Abstract: A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first mode shaping section (13). Furthermore, a method of generating laser pulses (1) using a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12) is described.

Abstract: The invention relates to an impression device and a method for three-dimensional acquisition of intraoral structures as well as a corresponding scanning device. The impression device of the invention comprises an impression sleeve, which has an open and a closed end, and at least one marker which is three-dimensional and disposed on the outside of the impression sleeve.

Abstract: Disclosed herein is a bioreactor for creating and/or conditioning biological tissues, in particular cardiovascular patches. This bioreactor supports additionally cellular differentiation under controlled conditions. The bioreactor comprises a housing having a first section (20) for holding a nutrition solution and/or a cell suspension (24), means (28) for holding a scaffold (34), said means being disposed or disposable inside said bioreactor housing such that said scaffold (34) held therein is exposed to said nutrition solution and/or cell suspension (24) when contained in said first section (20), mechanical stimulation means (54, 68, 86) for applying mechanical stress and/or strain to said scaffold (34) and/or tissue formed thereon when held by said scaffold holding means (28) in said bioreactor housing, and electrical stimulation means (38, 92) for applying an electrical stimulation to said scaffold (34) and/or tissue formed thereon when held by said scaffold holding means (28) in said bioreactor housing.

Abstract: A method of spatially relaying a first radiation component (1) having a first wavelength and a second radiation component (2) having a second wavelength different from the first radiation component (1), using an optical relaying device (10) which comprises a transparent plate (11) having anti-reflection coatings (12, 13) on both side surfaces thereof, comprises transmitting the first radiation component (1) across the optical relaying device (10) with predetermined incident (a) and emergent angles (?), resp., wherein said anti-reflection coatings (12, 13) being effective for the first radiation component (1) at the incident and emergent angles (?, ?), resp., and reflecting the second radiation component (2) at the optical relaying device (10) with a predetermined reflection angle (a) being equal to at least one of said incident and emergent angles (?, ?), wherein the first and second radiation components (1, 2) are split from each other toward different directions or combined into a common beam path.

Abstract: Disclosed herein is a method of examining tissue growth and/or conditioning and/or adhesion properties of cells on a synthetic and/or natural scaffold (30) as well as a perfusion bioreactor (10) for use in this method.

Abstract: A method of generating intra-resonator laser light (1) comprises the steps of coupling input laser light (2), e.g.

Abstract: The invention relates to an impression device and a method for three-dimensional acquisition of intraoral structures as well as a corresponding scanning device. The impression device of the invention comprises an impression sleeve, which has an open and a closed end, and at least one marker which is three-dimensional and disposed on the outside of the impression sleeve.

Abstract: Disclosed herein is a bioreactor (12) for creating and/or conditioning biological tissues and in particular artificial heart valves, vascular grafts and/or cardiovascular patches. The bioreactor (12) comprises a bioreactor housing (30, 32) having a first section (42) and a second section (54), said first section (42) being adapted to receive a nutrition solution, and said second section (54) being adapted to receive said biological tissue, and means (38; 56, 58, 66, 76, 84) for generating and directing a flow of said nutrition solution from said first section (42) to said second section (54) along a first flow path such as to flow along or through at least a portion of said biological tissue, and for directing a back flow of said nutrition solution from said second section (54) to said first section (42) along a second flow path. The flow directing means (56, 58, 66, 76, 84) and said second flow path are contained in said bioreactor housing (30, 32).

Abstract: A Fabry-Pérot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.

Abstract: The present invention relates to an apparatus (1) for automated exploitation of cells from a sample, comprising a plurality of dispensing containers (2) for the separated storage of fluid media, each dispensing container comprising an outlet (21) wherein a media delivery arrangement (3) is associated to each of the dispensing containers (2) and a first valve (22) is connected to each of the outlets (21), a plurality of collecting containers (4) for the collection of fluid media, each collecting container (4) comprising an inlet (41) wherein a second valve (42) is connected to the inlet (41) of each collecting container, and a mounting device (5) for mounting the sample, the mounting device comprising an inlet (51) being connected to the first valve (22), and an outlet (52), wherein the outlet (52) of the mounting device is connected to the second valve (42). Further, the present invention enables a method for automated cell exploitation from a sample by the use of the apparatus (1).

Abstract: In at least one embodiment, a wavelength-tunable light source includes at least one fiber-based partial section and at least one delay section. For a wavelength ? of at least one portion of a radiation emitted by the light source as a function of time t, the relationship ?(t)=?(t??) holds true. In this case, ? is a specific period of time. Furthermore, the delay section includes one or more oligomode fibers.

Abstract: A tunable laser includes an optical gain medium, a first resonator, a periodically tunable optical filter, and a second resonator in which light of a laser wavelength exhibits a round trip time T. The optical filter is arranged between the first resonator and the second resonator and is tuned with a period t. The period t is governed by t=(n/m) T, where n and m are integers and m/n is not an integer.

