Abstract: Examples of compositions of liposomes and methods of making the same containing high concentrations of contrast-enhancing agents for computed tomography are provided. Example compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes stable, that is, resistant to leakage of the contrast-enhancing agents, including the extrusion of the liposomes at high pressures and at high flow rates per total pore area of the extrusion filters.
Type:
Application
Filed:
March 18, 2010
Publication date:
January 5, 2012
Applicants:
Board of Regents of the University of Texas System, Marval Biosciences, Inc
Inventors:
Ananth Annapragada, Russell M. Lebovitz, Ketankumar B. Ghaghada
Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.
Type:
Grant
Filed:
November 10, 2006
Date of Patent:
August 31, 2010
Assignee:
Marval Biosciences, Inc.
Inventors:
Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi
Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.
Type:
Grant
Filed:
April 21, 2004
Date of Patent:
May 11, 2010
Assignee:
Marval Biosciences, Inc.
Inventors:
Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi
Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.
Type:
Application
Filed:
January 22, 2009
Publication date:
October 22, 2009
Applicant:
Marval BioSciences, Inc.
Inventors:
Efstathios Karathanasis, Russell M. Lebovitz, Ananth Annapragada, Ravi V. Bellamkonda