Patents Assigned to Lupin Inc.
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Publication number: 20230270956Abstract: There is provided a dose counter assembly for use with a medicament dispenser, the dose counter assembly comprising: a) a units dose display means comprising a first count indicia and one or more driver teeth; b) a tens dose display means comprising a second count indicia; and c) a driver, wherein the first count indicia and second count indicia align at a common viewing area to collectively display a count sequence.Type: ApplicationFiled: July 21, 2021Publication date: August 31, 2023Applicant: LUPIN INC.Inventors: Imran SHAIKH, Mukul DALVI, Xian Ming ZENG, Cemeron ALBERG, Tomas MATUSAITIS
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Patent number: 11684607Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).Type: GrantFiled: May 31, 2021Date of Patent: June 27, 2023Assignee: LUPIN, INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
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Patent number: 11602522Abstract: Method of treating sexually transmitted infection in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: May 7, 2021Date of Patent: March 14, 2023Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Patent number: 11478503Abstract: The invention described herein provides new methods and compositions for the cyclical provision of a vitamin B12 compound in a dosing regimen wherein the total amount of vitamin B12 administered during any one treatment cycle does not exceed 35 mcg. More specifically, the invention described in this disclosure promotes the prevention or treatment of a vitamin B12 deficiency, supports the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.Type: GrantFiled: November 18, 2020Date of Patent: October 25, 2022Assignee: Lupin, Inc.Inventors: James A Garegnani, Richard Holl, Gregory Kaufman
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Publication number: 20220259156Abstract: The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.Type: ApplicationFiled: February 25, 2022Publication date: August 18, 2022Applicant: Lupin Inc.Inventors: Richard John Holl, Kurt Nielsen, James Garegnani
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Patent number: 11400093Abstract: New deuterated analogs of elagolix are provided. The novel deuterated elagolix analogs differ from the only previously disclosed deuterated elagolix analogs in structure based on the exclusion of deuterium at certain sites in the compounds and the inclusion of deuterium at other sites. Also provided are new formulations for deuterated elagolix compounds and methods of using such compounds and formulations in the modification of mammalian physiology and especially in the treatment and prevention of a number of diseases and disorders, including endometriosis-associated pain and uterine fibroid conditions.Type: GrantFiled: January 13, 2020Date of Patent: August 2, 2022Assignee: Lupin, Inc.Inventors: James Garegnani, Nicholas Hart, Richard Holl
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Patent number: 11324721Abstract: Embodiments are directed to secnidazole formulations and the use of a secnidazole formulation for the treatment of trichomoniasis in a subject in need thereof.Type: GrantFiled: June 2, 2020Date of Patent: May 10, 2022Assignee: Lupin Inc.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
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Publication number: 20220087978Abstract: Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.Type: ApplicationFiled: September 22, 2020Publication date: March 24, 2022Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL, Gregory KAUFMAN
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Patent number: 11253501Abstract: Embodiments described herein are directed to novel pharmaceutical compositions comprising a plurality of microgranules comprising nitroimidazole compounds, and uses of these pharmaceutical compositions in the treatment of bacterial vaginosis.Type: GrantFiled: June 1, 2016Date of Patent: February 22, 2022Assignee: LUPIN INC.Inventors: David Palling, Ronald S. Vladyka, Joseph Amprey
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Publication number: 20210283106Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).Type: ApplicationFiled: May 31, 2021Publication date: September 16, 2021Applicant: Lupin Inc.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN
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Publication number: 20210260038Abstract: Method of treating a sexually transmitted infection in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: May 7, 2021Publication date: August 26, 2021Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Patent number: 11020377Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).Type: GrantFiled: September 27, 2019Date of Patent: June 1, 2021Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
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Patent number: 11000508Abstract: Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: June 15, 2020Date of Patent: May 11, 2021Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Patent number: 11000507Abstract: Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: March 12, 2020Date of Patent: May 11, 2021Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Publication number: 20210085897Abstract: A medicament dispenser for dispensing medicament comprising: an assembly comprising: at least one peelable medicament carrier carrying multiple distinct medicament portions; a medicament carrier advancing mechanism; a flow channel; and a hinged cover for the flow channel.Type: ApplicationFiled: April 5, 2019Publication date: March 25, 2021Applicant: LUPIN INC.Inventors: Abhishek GUPTA, Imran SHAIKH, Xian-Ming ZENG
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Publication number: 20210015755Abstract: A soft gelatin capsule composition for vaginal administration of secnidazole includes a therapeutically effective amount of secnidazole dispersed in a pharmaceutically acceptable carrier. The therapeutically effective amount of secnidazole is in a range of from about 1 mg to about 500 mg, or in a range of from about 1,000 mg to about 1,500 mg. The composition is used for treating diseases, including bacterial vaginosis or trichomoniasis.Type: ApplicationFiled: July 17, 2019Publication date: January 21, 2021Applicant: Lupin Inc.Inventors: Richard Holl, James Garegnani, Gregory Kaufman
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Patent number: 10857133Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).Type: GrantFiled: September 27, 2019Date of Patent: December 8, 2020Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
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Patent number: 10849884Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).Type: GrantFiled: May 3, 2019Date of Patent: December 1, 2020Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
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Publication number: 20200306228Abstract: Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: June 15, 2020Publication date: October 1, 2020Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Patent number: D984631Type: GrantFiled: July 23, 2020Date of Patent: April 25, 2023Assignee: LUPIN INC.Inventors: Imran Shaikh, Mukul Dalvi, Xian-Ming Zeng, Antonio Belton