Abstract: Spontaneously dispersible concentrates capable of forming ultramicroemulsions are described. The concentrates include esters of formula (I) and (II):
wherein (a) R1, R3, R4, and R5 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene and R2 is glucose:(1,2); (b) R2, R3, R4, and R5 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene and R1 is glucose:(1,3); (c) R2, R3, R4, and R5 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene and R1 is rhamnose:(1,4); or (d) R2, R3, R4, and R5 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene and R1 is rutinose:(1,5);
wherein
(a) R1, R2, and R4 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene and R3 is rhamnose:(11,7); or (b) R2 and R4 each independently represents a C6-22 alkyl, a C6-22 alkenyl or a C6-22 alkapolyene, R1 is methyl, and R3 is rutinose:(11,8).
Abstract: Spontaneously dispersible concentrates comprising new esters of Baccatin-III, 10-Deacetylbaccatin-III and 14-OH-10-Deacetylbaccatin-III, procedures for their production. The preparation of aqueous ultramicroemulsions, their incorporation into pharmaceutical compositions having antitumor, antiviral and virucidal activity, are efficacious in the treatment of eczemae and psoriasis and stimulate the increased absorption of exogenous activators, regulators or modulators, are described.
Abstract: New biotenside esters and phosphatides formed with Vitamin-D and Vitamin-E compounds possessing a pronounced antitumor activity, processes for their production as well as for the preparation of concentrates and pharmaceutical compositions containing these new esters and phosphatides, and their use for treating tumors are described.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
May 13, 1997
Assignee:
Marigen S.A.
Inventors:
Carl Eugster, Conrad Hans Eugster, Walter Haldemann, Giorgio Rivara
Abstract: New biotenside esters, processes for their preparation and their use as solvents and hydrotropic agents (coemulgators) in the preparation of spontaneously dispersible concentrates containing therapeutic or cosmetic agents are described.
Type:
Grant
Filed:
January 11, 1994
Date of Patent:
January 14, 1997
Assignee:
Marigen S.A.
Inventors:
Carl Eugster, Conrad H. Eugster, Walter Haldemann, Giorgio Rivara
Abstract: Methods for treatment of tumours with ultramicroemulsions from spontaneously dispersible concentrates containing xanthophyll esters, and new esters with xanthophyll compounds and processes for their production are provided.
Type:
Grant
Filed:
November 21, 1994
Date of Patent:
July 16, 1996
Assignee:
Marigen S.A.
Inventors:
Carl Eugster, Conrad H. Eugster, Walter Haldemann, Giorgio Rivara
Abstract: New biotenside esters and phosphatides formed with Vitamin-D and Vitamin-E compounds possessing a pronounced antitumor activity, processes for their production as well as for the preparation of concentrates and pharmaceutical compositions containing these new esters and phosphatides, and their use for treating tumors are described.
Type:
Grant
Filed:
September 30, 1994
Date of Patent:
March 26, 1996
Assignee:
Marigen, S.A.
Inventors:
Carl Eugster, Conrad H. Eugster, Walter Haldemann, Giorgio Rivara
Abstract: There are described spontaneously dispersible agents containing sterolester and/or sterolphosphor compounds having a pronounced antitumour activity. Novel sterolesters and sterolphosphor compounds, their use for treating tumors, and processes for their preparation are disclosed.
Type:
Grant
Filed:
August 13, 1992
Date of Patent:
March 5, 1996
Assignee:
Marigen S.A.
Inventors:
Carl Eugster, Conrad H. Eugster, Walter Haldemann, Giorgio Rivara
Abstract: There are described antitumour sterols, their fatty acid esters and glucosides, processes for their preparation, spontaneously dispersible agents containing these sterols, their fatty acid esters and glucosides, and their use for treating tumours.
Type:
Grant
Filed:
February 15, 1991
Date of Patent:
December 14, 1993
Assignee:
Marigen S.A.
Inventors:
Carl Eugster, Conrad Eugster, Walter Haldemann, Giorgio Rivara