Patents Assigned to Maruishi Pharmaceutical Co., Ltd.
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Publication number: 20220202781Abstract: Provided is a dexmedetomidine-containing non-aqueous external preparation being capable of suppressing the precipitation of a crystal of dexmedetomidine in the preparation, and having satisfactory transdermal absorbability. The non-aqueous external preparation includes: (A) dexmedetomidine or a salt thereof; (B) an aliphatic alcohol having 10 to 12 carbon atoms; (C) a propylene glycol monoester of a fatty acid having 6 to 16 carbon atoms; (D) an organic acid; and (E) an organic acid salt.Type: ApplicationFiled: May 26, 2020Publication date: June 30, 2022Applicants: KYUKYU PHARMACEUTICAL CO., LTD., MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Ryo UCHITOMI, Yuhiro YAMAZAKI
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Patent number: 10869876Abstract: The present invention provides a rocuronium preparation with an excellent stability. The rocuronium preparation contains rocuronium and a buffer solution and having an adjusted pH of 3.5 or less (for example, 2.5 to 3.5). The buffer solution may be a citric acid-sodium hydroxide buffer solution, a tartaric acid-sodium hydroxide buffer solution, a potassium hydrogen phthalate-hydrochloric acid buffer solution, a glycine-hydrochloric acid buffer solution, or the like. Such a rocuronium preparation has, for example, after 6-month storage at 40° C., a generation rate of rocuronium-related substance C of 5% or less.Type: GrantFiled: June 26, 2014Date of Patent: December 22, 2020Assignee: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Yutaka Itsuji, Hironori Nagahara, Keisuke Jinbo
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Patent number: 10821119Abstract: Provided is a rocuronium preparation designed to reduce vascular pain to be induced. The rocuronium preparation contains rocuronium and a buffer solution, and has titratable acidity of 100 mEg or less. The buffer solution may be an acetate buffer solution, a citrate buffer solution, a formate buffer solution, a tartrate buffer solution, a phosphate buffer solution, a glycine-hydrochloric acid buffer solution, or a citric acid-phosphate buffer solution.Type: GrantFiled: June 23, 2014Date of Patent: November 3, 2020Assignee: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Keisuke Jinbo, Yutaka Itsuji
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Patent number: 10035767Abstract: Provided are a method for industrially advantageously producing a highly purified pentapeptide and an intermediate thereof. A compound represented by the following formula (1) or a salt thereof: wherein R1 represents an alkyl group or an aralkyl group.Type: GrantFiled: December 19, 2014Date of Patent: July 31, 2018Assignee: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Asami Murayama, Takaaki Kano
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Patent number: 9974754Abstract: Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.Type: GrantFiled: December 17, 2014Date of Patent: May 22, 2018Assignees: MARUISHI PHARMACEUTICAL CO., LTD., KYUKYU PHARMACEUTICAL CO., LTD.Inventors: Yuhiro Yamazaki, Nobuhiro Nosaka
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Publication number: 20170183307Abstract: Provided are a method for industrially advantageously producing a highly purified pentapeptide and an intermediate thereof. A compound represented by the following formula (1) or a salt thereof: wherein R1 represents an alkyl group or an aralkyl group.Type: ApplicationFiled: December 19, 2014Publication date: June 29, 2017Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Asami MURAYAMA, Takaaki KANO
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Publication number: 20170128463Abstract: The present invention provides a rocuronium preparation with an excellent stability. The rocuronium preparation contains rocuronium and a buffer solution and having an adjusted pH of 3.5 or less (for example, 2.5 to 3.5). The buffer solution may be a citric acid-sodium hydroxide buffer solution, a tartaric acid-sodium hydroxide buffer solution, a potassium hydrogen phthalate-hydrochloric acid buffer solution, a glycine-hydrochloric acid buffer solution, or the like. Such a rocuronium preparation has, for example, after 6-month storage at 40° C., a generation rate of rocuronium-related substance C of 5% or less.Type: ApplicationFiled: June 26, 2014Publication date: May 11, 2017Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Yutaka ITSUJI, Hironori NAGAHARA, Keisuke JINBO
