Abstract: A time-reversal mirroring electromagnetic acoustic treatment system is disclosed where electro-magnetic signals are directed to a region of interest in or on a patient. The EM signals induce an internally sourced acoustic signal due to variations in conductivity of the target tissue. Acoustic data representative of the induced acoustic signal are collected and analyzed to develop a model of a measured conductivity topology representing the conductivity topology of the target tissue. Measured parameters associated with the measured conductivity topology and derived from the acoustic data can be used to generate a time-reversed mirror acoustic treatment signal that can be used to apply a therapeutic treatment to a target tissue within the region of interest.

Abstract: Micro-vesicles that become acoustically sensitive in the presence of a Radio Frequency (RF) Electromagnetic (EM) field are presented. The micro-vesicles can comprise a main body having one or more affinity ligands configured to preferentially bind to a target tissue. Once bound, the micro-vesicles and the target tissue can be bathed in an RF EM field, which induces the target tissue or micro-vesicles to generate an acoustic signal. The micro-vesicles can also become receptive to acoustic energy. An acoustic therapeutic signal can be directed toward the target tissue and micro-vesicles, which causes therapeutic excitation of the micro-vesicles. The therapeutic excitation can include heating the target tissue, releasing a drug formulation, or other excitation. The disclosed techniques can be used with a high degree of precision to activate micro-vesicles local to the target tissue.

Abstract: A medical diagnostic method using systolic and diastolic blood pressures, and pulse frequency of a patient is provided to compute a normalized diastolic distensibility value and a normalized peripheral resistance value, and to automatically compute the product of the normalized diastolic distensibility value and the normalized peripheral resistance value to generate a first product value. The first product value is compared to a stored distribution of normalized diastolic distensibility and a normalized peripheral resistance values for comparable individuals to determine if the first product value is equivalent to a value determined to indicate an abnormal condition. Particular values of the computed parameters aid in determining the etiology of hypertension and direct selection of pharmacotherapy.

Abstract: Ultrasound induced by RF irradiation within FDA exposure limits is produced with sufficient signal-to-noise ratio to allow acquisition of sub-millimeter resolution images within practical time frames.

Abstract: An apparatus having a coil of wire, energized by a repetitively pulsed radio frequency (RF) power source to provide electromagnetic fields to a region within a body. A scanning, directional hydrophone acoustically connected to the body, samples ultrasonic radiation generated by the RF fields at the RF frequency or twice the RF frequency induced from conductive spots. Signals from the hydrophone are analyzed with regard to their time of arrival relative to the RF pulses and with respect to their direction of arrival. These collected data are recorded and displayed as images of the spots within the region.