Abstract: A computer-implemented method for compressing digital data includes obtaining a sequence of digital data values; mapping the sequence of digital data values to a sequence of code words having non-uniform bit lengths; packing the sequence of code words into a sequence of storage words having uniform bit length and corresponding to a fixed-size piece of data handled as a unit by the instruction set or the hardware of a processor; and outputting the sequence of storage words together with a first bitmask indicating the bit length of each code word, wherein in the method is implemented using special purpose vector instructions.
Type:
Application
Filed:
April 14, 2020
Publication date:
May 4, 2023
Applicant:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Abstract: A hollow-core photonic crystal fiber (HC-PCF) (10) for guiding at least one mode of a light field (1) along a mode guiding section (11) of the HC-PCF (10), comprises an outer jacket (12), an inner cladding (13) and a hollow core (14), which extend along the HC-PCF (10), wherein the inner cladding (13) is arranged on an interior surface of the outer jacket (12) and comprises anti-resonant structures (15) surrounding the hollow core (14), and the hollow core (14) has a mode guiding core diameter (d) provided along the mode guiding section of the HC-PCF (10), and wherein at least one fiber end (16) of the HC-PCF (10) has a light field coupling section (17) in which the hollow core (14) is tapered over an axial coupling section length from a fiber end core diameter (D) at the at least one fiber end (16) to the mode guiding core diameter (d). Furthermore, methods of using the HC-PCF and manufacturing the HC-PCF are described.
Type:
Grant
Filed:
May 26, 2021
Date of Patent:
May 2, 2023
Assignee:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Inventors:
Sebastian Thomas Bauerschmidt, Patrick Sebastian Uebel, Philip St. J. Russell
Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.
Type:
Application
Filed:
September 21, 2022
Publication date:
March 23, 2023
Applicants:
TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Inventors:
Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
Abstract: The present invention relates to a method for producing a panel of cells (i.e. a cell library) expressing various different mutant variants of a protein of interest, wherein only one of said mutant variants is expressed per cell from a single gene copy. The present invention also relates to a method or cell library for identifying a mutant variant of a protein of interest having a different or modified biological activity as compared to the corresponding wild-type protein of interest. According to the present invention the identified mutant variant of a protein of interest may be applied for white biotechnology.
Type:
Grant
Filed:
July 31, 2017
Date of Patent:
March 21, 2023
Assignee:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
Inventors:
David Ng, Oliver Griesbeck, Mutlu Erdogan
Abstract: The invention relates to a workstation (1), a preparation station (2) and a method for manipulating an electron microscopy grid assembly (3). The workstation (1) comprises a first compartment (101), a first gas inlet (102) for generating an overpressure in the first compartment (101), a first glove (104) and a second glove (105), each being fixed in a respective opening (106, 107) of the workstation (1), wherein the first glove (104) and the second glove (105) are movable in the first compartment (101) to manipulate objects in the first compartment (101), wherein the workstation (1) comprises a port (109) for providing a transfer device (4) for an electron microscopy grid assembly (3) in the first compartment (101).
Type:
Application
Filed:
February 4, 2021
Publication date:
March 9, 2023
Applicant:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.
Abstract: The present invention relates to compounds represented by general formula (Ia), (Ib), (IIa) or (IIb). These compounds are suitable for imaging alpha-synuclein and for diagnosing diseases which are associated with the aggregation of alpha-synuclein. The compounds are also useful for treating and preventing diseases which are associated with the aggregation of alpha-synuclein.
Type:
Application
Filed:
November 19, 2020
Publication date:
March 2, 2023
Applicants:
MODAG GMBH, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Inventors:
Armin GIESE, Felix SCHMIDT, Daniel WECKBECKER, Andrei LEONOV, Sergey RYAZANOV, Christian GRIESINGER, Bernd PICHLER, Kristina HERFERT, Andreas MAURER, Laura KÜBLER, Sabrina BUSS
Abstract: A quantum device includes a non-reciprocal transmission structure, wherein the transmission structure is designed such that for first waves traversing the transmission structure in a forward direction the phases of the first waves are at least partially conserved, and for second waves traversing the transmission structure in a backward direction, the phases of the second waves are at least partially replaced by random ones, such that the phase conservation is more pronounced in the forward direction than in the backward direction.
