Patents Assigned to ME Medical Enzymes AG
  • Method for producing therapeutically suitable glutaminase
    Patent number: 7052689
    Abstract: DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anticancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: May 30, 2006
    Assignees: ME Medical Enzymes AG
    Inventors: Joseph Roberts, Thomas W MacAllister, Natarajan Sethuraman, Abbie G. Freeman
  • Genetically engineered glutaminase and its use in antiviral and anticancer therapy
    Patent number: 6312939
    Abstract: DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: November 6, 2001
    Assignee: ME Medical Enzymes AG
    Inventors: Joseph Roberts, Thomas W MacAllister, Natarajan Sethuraman, Abbie G. Freeman