Patents Assigned to Massachusetts Institiute of Technology
  • Optical and electrical methods and apparatus for molecule detection
    Patent number: 5846708
    Abstract: A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: December 8, 1998
    Assignee: Massachusetts Institiute of Technology
    Inventors: Mark A. Hollis, Daniel J. Ehrlich, R. Allen Murphy, Bernard B. Kosicki, Dennis D. Rathman, Richard H. Mathews, Barry E. Burke, Mitch D. Eggers, Michael E. Hogan, Rajender Singh Varma