Patents Assigned to Maxygen, Inc.
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20070020734
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: September 13, 2006
    Publication date: January 25, 2007
    Applicants: MAXYGEN, INC., ROCHE PALO ALTO LLC
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Variant subtilising enzymes (subtilases)
    Publication number: 20070015677
    Abstract: Novel subtilases having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
    Type: Application
    Filed: May 6, 2004
    Publication date: January 18, 2007
    Applicants: Novozymes A/S, Maxygen Inc.
    Inventors: Stefan Minning, Jurgen Carsten Franz Knotzel, Niels Sorensen, Jon Ness, Mark Welch, Lorraine Giver, Joel Cherry, Torben Borchert, Jeremy Minshull
  • Methods and compositions for polypeptide engineering
    Publication number: 20070009930
    Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
    Type: Application
    Filed: April 14, 2006
    Publication date: January 11, 2007
    Applicant: Maxygen, Inc.
    Inventors: Phillip Patten, Willem Stemmer
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 7148054
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: December 12, 2006
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda A. Castle, Claus M. Krebber, Steve Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Novel co-stimulatory molecules
    Publication number: 20060269566
    Abstract: The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
    Type: Application
    Filed: January 13, 2006
    Publication date: November 30, 2006
    Applicant: Maxygen, Inc.
    Inventors: Juha Punnonen, Alexandra Lazetic, Steven Leong, Chia-Chun Chang, Doris Apt, Claes Gustafsson
  • Cytokine polypeptides and nucleic acids
    Publication number: 20060264615
    Abstract: New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic acids, methods of making the polypeptides and nucleic acid, antibodies to the polypeptides, and methods of using the polypeptides and nucleic acids are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are also provided.
    Type: Application
    Filed: April 5, 2006
    Publication date: November 23, 2006
    Applicant: Maxygen, Inc.
    Inventors: Steven Leong, Juha Punnonen
  • Methods and compositions for cellular and metabolic engineering
    Publication number: 20060257890
    Abstract: The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selection to “evolve” individual genes, whole plasmids or viruses, multigene clusters, or even whole genomes. Such techniques do not require the extensive analysis and computation required by conventional methods for metabolic engineering.
    Type: Application
    Filed: February 7, 2006
    Publication date: November 16, 2006
    Applicant: Maxygen, Inc.
    Inventors: Jeremy Minshull, Willem Stemmer
  • Methods and compositions for polypeptide engineering
    Publication number: 20060223143
    Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
    Type: Application
    Filed: November 23, 2005
    Publication date: October 5, 2006
    Applicant: Maxygen, Inc.
    Inventors: Phillip Patten, Willem Stemmer
  • Cytokine polypeptides
    Patent number: 7115712
    Abstract: New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic acids, methods of making the polypeptides and nucleic acid, antibodies to the polypeptides, and methods of using the polypeptides and nucleic acids are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are also provided.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 3, 2006
    Assignee: Maxygen, Inc.
    Inventors: Steven R. Leong, Juha Punnonen
  • Methods and compositions for cellular and metabolic engineering
    Patent number: 7105297
    Abstract: The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selection to “evolve” individual genes, whole plasmids or viruses, multigene clusters, or even whole genomes. Such techniques do not require the extensive analysis and computation required by conventional methods for metabolic engineering.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: September 12, 2006
    Assignee: Maxygen, Inc.
    Inventors: Jeremy Minshull, Willem P. C. Stemmer
  • Co-stimulatory polypeptides
    Patent number: 7094875
    Abstract: The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: August 22, 2006
    Assignee: Maxygen, Inc.
    Inventors: Juha Punnonen, Alexandra L. L. Lazetic, Steven R. Leong, Chia-Chun Chang
  • Chimeric promoters
    Patent number: 7074590
    Abstract: This invention provides novel chimeric promoter/enhancers. The chimeric promoter/enhancers are particularly suitable for directing gene expression in mammalian cells.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: July 11, 2006
    Assignee: Maxygen, Inc.
    Inventors: Juha Punnonen, Anne Wright, Andrey Semyonov
  • Methods for making character strings, polynucleotides and polypeptides having desired characteristics
    Publication number: 20060142950
    Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Application
    Filed: January 24, 2006
    Publication date: June 29, 2006
    Applicant: Maxygen, Inc
    Inventors: Sergey Selifonov, Willem Stemmer, Claes Gustafsson, Matthew Tobin, Stephen del Cardayre, Phillip Patten, Jeremy Minshull, Lorraine Giver
  • Methods for making character strings, polynucleotides and polypeptides having desired characteristics
    Patent number: 7058515
    Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: June 6, 2006
    Assignee: Maxygen, Inc.
    Inventors: Sergey A. Selifonov, Willem P. C. Stemmer, Claes Gustafsson, Matthew Tobin, Stephen del Cardayre, Phillip A. Patten, Jeremy Minshull, Lorraine J. Giver
  • Modified ribulose 1,5-bisphosphate carboxylase/oxygenase for improvement and optimization of plant phenotypes
    Publication number: 20060117409
    Abstract: The invention relates to methods and compositions for generating, modifying, adapting, and optimizing polynucleotide sequences that encode proteins having Rubisco biosynthetic enzyme activities which are useful for introduction into plant species, agronomically-important microorganisms, and other hosts, and related aspects.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 1, 2006
    Applicant: Maxygen, Inc.
    Inventors: Willem Stemmer, Venkitswaran Subramanian, Genhai Zhu, Lu Liu, Sergey Selifonov
  • Methods for making character strings, polynucleotides and polypeptides having desired characteristics
    Patent number: 7024312
    Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: April 4, 2006
    Assignee: Maxygen, Inc.
    Inventors: Sergey A. Selifonov, Willem P. C. Stemmer, Claes Gustafsson, Matthew Tobin, Stephen del Cardayre, Phillip A. Patten, Jeremy Minshull, Lorraine J. Giver
  • Oligonucleotide mediated nucleic acid recombination
    Publication number: 20060051795
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: August 15, 2005
    Publication date: March 9, 2006
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem Stemmer, Jeremy Minshull, Steven Bass, Mark Welch, Jon Ness, Claes Gustafsson, Phillip Patten
  • Methods of populating data structures for use in evolutionary simulations
    Publication number: 20060047611
    Abstract: In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.
    Type: Application
    Filed: August 22, 2005
    Publication date: March 2, 2006
    Applicant: Maxygen, Inc.
    Inventors: Sergey Selifonov, Willem Stemmer
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Patent number: 6995017
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: February 7, 2006
    Assignee: Maxygen, Inc.
    Inventor: Willem P. C. Stemmer
  • Combinatorial libraries of monomer domains
    Publication number: 20050221384
    Abstract: Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
    Type: Application
    Filed: October 15, 2004
    Publication date: October 6, 2005
    Applicants: Avidia Research Institute, Maxygen, Inc.
    Inventors: Joost Kolkman, Willem Stemmer, Per-Ola Freskgard