Patents Assigned to Martek Biosciences Corporation
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20100024050
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 28, 2010
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7645597
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: January 12, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7645598
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: January 12, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7642074
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: January 5, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7638315
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: December 29, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • OXYLIPINS FROM STEARIDONIC ACID AND GAMMA-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20090320148
    Abstract: Disclosed are novel oxylipins that are derived from ?-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
    Type: Application
    Filed: January 31, 2007
    Publication date: December 24, 2009
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Linda Mary Aaterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Dutt Vinjamoori
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7629450
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: December 8, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7626009
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: December 1, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611874
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611875
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611876
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608702
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608753
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608703
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7605245
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: October 20, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7601522
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: October 13, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • Method for production of arachidonic acid
    Patent number: 7601523
    Abstract: The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: October 13, 2009
    Assignee: Martek Biosciences Corporation
    Inventor: William R. Barclay
  • Schizochytrium Fatty Acid Synthase (FAS) and Products and Methods Related Thereto
    Publication number: 20090229015
    Abstract: Disclosed are a fatty acid synthase (FAS) from Schizochytrium, biologically active fragments and homologues thereof, a nucleic acid sequence encoding such FAS, fragments and homologues thereof, the gene encoding Schizochytrium FAS, host cells and organisms that recombinantly express the FAS, host cells and organisms in which the expression and/or activity of the endogenous FAS has been attenuated, and various methods for making and using any of these proteins, nucleic acid molecules, genes, host cells or organisms.
    Type: Application
    Filed: May 1, 2009
    Publication date: September 10, 2009
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James G. Metz, Craig A. Weaver, Jerry Kuner
  • Carotene synthase gene and uses therefor
    Patent number: 7585659
    Abstract: Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: September 8, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, James G. Metz, Jerry M. Kuner, Frank H. Overton, Jr.
  • Carotene synthase gene and uses therefor
    Patent number: 7582451
    Abstract: Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: September 1, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, James G. Metz, Jerry M. Kuner, Frank H. Overton, Jr.