Patents Assigned to Martek Biosciences
  • Method for production of arachidonic acid
    Patent number: 7666657
    Abstract: The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: February 23, 2010
    Assignee: Martek Biosciences, Inc.
    Inventor: William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7662597
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: February 16, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • Solventless extraction process
    Patent number: 7662598
    Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: February 16, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: Craig M. Ruecker, Swithwin Patrick Adu-peasah, Brian S. Engelhardt, George T. Veeder, III
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20100024050
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 28, 2010
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7645597
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: January 12, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7645598
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: January 12, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7642074
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: January 5, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7638315
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: December 29, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • OXYLIPINS FROM STEARIDONIC ACID AND GAMMA-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20090320148
    Abstract: Disclosed are novel oxylipins that are derived from ?-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
    Type: Application
    Filed: January 31, 2007
    Publication date: December 24, 2009
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Linda Mary Aaterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Dutt Vinjamoori
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7629450
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: December 8, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7626009
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: December 1, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611874
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611876
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7611875
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608702
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608753
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Craig A. Weaver, William R. Barclay, James H. Flatt
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7608703
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: October 27, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7605245
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: October 20, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • PUFA polyketide synthase systems and uses thereof
    Patent number: 7601522
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: October 13, 2009
    Assignee: Martek Biosciences Corporation
    Inventors: Craig A. Weaver, Ross Zirkle, James G. Metz
  • Method for production of arachidonic acid
    Patent number: 7601523
    Abstract: The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: October 13, 2009
    Assignee: Martek Biosciences Corporation
    Inventor: William R. Barclay