Patents Assigned to McNeil Laboratories, Incorporated
  • Uncatalyzed aroylation of 1-alkylpyrrole-2-acetic acid derivatives
    Patent number: 3998844
    Abstract: A process of aroylating 1-alkylpyrrole-2-acetic acid esters and nitriles without employing the usual Friedel-Crafts of catalyst.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: December 27, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: John Robert Carson
  • Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants
    Patent number: 3998958
    Abstract: Compounds of the class of 1-aryl-3-pyrrolidylidene ureas, 1-aryl-3-piperidylidene ureas and 1-aryl-3-hexahydroazepinylidene ureas, useful as central nervous system (CNS) depressants.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: December 21, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventors: Chris Royce Rasmussen, Joseph Francis Gardocki, James Nelson Plampin
  • 2-(R'-oxymethyl)-perimidines
    Patent number: 3985880
    Abstract: Certain perimidines are observed to be useful antiulcer agents in view of their activity as inhibitors of gastric acid secretion and ulcer formation. Among such antiulcer agents are novel 2-(R'-oxymethyl)-perimidine derivatives, wherein R.sup.1 is a member selected from the group consisting of benzoyl, carbamyl, N-loweralkylcarbamyl, and N,N-diloweralkylcarbamyl.
    Type: Grant
    Filed: February 7, 1975
    Date of Patent: October 12, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventors: Vasken Paragamian, Russell J. Taylor, Jr.
  • 4-Oxo-2-imidazolidinylidene ureas
    Patent number: 3983135
    Abstract: Compounds of the class of 4-oxo-2-imidazolidinylidene ureas and 4-oxo-2-hexahydropyrimidinylidene ureas, useful as anti-secretory agents and central nervous system (CNS) depressants.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: September 28, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Chris Royce Rasmussen
  • Inhibition of gastric acid secretion with phenyl-substituted perimidines
    Patent number: 3980782
    Abstract: The use of 2-aryl-perimidines as an inhibitor of gastric acid secretion.
    Type: Grant
    Filed: March 5, 1975
    Date of Patent: September 14, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventors: Vasken Paragamian, Russell J. Taylor, Jr.
  • Inhibition of ulcers with 2(3H)-perimidylidene-2-propanone
    Patent number: 3966935
    Abstract: The use of 2(3H)-perimidylidene-2-propanone as an anti-ulcer agent.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: June 29, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventors: Vasken Paragamian, Russell J. Taylor, Jr.
  • Preparation of pyrrole-2-acetic acid derivatives
    Patent number: 3957818
    Abstract: Catalytic dehydrogenation of .DELTA.-2,.alpha.-pyrrolidenemalonates and .DELTA.-2,.alpha.-pyrrolidenemalononitriles yields pyrrole-2-acetates and pyrrole-2-acetonitriles, respectively. Subsequent hydrolysis of the latter affords pyrrole-2-acetic acids.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: May 18, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: John Robert Carson
  • Inhibition of ulcers with pyrrolyl-substituted perimidines
    Patent number: 3957993
    Abstract: The use of 2-pyrrolyl-perimidines as antiulcer agents.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: May 18, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Russell J. Taylor, Jr.
  • Inhibition of gastric acid secretion with substituted perimidines
    Patent number: 3957991
    Abstract: The use of 2-(1-perimidine)ethanol and 2-(1-perimidine)-acetonitrile as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: May 18, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Russell J. Taylor, Jr.
  • Inhibition of gastric acid secretion with 2-pyridyl-perimidine
    Patent number: 3957992
    Abstract: The use of pyridyl-substituted perimidines as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: May 18, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Russell J. Taylor, Jr.
  • Inhibition of gastric acid secretion with 2-(tetrahydrofuryl)perimidine
    Patent number: 3956496
    Abstract: The use of 2-(tetrahydrofuryl)perimidine as an inhibitor of gastric acid secretion.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: May 11, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Russell J. Taylor, Jr.
  • Inhibition of gastric acid secretion with 1-dialkylamidomethyl-2-alkyl perimidines
    Patent number: 3956497
    Abstract: The use of 1-dialkylamidomethyl-2-alkyl-perimidines as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 7, 1975
    Date of Patent: May 11, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Russell J. Taylor, Jr.
  • Aroyl-substituted pyrroles
    Patent number: 3952012
    Abstract: The compounds are of the class of 5-aroyl-pyrrole alkanoic acids and corresponding acid derivatives thereof useful as anti-inflammatory agents and as synthetic intermediates.
    Type: Grant
    Filed: June 17, 1974
    Date of Patent: April 20, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: John Robert Carson
  • 2-Aryl-4-(R-methyl)-5-methylimidazoles
    Patent number: 3932445
    Abstract: 2-Aryl-5-methylimidazoles bearing various substituted methyls in the 4-position useful for their ultra-violet (U.V.) absorbing properties.
    Type: Grant
    Filed: June 26, 1974
    Date of Patent: January 13, 1976
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Chris Royce Rasmussen