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Patent number: 9585398Abstract: A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection: (a) 40 to 90% (w/w) of ethanol, isopropyl alcohol or a mixture thereof; (b) 0.1 to 2% (w/w) of lactic acid; (c) 0.01 to 2% (w/w) of citric acid; and (d) 0.001 to 0.1% (w/w) of a zinc-containing compound which releases zinc ion in solution, relative to the whole disinfectant.Type: GrantFiled: February 6, 2015Date of Patent: March 7, 2017Assignee: MARUISHI PHARMACEUTICAL CO., LTDInventors: Kazuki Okamoto, Junji Okunishi, Yutaka Nishihara, Masahiko Seto
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Publication number: 20160310441Abstract: Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.Type: ApplicationFiled: December 17, 2014Publication date: October 27, 2016Applicants: MARUISHI PHARMACEUTICAL CO., LTD., KYUKYU PHARMACEUTICAL CO., LTD.Inventors: Yuhiro YAMAZAKI, Nobuhiro NOSAKA
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Patent number: 9452216Abstract: Provided is an agent for stabilizing acetaminophen in an aqueous composition, the agent comprising glycine. The agent further comprising at least one kind of sulfurous acid salt selected from the group consisting of sodium sulfite, potassium sulfite and potassium pyrosulfite is more effective. The stabilizing includes preventing precipitation.Type: GrantFiled: December 7, 2011Date of Patent: September 27, 2016Assignee: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Yutaka Itsuji, Yuko Itsuji, Mai Nomura, Hironori Nagahara
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Publication number: 20160143919Abstract: Provided is a rocuronium preparation designed to reduce vascular pain to be induced. The rocuronium preparation contains rocuronium and a buffer solution, and has titratable acidity of 100 mEg or less. The buffer solution may be an acetate buffer solution, a citrate buffer solution, a formate buffer solution, a tartrate buffer solution, a phosphate buffer solution, a glycine-hydrochloric acid buffer solution, or a citric acid-phosphate buffer solution.Type: ApplicationFiled: June 23, 2014Publication date: May 26, 2016Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Keisuke JINBO, Yutaka ITSUJI
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Publication number: 20150359465Abstract: The hand hygiene moment measuring system of the present invention includes a subject sensing device (2) to sense a subject's position and posture, a movement sensing device (3) to sense a subject's movement, a storage unit (4) to store particular combinations corresponding to hand hygiene opportunities, and a counter (5) to count a number of times combinations of a sensing information of the subject sensing device, a sensing information of the movement sensing device, and an object position information indicating a position of an object, achieved the combinations stored in the storage unit.Type: ApplicationFiled: January 31, 2014Publication date: December 17, 2015Applicant: Maruishi Pharmaceutical Co., Ltd.Inventor: Yuji Wada
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Publication number: 20150150265Abstract: A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection: (a) 40 to 90% (w/w) of ethanol, isopropyl alcohol or a mixture thereof; (b) 0.1 to 2% (w/w) of lactic acid; (c) 0.01 to 2% (w/w) of citric acid; and (d) 0.001 to 0.1% (w/w) of a zinc-containing compound which releases zinc ion in solution, relative to the whole disinfectant.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Kazuki OKAMOTO, Junji OKUNISHI, Yutaka NISHIHARA, Masahiko SETO
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Publication number: 20150079197Abstract: An object of the present invention is to provide a medicine for general anesthesia which can prevent and/or alleviate an anesthetic-induced neurological deficit in the brain (preferably in the developing brain). The present invention relates to a medicine which comprises a combination of a general anesthetic and hydrogen and can prevent and/or alleviate an anesthetic-induced neurological deficit in the brain (preferably in the developing brain).Type: ApplicationFiled: May 30, 2013Publication date: March 19, 2015Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Tomiei Kazama, Yasushi Satoh, Ryuji Yonamine