Type:
Grant
Filed:
April 5, 2019
Date of Patent:
February 28, 2023
Assignee:
Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
Abstract: The present invention relates to a marker that can be used as aging biomarker. More specifically, the present invention relates to the analysis of nucleolar size as a biomarker for aging and metabolic health and its relation to the virtual age, or the life expectancy of animals, including humans. The aging biomarker of the invention can be used to study the effect of medication, food compounds and/or special diets on the wellness and virtual age, or the life expectancy of animals, including humans.
Type:
Grant
Filed:
March 2, 2018
Date of Patent:
February 7, 2023
Assignee:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
Inventors:
Adam Antebi, Varnesh Tiku, Pieternella Slagboom
Abstract: A quantum device comprising a transmission structure, wherein based on quantum collapse, interference and selective absorption the transmission structure is designed such that quantum waves emitted by at least two bodies, for example, by thermal excitation, are passed preferentially to a subset of these bodies.
Type:
Grant
Filed:
September 12, 2019
Date of Patent:
January 31, 2023
Assignee:
Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
Abstract: An optical component comprising a planar metasurface arranged on a surface of a first substrate and a top layer arranged in a height direction Z above the metasurface, wherein the metasurface comprises a plurality of scattering structures, wherein a dielectric material is deposited on a subset of the plurality of scattering structures, wherein an active media is sandwiched between the metasurface and the top layer, wherein an incident electromagnetic radiation is transmitted or reflected by the optical component, wherein a phase profile modulation is induced on the incident electromagnetic radiation during the reflection or transmission.
Type:
Application
Filed:
November 13, 2020
Publication date:
January 26, 2023
Applicant:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.
Type:
Grant
Filed:
February 18, 2019
Date of Patent:
January 24, 2023
Assignees:
Baycrest Centre for Geriatric Care, Codebox Computerdienste GmbH, Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften e.V., Universite D'Aix Marseille
Inventors:
Anthony Randal McIntosh, Jochen Mersmann, Viktor Jirsa, Petra Ritter
Abstract: The present invention relates to rhodamine-type fluorophores being present in two states, a cell-permeable non-florescent form and a fluorescent form. The present invention also relates to use of the fluorophores in staining and live cell fluorescence imaging. The compounds have general formula (10) or the general formula (10?).
Type:
Application
Filed:
December 6, 2019
Publication date:
December 22, 2022
Applicant:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.
Abstract: An apparatus and a corresponding method for generating at least one random number are disclosed. The apparatus includes an optical parametric oscillator being pumped by a pump signal with a predetermined pump power and a predetermined pump frequency. The optical parametric oscillator is configured to operate in a period multiplication state for providing an oscillator output signal of alternating light pulses, the oscillator output signal having a period that is N-times the period of the pump signal, where N is an integer and N>I. The apparatus also includes a comparing unit being configured to compare the output signal with a reference signal, wherein the reference signal has a frequency that is 1/N of the predetermined pump frequency, and an evaluation unit being configured to generate the at least one random number based on the comparison of the output signal with the reference signal.
Type:
Grant
Filed:
October 30, 2017
Date of Patent:
December 13, 2022
Assignees:
UNIVERSITAT STUTTGART, MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
Inventors:
Tobias Steinle, Ilja Gerhardt, Johannes Nikolaus Greiner, Harald Giessen
Abstract: A circuit for delaying an electric signal (CI), comprises an input for the electric signal (CI); an input for a control signal (EI); a first storage element (U5) for storing the control signal; a delay element for delaying the electric signal; and an output for the delayed electric signal (CO). According to the invention, the electric signal is delayed, based on the stored control signal. The delay circuit is employed in a fast all-digital clock frequency adaptation circuit for voltage droop tolerance.
