Abstract: An anti-microbial/-allergenic sleep set and process of forming thereof is provided and comprises a mattress and box spring, each having an allergen-impermeable barrier layer incorporated within. The mattress comprises a support apparatus, a top and bottom panel, first and second flanges, a border, a foam layer, and a barrier layer. The border is positioned around the support apparatus, and is attached to the top and bottom panels. The foam layer, which can comprise a latex emulsion, is positioned between the support apparatus and the top and bottom panels. The barrier layer comprises a material configured to be impermeable by allergens, and is attached at its outer periphery to the interior facing sides of the top panel, the bottom panel, and the border.