CH or N,and to a process for preparation thereof and a pharmaceutical composition containing the compound (I) as an active ingredient.

Abstract: High protein content feed or synthetic steroides are used to elevate the efficiency of feed and promote pig growth. However, the steroids are not metabolized quickly but remain in the body for a long time and may have a detrimental influence on humans. The invention relates to a method for the production of porcine growth hormone which improves the growth of pigs and the efficiency of feed using a synthetic gene in yeast cells. It has been found that porcine growth hormone may be produced economically and in bulk in yeast by gene manipulation technology.

Abstract: The present invention relates to a novel process for preparing sulfonylurea derivatives of formula (I) in a high purity and a high yield characterized in that a sulfonylchloride of formula (V) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII) in the presence of a metal cyanate and an organic base catalyst or a compound of formula (VIII) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII): ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl and R.sup.3 represents hydrogen, methyl, ethyl or phenyl, and to a process for preparing the sulfonylchloride compound of formula (V) above and the compound of formula (VIII) above, both of which are useful as an intermediate compound for preparing the sulfonylurea derivative of formula (I) and to a novel intermediate compound of formula (VIII) as defined above.

Abstract: A parenterally administered, slow releasing bioactive pharmaceutical composition comprises at least one bioactive polypeptide, at least one tocopherol compound, and a release delaying agent.

Abstract: The invention relates to novel herbicidal compounds and compositions. The compounds of the invention are highly substituted derivatives of pyrimidine.

Abstract: The present invention relates to a novel 2-aminothiazolecarboxamide derivative represented by the following general formula (I): ##STR1## in which R.sup.1 -R.sup.5 are defined herein, which is a fungicidal agent useful for controlling phytopathogenic organisms. In addition, the present invention also relates to a process for preparing the novel 2-aminothiazolecarboxamide derivative of formula (I) and use of the compound of formula (I) as an agent for controlling phytopathogenic organisms.

Abstract: The present invention relates to a novel reactive thiophosphate derivative of thia(dia)zole acetic acid which can be very effectively used in the preparation of .beta.-lactam antibiotics, and which is represented by the following general formula (I): ##STR1## in which R.sup.1 represents hydrogen or an amino-protecting group;R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, or --C(R.sup.a)(R.sup.b)CO.sub.2 R.sup.c, wherein R.sup.a and R.sup.b are identical or different from each other and represent hydrogen or C.sub.1 -C.sub.4 alkyl, or R.sup.a and R.sup.b together with a carbon atom to which they are bound can form a C.sub.3 -C.sub.7 cycloalkyl group and R.sup.c is hydrogen or a carboxy-protecting group;R.sup.3 represents C.sub.1 -C.sub.4 alkyl or phenyl or R.sup.3 together with an oxygen atom and a phosphorus atom to which it is bound can form a 5- or 6-membered heterocyclic ring; andQ represents N or CH, and to a process for preparing the same.

Abstract: The present invention relates to 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid iminoester derivative of the general formula I; process of their preparation and a method for their application as herbicides: ##STR1## wherein R and Q are as defined in the specification.

Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.

Abstract: The present invention relates to a novel process for preparing sulfonylurea derivatives of formula (I) in a high purity and a high yield characterized in that a sulfonylchloride of formula (V) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII) in the presence of a metal cyanate and an organic base catalyst or a compound of formula (VIII) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII): ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl and R.sup.3 represents hydrogen, methyl, ethyl or phenyl, and to a process for preparing the sulfonylchloride compound of formula (V) above and the compound of formula (VIII) above, both of which are useful as an intermediate compound for preparing the sulfonylurea derivative of formula (I) and to a novel intermediate compound of formula (VIII) as defined above.

Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.

Abstract: The present invention relates to a process for preparation of 5-pyrazolemercaptan derivatives represented by the following general formula (I), which is useful for synthesis of sulfonylurea-based herbicides, and an intermediate thereof, ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl,R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, or a phenyl group which can contain one or more substituent selected from the group consisting of halogen, nitro and methyl at an optional position, andR.sup.3 represents hydrogen, methyl, ethyl or phenyl.

Abstract: The present invention relates to a process for preparation of 5-pyrazolemercaptan derivatives represented by the following general formula (I), which is useful for synthesis of sulfonylurea-based herbicides, and an intermediate thereof, ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl,R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, or a phenyl group which can contain one or more substituent selected from the group consisting of halogen, nitro and methyl at an optional position, andR.sup.3 represents hydrogen, methyl, ethyl or phenyl.

Abstract: A process for producing a heat-resistant copolymer which comprises the emulsion polymerization of 50 to 75 parts by weight of .alpha.-methylstyrene, 5 parts by weight or less of styrene, 10 to 30 parts by weight of vinyl cyanide compound, 0.1 to 10 parts by weight of ethylenically unsaturated amide, and 10 parts by weight or less of acrylic alkyl ester or methacrylic alkyl ester, in the presense of 1.0 to 30 parts of a seed latex which comprises 50 to 80 parts by weight of .alpha.-methylstyrene, 5 parts by weight or less of styrene, 15 to 30 parts by weight of vinyl cyanide compound, 10 parts by weight or less of ethylenically unsaturated amide and 10 parts by weight or less of acrylic alkyl ester or methacrylic ester.

Abstract: The present invention relates to a process for preparation of 5-pyrazolemercaptan derivatives represented by the following general formula (I), which is useful for synthesis of sulfonylurea-based herbicides, and an intermediate thereof, ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl,R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, or a phenyl group which can contain one or more substituent selected from the group consisting of halogen, nitro and methyl at an optional position, andR.sup.3 represents hydrogen, methyl, ethyl or phenyl.

Abstract: Process for the preparation of hydridocarbonyl tris (triorganophosphorus) rhodium compounds from a concentrated hydroformylation reaction mixture.