Abstract: A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.

Abstract: A time interpolator circuit increases the accuracy of digital counting circuits.

Abstract: A vector RF modulation system includes a sampling receiver that monitors modulator RF output and provides IF signals for a processor that calculates modulator calibration parameters.

Abstract: A time interpolator circuit increases the accuracy of digital counting circuits.

Abstract: The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.

Abstract: The described invention provides compositions and methods for preventing or treating a disease, condition, or pathologic process characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The method includes administering a therapeutic amount of a pharmaceutical composition comprising a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier.

Abstract: A tag detecting system for detecting a movement of a person or an object that mounts an RFID tag, a moving object detecting method, and an entrance/exit management system using the moving object detecting system are provided. The tag detecting system detects a specific person or object by restricting a detection area of the RFID tag to a narrow area. Since the moving object detecting method detects a piggyback, the entrance/exit system prevents the piggyback even if there are a number of persons passing through an entrance/exit gate almost at the same time.

Abstract: A compressed implant composite for repairing mineralized tissue. The compressed implant composite includes a matrix formed of biopolymeric fibers and a plurality of calcium- and/or silicate-based mineral particles dispersed in the matrix. The matrix constitutes 4 to 80% by weight and the mineral particles constitute 20 to 96% by weight of the composite. The composite is free of soluble collagen and is expandable to a volume 2 to 100 times of its compressed volume (e.g., upon absorption of water). Also disclosed are methods of preparing the above-described composite.

Abstract: A system for generating an interactive calendar guide to scheduled web-based events is described. The guide can be presented in any format, including a grid view and a first view, within various media, including at a website hosting the interactive guide and as a widget on a computer display. A user can interact with elements of the guide, select elements of the guide for more information, customize events presented in the guide, filter the results displayed in the guide, send a response to attend an event, go directly to an event from the guide, and modify the presentation format of the guide.

Abstract: A system for generating an interactive calendar guide to scheduled web-based events is described. The guide can be presented in any format, including a grid view and a list view, within various media, including at a website hosting the interactive guide and as a widget on a computer display. A user can interact with elements of the guide, select elements of the guide for more information, customize events presented in the guide, filter the results displayed in the guide, send a response to attend an event, go directly to an event from the guide, and modify the presentation format of the guide.

Abstract: This invention relates to a method for preparing a porous bone implant containing a calcium-based mineral. The method includes immersing a porous matrix in an acidic solution containing a calcium-based mineral; removing the matrix from the solution; and exposing the matrix to an alkali to neutralize the acidic solution, thereby causing precipitation of the calcium-based mineral to obtain a porous bone implant containing a calcium-based mineral.

Abstract: An article (10) such as a grid fin that controls the direction of flight of a vehicle, has precisely formed passages (14) with porous locating walls (52A, 52B) and a layer of fibrous material (86) such as graphite cloth lying against one or both opposite sides of the locating wall, and with the locating wall and fibrous material impregnated with resin (84). Locating blocks (30) of foam are molded and the fibrous material (42) is wrapped around each block. The wrapped blocks (44) are each inserted into a passage (54) of a locating grid (50), so the fibrous material is compressed. The locating grid lies in a grid-holding mold (60). With the fiber-wrapped blocks inserted, the grid-holding mold is closed and resin is injected into the mold and allowed to harden. The foam blocks are removed by eroding them, as by sand blasting them, to leave a final article.

Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

Abstract: The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.

Abstract: A surface-reinforced article includes a core assembly (12) comprising a foam core (20) with a surface region (22) that includes fine inner fibrous material intimately surround by foam that is integral with foam of the core, and an outer reinforcing covering (14) which includes an outer layer (32) of fibrous material and a resin (30) surrounding the outer layer of fibrous material and covering the primarily foam core assembly. The fine inner fibrous material (91-94) includes coupling fibers (100) with inner ends (102) embedded in the foam and outer ends (106) embedded in the resin, to better hold the resin to the foam. The primarily foam core assembly is molded within a first mold cavity (64) formed between spacers (60, 62) that lie within a second mold cavity (50).

Abstract: A low phase noise PLL synthesizer is described in which an initial tuning mechanism uses a conventional divider loop to lock a VCO to a desired output frequency. Once initial lock is achieved, the divider loop is switched out of the circuit in favor of a low phase noise mixer loop. The local oscillator signal for the mixer is derived from the same low phase noise source as the phase comparison frequency.

Abstract: A re-rollable membrane for wrapping around and protecting a cylindrical tissue having an injury site. The membrane includes a sheet of a porous matrix formed of cross-linked biopolymeric fibers. In one implementation, the sheet can be spirally rolled so that at least one portion overlaps another portion of the sheet and, upon absorption of a fluid, the overlapping portions adhere to each other closely so as to exclude penetration of cells. In another implementation, the sheet can be helically rolled to form a helix having a pitch of 2 mm to 40 mm and an inner diameter of 1 mm to 50 mm. Also disclosed are methods for making and using such re-rollable membranes.