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Patent number: 8980313Abstract: A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection: (a) 40 to 90% (w/w) of ethanol, isopropyl alcohol or a mixture thereof; (b) 0.1 to 2% (w/w) of lactic acid; (c) 0.01 to 2% (w/w) of citric acid; and (d) 0.001 to 0.1% (w/w) of a zinc-containing compound which releases zinc ion in solution, relative to the whole disinfectant.Type: GrantFiled: March 4, 2008Date of Patent: March 17, 2015Assignee: Maruishi Pharmaceutical Co., Ltd.Inventors: Kazuki Okamoto, Junji Okunishi, Yutaka Nishihara, Masahiko Seto
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Patent number: 8586067Abstract: A microbicidal and antiseptic composition, which comprises the following (a), (b) and (c): (a) at least one kind of alcohols selected from the group consisting of ethanol and isopropanol; (b) at least one kind of carboxyvinyl polymers selected from the group consisting of polyacrylic acids, polyacrylates, copolymers of polyacrylic acids and polyacrylic acid alkyl esters, and copolymers of polyacrylates and polyacrylic acid alkyl esters; and (c) agar.Type: GrantFiled: November 14, 2007Date of Patent: November 19, 2013Assignee: Maruishi Pharmaceutical Co., Ltd.Inventors: Kazuki Okamoto, Tsuyoshi Miura, Manabu Soga, Yutaka Nishihara
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Publication number: 20100151046Abstract: A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection: (a) 40 to 90% (w/w) of ethanol, isopropyl alcohol or a mixture thereof; (b) 0.1 to 2% (w/w) of lactic acid; (c) 0.01 to 2% (w/w) of citric acid; and (d) 0.001 to 0.1% (w/w) of a zinc-containing compound which releases zinc ion in solution, relative to the whole disinfectant.Type: ApplicationFiled: March 4, 2008Publication date: June 17, 2010Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Kazuki Okamoto, Junji Okunishi, Yutaka Nishihara, Masahiko Seto
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Publication number: 20100028291Abstract: A microbicidal and antiseptic composition, which comprises the following (a), (b) and (c): (a) at least one kind of alcohols selected from the group consisting of ethanol and isopropanol; (b) at least one kind of carboxyvinyl polymers selected from the group consisting of polyacrylic acids, polyacrylates, copolymers of polyacrylic acids and polyacrylic acid alkyl esters, and copolymers of polyacrylates and polyacrylic acid alkyl esters; and (c) agar.Type: ApplicationFiled: November 14, 2007Publication date: February 4, 2010Applicant: MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Kazuki Okamoto, Tsuyoshi Miura, Manabu Soga, Yutaka Nishihara
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Patent number: 7521451Abstract: Provided is a novel isoindoline compound of the formula (I): The compound is useful for anesthesia by inducing sedation in a mammal.Type: GrantFiled: November 25, 2003Date of Patent: April 21, 2009Assignee: Maruishi Pharmaceutical Co., Ltd.Inventors: Kouhei Toyooka, Norimasa Kanamitsu, Masakazu Yoshimura, Haruo Kuriyama, Takashi Tamura
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Publication number: 20090041859Abstract: [Problems] The objective is to provide a new low-toxic drug for external use for intractable diseases, such as erosion, decubitus, and skin ulcer, that prevents cicatrization and reduces iodine accumulation on wound surfaces with sufficiently promoting healing. [Means for solving problem] Preparation of a wound treatment drug for external use containing oily bases and iodine but substantially no white soft sugar, which is a characteristic of the drug of this invention. The invented drug prevents infection through the wound surface due to a sufficient bactericidal effect of iodine, and promotes wound healing, prevents cicatrization and reduces iodine accumulation on the wound surface by maintenance of appropriate moisture in the wound surface due to a moisturizing effect of oily bases.Type: ApplicationFiled: April 7, 2006Publication date: February 12, 2009Applicants: Mie University, MARUISHI PHARMACEUTICAL CO., LTD.Inventors: Hitoshi Mizutani, Yoshiaki Miyamoto, Atsushi Nishikawa