Abstract: There is provided a microscope device comprising: means for creating a collimated beam of light collected from a sample and comprising at least a first spectral range and a second spectral range, means for separating the collimated beam into a first beam containing a higher percentage of light of the first spectral range than light of the second spectral range and a second beam containing a lower percentage of light of the first spectral range than light of the second spectral range, means for reflecting the first beam, means for reflecting the second beam, means for combining the first beam and the second beam, a detector, and means for imaging the combined first and second beam onto the detector in order to create an image of the sample on the detector, wherein the means for reflecting the first beam and the means for reflecting the second beam are arranged in such a manner that the image created by the first beam and the image created by the second beam are shifted relative to each other on the detector, w

Abstract: The invention relates to an arrangement (10) and a method for detecting an object (18) arranged on a body (14). The arrangement comprises a vibration device (12), which sets the body (14) in a mechanical vibration of predetermined vibration frequency and predetermined vibration phase, an emission device (20) which emits in the direction of the body (14) a coherent electromagnetic detection radiation (26), the radiation frequency of which is selected such that it is reflected at least in part by the body (14) and the object (18) to be detected, a receiver device (30), which receives the radiation (28) reflected by the body (14) and the object (18), and an evaluation device (32) which filters out of the radiation (28) received the portions having the predetermined vibration frequency and evaluates them with respect to their vibration phase difference from the predetermined vibration phase.

Abstract: The present invention refers to a method and reagent kits for determining methylation at cytosine (dC) residues in nucleic acids, such as DNA.

Abstract: A process for detecting nucleic acids, having the following steps: providing at least one nanoparticle that is functionalised for the nucleic acid to be detected by means of at least one oligonucleotide that is bound to it and that is able to hybridize with at least one segment of a nucleic acid to be detected; bringing the functionalised nanoparticle into contact with a sample in which the nucleic acid is to be detected; and measuring a property that provides information about the degree of hybridization of the at least one oligonucleotide with the nucleic acid to be detected. In addition, the process includes the step of exciting the nanoparticles to generate heat, for example by means of a photothermal effect. The invention is suitable, in particular, for high-throughput DNA analysis.

Abstract: The invention relates to an arrangement (10) and a method for detecting an object (18) arranged on a body (14). The arrangement comprises a vibration device (12), which sets the body (14) in a mechanical vibration of predetermined vibration frequency and predetermined vibration phase, an emission device (20) which emits in the direction of the body (14) a coherent electromagnetic detection radiation (26), the radiation frequency of which is selected such that it is reflected at least in part by the body (14) and the object (18) to be detected, a receiver device (30), which receives the radiation (28) reflected by the body (14) and the object (18), and an evaluation device (32) which filters out of the radiation (28) received the portions having the predetermined vibration frequency and evaluates them with respect to their vibration phase difference from the predetermined vibration phase.

Abstract: The invention relates to a method for locating a first mobile terminal within a radio network. Said method comprises the following steps: a first locating process is carried out to determine an initial position of the first terminal; the first locating process is deactivated; a second locating process is carried out to at least approximately determine the current position of the first terminal relative to the initial position; and the first locating process is activated and carried out again to determine a new initial position of the first terminal when the current position reaches a minimum distance from the initial position. The invention also relates to a method for determining cliques of mobile terminals in a radio network encompassing a plurality of mobile terminals.

Abstract: The present invention relates to the use of an IGFBP-2 (insulin-like growth factor binding protein-2) molecule for the production of a pharmaceutical composition for the regulation of senescence processes in cells, tissues and/or organs for the maintenance and control of tissue and/or organ functions and/or for the treatment or alleviation of senescence symptoms or early senescence, wherein the IGFBP-2 molecule is selected from the group of an IGFBP-2 polypeptide or of a functional fragment thereof and of a nucleic acid encoding an IGFBP-2 polypeptide or a functional fragment or derivative thereof. Moreover, corresponding methods of treatment are provided. The use of IGFBP-2 in the preparation of a pharmaceutical composition in the medical intervention of cachexia is described.

Abstract: There is provided a microscope device comprising: means for creating a collimated beam of light collected from a sample and comprising at least a first spectral range and a second spectral range, means for separating the collimated beam into a first beam containing a higher percentage of light of the first spectral range than light of the second spectral range and a second beam containing a lower percentage of light of the first spectral range than light of the second spectral range, means for reflecting the first beam, means for reflecting the second beam, means for combining the first beam and the second beam, a detector, and means for imaging the combined first and second beam onto the detector in order to create an image of the sample on the detector, wherein the means for reflecting the first beam and the means for reflecting the second beam are arranged in such a manner that the image created by the first beam and the image created by the second beam are shifted relative to each other on the detector, w