Patents Assigned to Makhteshim Chemical Works, Ltd.
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Patent number: 9872497Abstract: A pesticidal mixture including (a) spinetoram; and (b) a compound of group A selected from novaluron, pyriproxyfen, tau-fluvalinate, and a combination thereof.Type: GrantFiled: November 5, 2013Date of Patent: January 23, 2018Assignee: MAKHTESHIM CHEMICAL WORKS LTD.Inventors: Assaf Dotan, Tamar Danon
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Patent number: 9730453Abstract: The invention relates to a method for controlling woolly apple aphid insect comprising contacting the insect or a locus, where control of the insect is desired, with a combination of at least one neonicotinoid compound and at least one benzoylphenyl urea compound.Type: GrantFiled: December 16, 2009Date of Patent: August 15, 2017Assignee: MAKHTESHIM CHEMICAL WORKS LTD.Inventor: Avner Barazani
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Publication number: 20150173360Abstract: A method for controlling agricultural insects in a crop, comprising contacting the agricultural insects or the agricultural insects' food supply, habitat, breeding grounds or locus with a synergistically effective amount of a combination of bifenthrin and fipronil is disclosed.Type: ApplicationFiled: March 8, 2012Publication date: June 25, 2015Applicant: MAKHTESHIM CHEMICAL WORKS LTD.Inventor: Assaf Dotan
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Patent number: 8901311Abstract: The present invention relates to a process for preparing heterocyclic fluoroalkenyl sulfones and fluoroalkenyl sulfoxides by allowing the corresponding fluoroalkenyl thioethers to react with a salt of peroxomonosulfuric acid (H2SO5), optionally in the presence of a reaction assistant and optionally in the presence of a diluent.Type: GrantFiled: June 20, 2003Date of Patent: December 2, 2014Assignee: Makhteshim Chemical Works, Ltd.Inventor: Alexander Straub
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Patent number: 8877767Abstract: The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin). Infrared Raman spectra, X-Ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops.Type: GrantFiled: July 31, 2013Date of Patent: November 4, 2014Assignee: Makhteshim Chemical Works Ltd.Inventors: Sharona Zamir, Inna Faktorovitch
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Publication number: 20140259906Abstract: The present invention provides a bead comprising: i) an external zone comprising a super absorbent polymer (SAP) that is capable of absorbing at least about 5 times its weight in water, surrounding ii) at least one internal zone comprising a core that contains at least one agrochemical, wherein the external zone is permeable to oxygen when hydrated, or the internal zone is formulated to release the at least one agrochemical into the external zone over a period of at least about one week when the hydrogel of the external zone is hydrated. The present invention also provides methods of using beads of the invention.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: MAKHTESHIM CHEMICAL WORKS LTD.Inventors: Uri Shani, Asher Vitner, Matti Ben-Moshe, Eran Segal
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Patent number: 8815921Abstract: The invention relates to novel active substance combinations consisting of heterocyclic trifluorobutenylen of formula (I), wherein X is halogen and N is 0, 1 or 2, and of known insecticide substances. Said novel active substance combinations are suitable for fighting harmful pests like insects and nematodes.Type: GrantFiled: April 20, 2004Date of Patent: August 26, 2014Assignee: Makhteshim Chemical Works, Ltd.Inventors: Wolfram Andersch, Anton Kraus, Koichi Ishikawa
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Publication number: 20140213626Abstract: The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoroethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: MAKHTESHIM CHEMICAL WORKS LTD.Inventor: Sharona ZAMIR
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Patent number: 8691862Abstract: The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.Type: GrantFiled: April 27, 2011Date of Patent: April 8, 2014Assignee: Makhteshim Chemical Works Ltd.Inventor: Sharona Zamir
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Patent number: 8648203Abstract: The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-?,?,?-trifluoro-2,6-di-nitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops.Type: GrantFiled: April 11, 2012Date of Patent: February 11, 2014Assignee: Makhteshim Chemical Works Ltd.Inventors: Shlomi Cohen, Sharona Zamir
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Publication number: 20140039026Abstract: The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.Type: ApplicationFiled: May 13, 2013Publication date: February 6, 2014Applicant: MAKHTESHIM CHEMICAL WORKS LTD.Inventor: Sharona ZAMIR
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Publication number: 20130261303Abstract: The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed from the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80° to 1300° C., preferably, 90° to 1000° C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating and purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.Type: ApplicationFiled: May 30, 2013Publication date: October 3, 2013Applicant: MAKHTESHIM CHEMICAL WORKS, LTD.Inventors: David OVADIA, Raya STURKOVICH, David LEONOV
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Patent number: 8546411Abstract: The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate (azoxystrobin). Infrared Raman spectra, X-ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops.Type: GrantFiled: August 7, 2008Date of Patent: October 1, 2013Assignee: Makhteshim Chemical Works Ltd.Inventors: Sharona Zamir, Inna Faktorovitch
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Patent number: 8524723Abstract: The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate (azoxystrobin). Infrared Raman spectra, X-ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs “A” and “B” are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms “A” and “B”, as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs “A” and “B” or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops.Type: GrantFiled: December 6, 2012Date of Patent: September 3, 2013Assignee: Makhteshim Chemical Works Ltd.Inventors: Sharona Zamir, Inna Faktorovitch
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Publication number: 20130225535Abstract: The present invention relates to a composition comprising a combination of a morpholine fungicide; a phthalimide fungicide; and a phosphorus containing fungicide, wherein the composition has a synergistically enhanced activity.Type: ApplicationFiled: August 26, 2010Publication date: August 29, 2013Applicant: MAKHTESHIM CHEMICAL WORKS LTD.Inventors: Noam Sheffer, Daniel Camus
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Publication number: 20130210863Abstract: The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a Benzoylphenyl urea insecticide (preferably novaluron) and to the related compositions and methods of controlling insects.Type: ApplicationFiled: July 31, 2011Publication date: August 15, 2013Applicant: MAKHTESHIM CHEMICAL WORKS, LTD.Inventors: Assaf Dotan, Ganit Levi-Ruso
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Patent number: 8471013Abstract: The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed form the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80° to 1300° C., preferably, 90° to 1000° C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating an purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.Type: GrantFiled: December 16, 2007Date of Patent: June 25, 2013Assignee: Makhteshim Chemical Works, Ltd.Inventors: David Ovadia, Raya Sturkovich, David Leonov
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Patent number: 8440709Abstract: The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.Type: GrantFiled: December 14, 2006Date of Patent: May 14, 2013Assignee: Makhteshim Chemical Works Ltd.Inventor: Sharona Zamir
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Patent number: 8426605Abstract: Disclosed are novel active substance combinations comprising specific heterocyclic trifluorobutenyls and previously known fungicidal agents. Said active substance combinations have a very good synergistic fungicidal, nematicidal, insecticidal, and/or acaricidal effect.Type: GrantFiled: April 20, 2004Date of Patent: April 23, 2013Assignee: Makhteshim Chemical Works, Ltd.Inventors: Wolfram Andersch, Ulrike Wachendorff-Neumann, Anton Kraus
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Publication number: 20120197023Abstract: The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-?,?,?-trifluoro-2,6-di-nitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops.Type: ApplicationFiled: April 11, 2012Publication date: August 2, 2012Applicant: Makhteshim Chemical Works Ltd.Inventors: Shlomi Cohen, Sharona Zamir