Abstract: The invention relates to antibodies or antibody fragments that bind CD269 (BCMA), thereby disrupting the interaction between CD269 and its native ligands (BAFF and APRIL), and their use in the treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.
Type:
Grant
Filed:
November 1, 2013
Date of Patent:
January 29, 2019
Assignee:
MAX-DELRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Inventors:
Martin Lipp, Felix Oden, Uta Höpken, Gerd Müller, Oliver Daumke, Stephen Marino, Daniel Olal