Abstract: As a structural modification of the molecule of ranitidine, its 1-(4-methyl-piperazinyl) derivative has been synthesized.The product has shown to be active on the gastric secretion induced by histamine and on gastric and duodenal ulcers.
Abstract: New cysteine derivatives of mucolytic, antipyretic, analgesic and anti-inflammatory action are described, which are obtained by condensing S-(carboxymethyl)-L-cysteine with acetylsalicylic acid. The present invention also relates to salts of the new compounds formed with alkaline and/or alkaline-earth metals, ammonium salts, salts formed with compatible amines, with amino acids or with physiologically acceptable acids. A process is also described for their preparation.
Abstract: New esters of N-(2-amino-3,5-dibromobenzyl)trans-4-aminocyclohexanol, along with certain phenolic derivatives, present interesting expectorant activity, associated with an acute toxicity which is very low. They are, therefore, useful as active principles in pharmaceutical compositions, for oral, topical, injection and rectal use, and are especially indicated for the treatment of bronchial affections.