Abstract: The present invention relates to a method of fabricating a shape-changeable magnetic member comprising a plurality of segments with each segment being able to be magnetized with a desired magnitude and orientation of magnetization, to a method of producing a shape changeable magnetic member composed of a plurality of segments and to a shape changeable magnetic member.

Abstract: A broadband light source device (100) for creating broadband light pulses (1) comprises a hollow-core fiber (10) of non-bandgap type including a filling gas and being arranged for creating the broadband light pulses (1) by an optical nonlinear broadening of pump laser pulses (2), wherein the hollow-core fiber (10) has an axial hollow light guiding fiber core (11), which supports core modes of a guided light field, and an inner fiber structure (12), which surrounds the fiber core (11) and which supports transverse wall modes of the guided light field, and a pump laser source device (20) being arranged for creating and providing the pump laser pulses (2) at an input side (13) of the hollow-core fiber (10), wherein the transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes, the broadband light pulses (1) have a core mode spectrum being determined by a fiber length, a fiber core diameter, at least one pump pulse and/or beam parameter of the pump laser pu

Abstract: The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

Abstract: Thin films, which are deposited on a sacrificial film on a substrate, are released and bonded back on a substrate surface. This technology provides open and closed 2D confined micro-/nano-channels and channel networks on a substrate surface. The geometry, size and complexity of the channels and channel networks can be modified by the film and substrate properties as well as the treatment techniques of the sacrificial layer etching. A method to fabricate such structures with position- and pattern-controllability is provided.

Abstract: The present invention relates to a method for identifying and producing effectors of peptidyl-prolyl cis/trans isomerases which can be activated by calmodulin. The invention also relates to the use of the identified effectors for the production of medicaments and to screening methods and kits.

Abstract: The present invention relates to bioelectronic devices comprising lipid vesicles which are in contact with a chip, particularly with at least one gate of a field effect transistor. The vesicles/bilayers may comprise effector molecules in their membrane and thus are suitable as bioelectronic sensors. The chip may also have a capacitive stimulating spot, with which the electrical or functional state of the membrane or its incorporated molecules may be affected.

Abstract: The present invention relates to a novel method for testing the developmel status in pancreatic cells of a mammal. The present invention further relates to applications in the medical field that directly arise from the method of the invention. Additionally, the present invention relates to transgenic mammals comprising at least one inactivated Pax6 allele and optionally at least one inactivated Pax4 allele.