Type:
Grant
Filed:
March 11, 2019
Date of Patent:
December 6, 2022
Assignee:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
Inventors:
Christoph Lenzen, Matthias Függer, Ben Wiederhake, Attila Kinali, Mordechai Medina
Abstract: The present invention relates to a gripping apparatus comprising a membrane; a flexible housing; with said membrane being fixedly connected to a periphery of the housing. The invention further relates to a method of producing a gripping apparatus.
Type:
Grant
Filed:
May 2, 2018
Date of Patent:
November 29, 2022
Assignees:
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V., CARNEGIE MELLON UNIVERSITY
Abstract: A method where a propeller is set into locomotion relative to a medium at least partially surrounding the propeller. An actuator induces a rotation of the propeller relative to the medium and about a rotational axis of the propeller, and the propeller converts its rotational movement into locomotion relative to the medium. The aspect ratio of at least one cross-section of the propeller is three or more. Also a helical or modifiedly helical propeller for converting rotational movement of the propeller into locomotion of the propeller relative to a medium at least partially surrounding the propeller, where the aspect ratio of at least one cross section of the propeller is three or more. And a method of producing a propeller, including the step of providing a plate extending along the helical axis, where the aspect ratio of at least one cross section of the plate is three or more.
Type:
Grant
Filed:
April 11, 2018
Date of Patent:
November 8, 2022
Assignee:
Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
Abstract: The present invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) nitrate as a metal cation ligand and (ii) a metal cation chelating domain comprising a chelating ligand and a label and/or carrier. This complex can be used for attaching a label and/or a carrier to a target molecule, preferably a protein. The attachment of the label or carrier via the complex of the invention involves the replacement of the metal cation ligand with a coordinating group of the target molecule so that a product complex with the target molecule as primary ligand in the coordination sphere of the metal cation is formed. Accordingly, the present invention also provides for uses and methods involving the attachment of a label and/or carrier to a target molecule.
Type:
Application
Filed:
June 18, 2020
Publication date:
October 13, 2022
Applicants:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Universität Heidelberg
Inventors:
Amelie S. BENK, Lucia T. BENK, Seraphine WEGNER, Peter COMBA, Joachim P. SPATZ
Abstract: The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.
Type:
Application
Filed:
August 5, 2020
Publication date:
October 6, 2022
Applicants:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Heinrich-Heine-Universität Düsseldorf
Inventors:
Lennart Schada Von Borzyskowski, Tobias Jürgen Erb, Andreas Paul Michael Weber, Marc-Sven Roll
Abstract: The present invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) a metal cation ligand being a carbonate selected from CO32? and HCO3— and (ii) a metal cation chelating domain comprising a chelating ligand and a label and/or carrier. This complex can be used for attaching a label and/or a carrier to a target molecule, preferably a protein. The attachment of the label or carrier via the complex of the invention involves the replacement of the metal cation ligand with a coordinating group of the target molecule so that a product complex with the target molecule as primary ligand in the coordination sphere of the metal cation is formed. Accordingly, the present invention also provides for uses and methods involving the attachment of a label and/or carrier to a target molecule.
Type:
Application
Filed:
June 18, 2020
Publication date:
September 29, 2022
Applicants:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Universität Heidelberg
Inventors:
Amelie S. BENK, Franziska SCHENK, Seraphine WEGNER, Peter COMBA, Joachim P. SPATZ
Abstract: The present invention relates in a first aspect to a plug flow tubular bioreactor having an integral or multi-part tube adapted for cultivation, and, optionally, infection, viral transduction, or transfection of eukaryotic cells. In a further aspect, the present invention relates to a plug flow tubular bioreactor system comprising the plug flow tubular bioreactor according to the present invention. Further, the present invention relates to a method for preparing virus particles, vectors, cells or other molecules including toxic molecules using the plug flow tubular bioreactor or the system according to the present invention. Finally, the present invention relates to the use of a plug flow tubular bioreactor for the preparation of virus particles, vectors including viral vectors, cells including modified cells or other molecules including toxic molecules.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
September 13, 2022
Assignee:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Inventors:
Felipe Tapia, Yvonne Genzel, Udo Reichl