Abstract: The present invention provides a computing device including a system ranking unit, a subset ranking unit, an evaluation module of computing units and a decision module. The system ranking unit is configured to rank at least one or more elements to acquire a first ranking based on features of at least one set of data. The subset ranking unit is configured to select a subset from the elements, and is configured to re-rank elements in the subset to acquire a second ranking. The computing units are configured to calculate a relevance of consistency between the first ranking and the second ranking, and are configured to calculate a second rating associated with a first identification message. The decision module is configured to determine a data access level of the first identification message, and configured to access the data based on the data access level.

Abstract: Disclosed herein is an improved pharmaceutical management system and methods implemented by the system for sorting and identifying a medicine via its label and/or package. The method comprises steps of: (1) receiving a plurality of raw images of a package of a medication; (b) juxtaposing two of the plurality of raw images to produce a combined image, in which the two raw images are different from each other; (c) processing the combined image to produce a reference image; and (d) establishing the medication library with the aid of the reference image. The system comprises an image capturing device, an image processor, and a machine learning processor. The image processor is programmed with instructions to execute the method for producing a combined image.

Abstract: Disclosed herein are a method and a system for creating a registered image that integrates the information of CT and CBCT images. With the present method and system, medical practitioners can precisely transform the information of CT image-based treatment plan into the CBCT image so as to accurately control the dosage and location of a radiation therapy. Accordingly, also disclosed herein are methods of treating a cancer in the subject with the aid of the method and/or system of the present disclosure.

Abstract: Disclosed herein is novel use of telbivudine for improving kidney and/or heart function of a subject suffering from a kidney disease, such as acute kidney injury (AKI) or chronic kidney disease (CKD).

Abstract: Disclosed herein are methods of using daphnoretin to treat, prevent or reduce the incidence of organ transplant rejection and graft-versus-host disease (GVHD). According to embodiments of the present disclosure, daphnoretin is administered to the recipient subject or to the donor organ prior to the transplantation to reduce immune response in the recipient subject against the transplanted organ, or to lower the risk of developing GVHD in the recipient subject.

Abstract: Disclosed herein are synthetic peptides and compositions comprising the same, for the treatment and/or prophylaxis of a disease, disorder and/or a condition related to inflammation. Also disclosed herein are methods of treating and/or preventing a disease, disorder and/or a condition related to inflammation, by administering to a subject in need of such treatment a composition containing a therapeutically effective amount of a synthetic peptide of the present disclosure.

Abstract: Disclosed herein are synthetic peptides and compositions comprising the same, for the treatment and/or prophylaxis of a disease or a condition related to angiogenesis. Also disclosed herein are methods of treating and/or preventing a disease or a condition related to angiogenesis, by administering to a subject in need of such treatment a composition containing a therapeutically effective amount of a synthetic peptide of the present disclosure.

Abstract: An expander includes a first handle, a second handle, a first supporting member, and a second supporting member. The first handle includes a first gripping portion, a first pivoting portion, a first connecting portion, and an expanding compass. The second handle includes a second gripping portion, a second pivoting portion, and a second connecting portion. The second gripping portion includes a thru groove, and the expanding compass passes through the thru groove. The second pivoting portion is pivoted to the first pivoting portion. The second connecting portion and the second gripping portion are extending from two ends of the second pivoting portion, and the extension direction of the second connecting portion is not parallel to the extension direction of the second gripping portion.

Abstract: A sensor patch, system, and method for detecting a fluid leaked from a target site of a subject are provided. The sensor patch (100) includes a first detecting unit (127), a second detecting unit (128), and a patch body (110). The first detecting unit (127) includes a first pair of sensors (120A) respectively having a first end (121A) configured to be placed approximating the target site, while the second detecting unit (128) includes a second pair of sensors (120B) respectively having a first end (121B) configured to be placed away from the target site. Each sensor includes a conductive wire (125) and an insulating sheath (126) encapsulating the conductive wire (125) in a manner that a portion of the first end (121A, 121B) of the conductive wire (125) is exposed yet without directly contacting the subject's skin. The patch body (110) has an adhesive surface (104) for securing the first and second detecting units (127, 128) to the subject. The sensor patch enhances the detection specificity.

Abstract: An oral dilator includes a first body, a second body, a rotary member, and a positioning member. The first body includes a housing and a first duckbilled element. The second body includes a second duckbilled element corresponding to the first duckbilled element. The rotary member drives the second body to rotate. The positioning member is on the first body and selectively locks or unlocks the relative position between the first duckbilled element and the second duckbilled element when the second duckbilled element is driven to rotate by the rotary member.

Abstract: Disclosed herein are synthetic peptides and compositions comprising the same for the treatment and/or prophylaxis of an ocular disease, particularly, dry eye disease. Also disclosed herein are methods of treating and/or preventing an ocular disease by administering to a subject in need of such treatment a composition containing a synthetic peptide of the present disclosure.

Abstract: Disclosed herein are novel compounds and uses thereof. The present compounds may suppress the activity of farnesyl transferase and thus, may act as modulators of immune cells; therefor, they are useful for the development of a medicament for treating diseases that are associated with or caused by excessive levels of farnesyl transferase or immune response. Also disclosed herein are pharmaceutical compositions containing the present compounds.

Abstract: Disclosed herein are methods of using daphnoretin to treat, prevent or reduce the incidence of organ transplant rejection and graft-versus-host disease (GVHD). According to embodiments of the present disclosure, daphnoretin is administered to the recipient subject or to the donor organ prior to the transplantation to reduce immune response in the recipient subject against the transplanted organ, or to lower the risk of developing GVHD in the recipient subject.

Abstract: Disclosed herein is a formulation comprising an extracellular vesicle (EV), and a therapeutic active agent induced or embedded in the EV. According to preferred embodiments of the present disclosure, the EV is isolated from umbilical cord mesenchymal stem cells, and the active agent may be a growth factor, an immune-modulating agent, a small molecule, an siRNA, cDNA or a plant ingredient; for example, curcumin. Also disclosed herein are methods for producing the present formulation, and uses of the present formulation in the treatment of various diseases.

Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.

Abstract: A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.

Abstract: Disclosed herein is a novel use of HSD3B1 in disease diagnosis. According to embodiments of the present disclosure, the mRNA or protein level of HSD3B1 may serve as an indicator for diagnosing hepatocellular carcinoma. Also disclosed herein are methods for treating hepatocellular carcinoma by use of HSD3B1 inhibitor.

Abstract: Disclosed herein are synthetic peptides and compositions comprising the same, for the treatment and/or prophylaxis of a disease, disorder and/or a condition related to inflammation. Also disclosed herein are methods of treating and/or preventing a disease, disorder and/or a condition related to inflammation, by administering to a subject in need of such treatment a composition containing a therapeutically effective amount of a synthetic peptide of the present disclosure.

Abstract: A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1 polypeptide to the immune cell suppresses immunoresponse. A method for treating and/or preventing a disease associated with immune hyper-reactivity includes administering the TLT-1 polypeptide to a subject in need thereof.

Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.